Leptomeningeal Disease

• CLINICAL_TRIALS research · 2026-04-14
  Clinical Trial Update: Optimizing Contrast Dose and Scanning Parameters for Detection of Leptomeningeal Disease [NA]

  This clinical trial update describes a study at MD Anderson Cancer Center aimed at optimizing contrast dose and MRI scanning parameters to i…

• CLINICAL_TRIALS research · 2026-04-08
  Clinical Trial Update: Non Interventional German Leptomeningeal Disease Register

  A non-interventional register in Germany is recruiting to collect data on meningeal neoplasms and leptomeningeal disease (NCT06146010).

• CLINICAL_TRIALS trial_result · 2026-03-02
  Clinical Trial Update: Avelumab With Radiotherapy in Patients With Leptomeningeal Disease [Phase 1]

  A Phase 1 trial evaluating the combination of avelumab with radiotherapy in patients with leptomeningeal disease/metastases has completed.

• CLINICAL_TRIALS research · 2026-02-09
  Clinical Trial Update: Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease [Phase 1, Phase 2]

  This is an early-phase trial evaluating radiation therapy followed by intrathecal trastuzumab and pertuzumab for HER2-positive breast cancer…

• CLINICAL_TRIALS trial_result · 2026-02-05
  Clinical Trial Update: B7-H3.CD28Z.CART in CNS Neoplasms [Phase 1]

  A Phase 1 clinical trial evaluating B7-H3.CD28Z.CART for central nervous system neoplasms is currently not yet recruiting.

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• CLINICAL_TRIALS research · 2025-12-23
  Clinical Trial Update: Study Assessing QBS72S For Treating Brain Metastases [Phase 2]

  Stanford University is conducting a Phase 2 trial of QBS72S for brain metastases. The study lists brain metastases, breast cancer, lung canc…

• CLINICAL_TRIALS research · 2025-12-22
  Clinical Trial Update: A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer [Phase 1]

  A Phase 1 study is evaluating the safety and tolerability of AZD1390 in combination with radiation therapy for brain cancer, including prima…

• CLINICAL_TRIALS research · 2025-11-18
  Clinical Trial Update: Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal Disease [Phase 2]

  Phase 2 clinical trial evaluating capecitabine, tucatinib, and intrathecal trastuzumab for leptomeningeal metastasis/disease in HER2-positiv…

• CLINICAL_TRIALS trial_result · 2021-01-26
  Clinical Trial Update: Pembrolizumab in Patients With Leptomeningeal Disease [Phase 2]

  Phase 2 trial update for pembrolizumab in patients with leptomeningeal disease has been terminated; results posted.