Laryngeal Squamous Cell Carcinoma

• CLINICAL_TRIALS trial_result · 2025-06-27
  Clinical Trial Update: Testing the Addition of M6620 (VX-970, Berzosertib) to Usual Chemotherapy and Radiation for Head and Neck Cancer [Phase 1]

  Phase 1 trial evaluating the addition of M6620 (berzosertib; VX-970) to standard chemotherapy and radiation for head and neck cancers, inclu…

• CLINICAL_TRIALS research · 2025-06-06
  Clinical Trial Update: Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and Neck [Phase 2]

  This is a Phase 2 clinical trial update examining nivolumab in combination with BMS986205 for stage II-IV squamous cell cancers of the head …

• CLINICAL_TRIALS trial_result · 2025-06-04
  Clinical Trial Update: A Phase II Trial of PG2 in Patients With Advanced Pharyngeal or Laryngeal Squamous Cell Carcinoma Under Concurrent Chemoradiotherapy [Phase 2]

  This Phase II trial of PG2 in patients with advanced pharyngeal or laryngeal squamous cell carcinoma undergoing concurrent chemoradiotherapy…

• CLINICAL_TRIALS withdrawal · 2025-04-04
  Clinical Trial Update: Vorinostat in Combination With Chemoradiation in Locally Advanced HPV Negative HNSCC [Phase 2]

  Phase 2 trial of vorinostat with chemoradiation for locally advanced head and neck squamous cell carcinoma has been withdrawn.

• CLINICAL_TRIALS trial_result · 2025-03-17
  Clinical Trial Update: Tolinapant and Radiation for Cisplatin-Ineligible, Previously Untreated, Locally Advanced Head and Neck Cancer [EARLY_Phase 1]

  Early-phase trial evaluating Tolinapant in combination with radiation for cisplatin-ineligible, previously untreated locally advanced head a…

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• CLINICAL_TRIALS withdrawal · 2025-02-14
  Clinical Trial Update: NT-I7 for the Treatment of Recurrent Squamous Cell Carcinoma of Head and Neck Undergoing Surgery [Phase 1]

  A Phase 1 trial of NT-I7 for recurrent squamous cell carcinoma of the head and neck undergoing surgery was terminated.

• CLINICAL_TRIALS research · 2025-02-13
  Clinical Trial Update: Study of a Pembrolizumab-based Organ Preservation Strategy for Locally Advanced Larynx Cancers [Phase 2]

  This Phase 2 clinical trial, sponsored by the Latin American Cooperative Oncology Group, is evaluating a pembrolizumab-based organ preservat…

• CLINICAL_TRIALS trial_result · 2025-02-11
  Clinical Trial Update: Onalespib in Treating Patients With Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck Receiving Radiation Therapy and Cisplatin [Phase 1]

  Phase 1 trial evaluating the safety and tolerability of Onalespib in combination with radiation therapy and cisplatin for locoregionally adv…

• CLINICAL_TRIALS research · 2025-02-03
  Clinical Trial Update: Decisional Regret in Open Partial Horizontal Laryngectomy

  This document reports a recruiting clinical trial evaluating decisional regret after open partial horizontal laryngectomy in patients with l…

• CLINICAL_TRIALS trial_result · 2025-01-27
  Clinical Trial Update: A Phase II Study to Evaluate the Efficacy and Safety of Salvage Preoperative PD-1 Inhibitor Combined with Chemotherapy Neoadjuvant Therapy in Recurrent and Metastatic LPSCC/HPSCC [Phase 2]

  A Phase II clinical trial is evaluating salvage preoperative PD-1 inhibitor in combination with chemotherapy as neoadjuvant therapy for recu…

• CLINICAL_TRIALS trial_result · 2024-12-27
  Clinical Trial Update: Pembrolizumab & Cabozantinib in Patients With Head and Neck Squamous Cell Cancer [Phase 2]

  Phase 2 trial evaluating the combination of pembrolizumab and cabozantinib in head and neck squamous cell carcinoma reported results, with r…

• CLINICAL_TRIALS trial_result · 2024-10-29
  Clinical Trial Update: Image-guided Proton Therapy for the Treatment of Locally Advanced Unresectable Head and Neck Cancer [Phase 1]

  This Phase 1 trial update reports the completion of a study evaluating image-guided proton therapy for locally advanced unresectable head an…

• CLINICAL_TRIALS trial_result · 2024-07-31
  Clinical Trial Update: Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Carboplatin Followed By Chemoradiation in Treating Patients With Recurrent Head and Neck Cancer [Phase 1]

