Leber Hereditary Optic Neuropathy
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CLINICAL_TRIALS trial_result · 2020-01-28Clinical Trial Update: Efficacy Study of GS010 for the Treatment of Vision Loss up to 6 Months From Onset in LHON Due to the ND4 Mutation [Phase 3]
GenSight Biologics completed a Phase 3 efficacy study of GS010 for vision loss due to Leber hereditary optic neuropathy (ND4 mutation). Resu…
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CLINICAL_TRIALS trial_result · 2020-01-23Clinical Trial Update: Efficacy Study of GS010 for Treatment of Vision Loss From 7 Months to 1 Year From Onset in LHON Due to the ND4 Mutation (REVERSE) [Phase 3]
This entry covers the Phase 3 REVERSE trial of GS010 for vision loss in Leber hereditary optic neuropathy due to the ND4 mutation. Results w…
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CLINICAL_TRIALS trial_result · 2016-05-02Clinical Trial Update: Safety and Efficacy Study of rAAV2-ND4 Treatment of Leber Hereditary Optic Neuropathy (LHON) [NA]
Clinical trial update reporting safety and efficacy results for rAAV2-ND4 in Leber Hereditary Optic Neuropathy; study completed with results…
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CLINICAL_TRIALS withdrawal · 2014-11-25Clinical Trial Update: Emergency Administration of EPI-743 to a Single Patient With Leber's Hereditary Optic Neuropathy [LHON]
This update notes emergency administration of EPI-743 to a single patient with Leber's hereditary optic neuropathy, and indicates the trial …
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CLINICAL_TRIALS trial_result · 2014-09-29Clinical Trial Update: Near-infrared Light-emitting Diode (NIR-LED) Therapy for Leber's Hereditary Optic Neuropathy (LHON) [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluated near-infrared LED therapy for Leber's Hereditary Optic Neuropathy; the study was terminated with result…
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CLINICAL_TRIALS withdrawal · 2014-08-22Clinical Trial Update: Study With Idebenone in Patients With Chronic Vision Loss Due to Leber's Hereditary Optic Neuropathy (LHON) [Phase 3]
A Phase 3 trial of idebenone for chronic vision loss due to Leber's hereditary optic neuropathy has been withdrawn.
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CLINICAL_TRIALS research · 2014-06-27Clinical Trial Update: Trial of Cyclosporine in the Acute Phase of Leber Hereditary Optic Neuropathy [Phase 2]
A Phase 2 clinical trial update evaluating cyclosporine in the acute phase of Leber hereditary optic neuropathy.
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CLINICAL_TRIALS trial_result · 2014-05-15Clinical Trial Update: Leber Hereditary Optic Neuropathy (LHON) Historical Case Record Survey
This clinical trial update notes the completion of a historical case record survey for Leber Hereditary Optic Neuropathy (LHON) sponsored by…
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CLINICAL_TRIALS trial_result · 2013-05-27Clinical Trial Update: Study to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic Neuropathy [Phase 2]
A Phase 2 clinical trial evaluating idebenone for efficacy, safety, and tolerability in Leber's Hereditary Optic Neuropathy has completed.
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CLINICAL_TRIALS trial_result · 2013-05-27Clinical Trial Update: RHODOS Follow-up Single-visit Study
The RHODOS follow-up single-visit trial in Leber's hereditary optic neuropathy has completed, according to an update from Santhera.
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CLINICAL_TRIALS trial_result · 2012-12-24Clinical Trial Update: A Randomized, Double-blind, Placebo-controlled Trial of Curcumin in Leber's Hereditary Optic Neuropathy (LHON) [Phase 3]
Phase 3 randomized, double-blind, placebo-controlled trial of curcumin for Leber hereditary optic neuropathy has been completed.