Leiomyosarcoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2023-12-06Clinical Trial Update: ATX-101 in Advanced Dedifferentiated Liposarcoma and Leiomyosarcoma [Phase 2]
Phase 2 clinical trial update for ATX-101 in advanced dedifferentiated liposarcoma and leiomyosarcoma has been terminated with results poste…
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CLINICAL_TRIALS trial_result · 2023-11-07Clinical Trial Update: Doxorubicin With Upfront Dexrazoxane for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma [Phase 2]
Phase 2 trial evaluating doxorubicin with upfront dexrazoxane for advanced or metastatic soft tissue sarcoma has completed enrollment with r…
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CLINICAL_TRIALS trial_result · 2023-11-02Clinical Trial Update: A Study of OR2805, a Monoclonal Antibody Targeting CD163, Alone and in Combination With Anticancer Agents [Phase 1, Phase 2]
Phase 1/2 trial evaluating OR2805, a anti-CD163 monoclonal antibody, alone and with anticancer agents for solid tumors, with unspecified sta…
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CLINICAL_TRIALS trial_result · 2023-10-10Clinical Trial Update: Treatment of Metastatic Soft Tissue Sarcoma (STS) Patients (FIBROSARC USA) [Phase 2]
Phase 2 trial update for treatment of metastatic soft tissue sarcoma (leiomyosarcoma) under FIBROSARC USA.
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CLINICAL_TRIALS trial_result · 2023-07-07Clinical Trial Update: M6620 (VX-970) in Selected Solid Tumors [Phase 2]
Phase 2 trial of M6620 (VX-970) in selected solid tumors completed; results posted in 2023.
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CLINICAL_TRIALS trial_result · 2022-04-29Clinical Trial Update: Avelumab and Trabectedin in Treating Patients With Liposarcoma or Leiomyosarcoma That is Metastatic or Cannot Be Removed by Surgery [Phase 1, Phase 2]
Clinical trial evaluating avelumab plus trabectedin in metastatic or unresectable liposarcoma and leiomyosarcoma; the study has terminated w…
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CLINICAL_TRIALS trial_result · 2021-11-01Clinical Trial Update: Efficacy Study on Trabectedin in Retroperitoneal Leiomyosarcoma and Well Differentiated/Dedifferentiated Liposarcoma [Phase 2]
Phase 2 trial update on trabectedin for liposarcoma and leiomyosarcoma completed.
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CLINICAL_TRIALS trial_result · 2021-08-31Clinical Trial Update: A Study of LY3435151 in Participants With Solid Tumors [Phase 1]
Phase 1 study of LY3435151 in solid tumors, including triple-negative breast cancer, terminated with results posted.
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CLINICAL_TRIALS trial_result · 2021-02-04Clinical Trial Update: Avelumab in Combination With Gemcitabine in Advanced Leiomyosarcoma as a Second-line Treatment [Phase 2]
Phase 2 trial update evaluating avelumab in combination with gemcitabine for advanced, metastatic leiomyosarcoma as second-line therapy.
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CLINICAL_TRIALS trial_result · 2020-07-27Clinical Trial Update: Vorinostat (SAHA) in Uterine Sarcoma [Phase 2]
Phase 2 clinical trial testing vorinostat (SAHA) in uterine sarcoma was terminated; results posted in 2020.
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EMA label_change · 2020-07-24Authorised uses of cancer medicine Yondelis unchanged following review of new data
The EMA review concluded that the authorised uses of Yondelis (trabectedin) remain unchanged after evaluating new data.
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CLINICAL_TRIALS trial_result · 2020-05-12Clinical Trial Update: Nivolumab Alone or in Combination With Ipilimumab in Treating Patients With Advanced Uterine Leiomyosarcoma [Phase 2]
Phase 2 clinical trial evaluating nivolumab alone or in combination with ipilimumab in patients with advanced or unresectable uterine leiomy…
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CLINICAL_TRIALS trial_result · 2020-01-31Clinical Trial Update: Efficacy of Gemcitabine With Pazopanib as Second Line Treatment in Patient With Metastatic or Relapsed Uterine [Phase 2]
Phase 2 trial evaluating gemcitabine with pazopanib as second-line therapy in metastatic or relapsed uterine leiomyosarcoma.