  Phase 1 trial of nab-paclitaxel (albumin-bound paclitaxel) with carboplatin followed by chemoradiation in patients with recurrent head and n…

• CLINICAL_TRIALS withdrawal · 2024-07-25
  Clinical Trial Update: Testing the Addition of an Investigational Drug, Xevinapant, to Usual Radiation Therapy Plus Cisplatin/Carboplatin for Patients With Head and Neck Cancer [Phase 2]

  Phase 2 trial evaluating Xevinapant added to standard radiation therapy plus cisplatin/carboplatin for head and neck cancers has been withdr…

• CLINICAL_TRIALS trial_result · 2024-04-01
  Clinical Trial Update: Nivolumab, Carboplatin, and Paclitaxel in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery [Phase 2]

  A phase 2 trial evaluated the combination of nivolumab with carboplatin and paclitaxel in patients with stage III-IV head and neck squamous …

• CLINICAL_TRIALS trial_result · 2022-12-14
  Clinical Trial Update: Comparison of Adaptive Dose Painting by Numbers With Standard Radiotherapy for Head and Neck Cancer. [Phase 2]

  Phase 2 clinical trial comparing adaptive dose painting by numbers with standard radiotherapy for head and neck cancer has completed.

• CLINICAL_TRIALS trial_result · 2022-01-25
  Clinical Trial Update: Combination Chemotherapy With or Without Erlotinib Hydrochloride in Treating Patients With Metastatic or Recurrent Squamous Cell Carcinoma of the Head and Neck [Phase 2]

  This Phase 2 trial evaluated chemotherapy with or without erlotinib in patients with metastatic or recurrent head and neck squamous cell car…

• CLINICAL_TRIALS trial_result · 2021-03-12
  Clinical Trial Update: A Study of Chemoradiation Plus Pembrolizumab for Locally Advanced Laryngeal Squamous Cell Carcinoma [Phase 1, Phase 2]

  Phase 1/2 study evaluating chemoradiation plus pembrolizumab for locally advanced laryngeal squamous cell carcinoma has completed with resul…

• CLINICAL_TRIALS trial_result · 2020-05-01
  Clinical Trial Update: Parenteral Nutrition for Patients Treated for Locally Advanced Inoperable Tumors of the Head and Neck [Phase 3]

  Phase 3 clinical trial investigating parenteral nutrition for patients treated for locally advanced inoperable head and neck squamous cell c…

• CLINICAL_TRIALS trial_result · 2019-11-15
  Clinical Trial Update: Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma [Phase 3]

  Phase 3 study evaluating chemotherapy with or without bevacizumab for recurrent or metastatic head and neck squamous cell carcinoma; results…

• CLINICAL_TRIALS trial_result · 2018-11-16
  Clinical Trial Update: Stereotactic Body Radiation Therapy in Treating Patients With High Risk Locally Advanced Head and Neck Cancer [NA]

  A terminated clinical trial evaluating stereotactic body radiation therapy for high-risk locally advanced head and neck cancers; results wer…

• CLINICAL_TRIALS trial_result · 2017-04-14
  Clinical Trial Update: Capecitabine and Vorinostat in Treating Patients With Recurrent and/or Metastatic Head and Neck Cancer [Phase 2]

  A Phase 2 trial evaluating the combination of capecitabine and vorinostat for recurrent/metastatic head and neck squamous cell carcinomas wa…

• CLINICAL_TRIALS trial_result · 2016-10-24
  Clinical Trial Update: Soy Isoflavones in Preventing Head and Neck Cancer Recurrence in Patients With Stage I-IV Head and Neck Cancer Undergoing Surgery [Phase 2]

  Phase 2 clinical trial evaluating whether soy isoflavones can prevent recurrence of head and neck squamous cell carcinomas after surgery; re…

• CLINICAL_TRIALS trial_result · 2016-07-26
  Clinical Trial Update: Ganetespib Window of Opportunity Study in Head and Neck Cancers [Phase 1]

  A Phase 1 window-of-opportunity study of ganetespib in head and neck squamous cell carcinomas has been terminated, involving hypopharyngeal,…

• CLINICAL_TRIALS trial_result · 2015-12-04
  Clinical Trial Update: Observational Study of Swallowing Function After Treatment of Advanced Laryngeal Cancer

  This trial update reports the completion of an observational study assessing swallowing function after treatment for advanced laryngeal canc…