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CLINICAL_TRIALS withdrawal · 2019-05-13Clinical Trial Update: Study on Leiomyosarcoma, Liposarcomas and Synovial Sarcoma With Trabectedin [Phase 3]
A Phase 3 trial studying trabectedin for leiomyosarcoma, liposarcoma, and synovial sarcoma was withdrawn.
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CLINICAL_TRIALS trial_result · 2019-01-29Clinical Trial Update: SARC018: A Study of Mocetinostat and Gemcitabine in Patients With Metastatic Leiomyosarcoma [Phase 2]
Phase 2 study SARC018 evaluated mocetinostat in combination with gemcitabine for metastatic leiomyosarcoma; results were posted in 2019.
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CLINICAL_TRIALS trial_result · 2018-07-17Clinical Trial Update: A Five-Tier, Open-Label Study of IMC-A12 in Advanced Sarcoma [Phase 2]
Open-label Phase 2 study of IMC-A12 (cixutumumab) in advanced sarcomas. Results were posted in 2018.
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CLINICAL_TRIALS trial_result · 2018-07-11Clinical Trial Update: A Study of Trabectedin (YONDELIS) in Patients With Locally Advanced or Metastatic Liposarcoma or Leiomyosarcoma [Phase 3]
This clinical trial update notes the completion of a Phase 3 study evaluating trabectedin (YONDELIS) in patients with locally advanced or me…
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CLINICAL_TRIALS research · 2018-07-02Clinical Trial Update: Detection of Circulating Tumor Cells in Patients With Sarcomas
An update on a clinical trial investigating detection of circulating tumor cells in patients with sarcomas, including Leiomyosarcoma, Pleomo…
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FDA approval · 2018-06-29FDA Approved: YONDELIS — Supplemental Application (Janssen Products, LP)
FDA approved a supplemental application for YONDELIS (trabectedin) from Janssen Products, LP.
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CLINICAL_TRIALS trial_result · 2017-05-19Clinical Trial Update: Bevacizumab and Radiation Therapy for Sarcomas [Phase 2]
Phase 2 trial evaluating bevacizumab with radiation therapy in soft tissue sarcomas completed, with results posted in 2017.
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CLINICAL_TRIALS trial_result · 2017-05-12Clinical Trial Update: Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma [Phase 2]
Phase 2 clinical trial update for romidepsin (depsipeptide) in patients with metastatic or unresectable soft tissue sarcoma, with results po…
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CLINICAL_TRIALS trial_result · 2017-01-26Clinical Trial Update: Study of Doxorubicin and Trabectedin in First Line Treatment on Patients With Metastatic Leiomyosarcoma [Phase 2]
Phase 2 trial evaluating first-line Doxorubicin and Trabectedin in metastatic leiomyosarcoma has completed; results are not detailed in this…
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CLINICAL_TRIALS trial_result · 2016-12-28Clinical Trial Update: Alisertib in Treating Patients With Advanced or Metastatic Sarcoma [Phase 2]
A Phase 2 trial update of alisertib in patients with advanced or metastatic soft tissue sarcomas, including myxofibrosarcoma and several his…
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CLINICAL_TRIALS trial_result · 2016-05-17Clinical Trial Update: Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma [Phase 1]
This Phase 1 trial evaluated the combination of cixutumumab and doxorubicin in patients with unresectable, locally advanced, or metastatic s…
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CLINICAL_TRIALS research · 2016-05-17Clinical Trial Update: Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas
A completed clinical trial update studying gene expression in tissue samples from children and adolescents with soft tissue sarcomas to bett…