Juvenile Myelomonocytic Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy [Phase 1]
This clinical trial aims to determine the highest tolerated dose of imetelstat when given with fludarabine and cytarabine in children with r…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia [Phase 1, Phase 2]
A Phase I/II clinical trial evaluating the combination of trametinib and azacitidine for newly diagnosed juvenile myelomonocytic leukemia (J…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study [Phase 1, Phase 2]
PedAL BCU, LLC is conducting a pediatric screening trial to test bone marrow and blood methods in children with relapsed or hard-to-treat ac…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies [Phase 2]
Phase 2 clinical trial evaluating MT2021-08T, a T-cell receptor alpha/beta-depleted donor peripheral blood stem cell product, for hematologi…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation [Phase 1]
Phase 1 trial evaluating CIML NK cell infusion for relapse of myeloid disease after hematopoietic cell transplantation; the study is current…
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CLINICAL_TRIALS trial_result · 2026-03-04Clinical Trial Update: TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies [Phase 2]
Phase 2 clinical trial update evaluating TCRαβ-depleted progenitor cell graft with added memory T-cell donor lymphocyte infusion and selecti…
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT [NA]
Clinical trial update indicates ongoing recruitment for a study evaluating CD45RA-depleted peripheral stem cell addback to prevent viral or …
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant [Phase 1]
This clinical trial update describes a Phase 1 study evaluating HA-1 TCR T-cell immunotherapy for relapsed or refractory acute leukemia afte…
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CLINICAL_TRIALS research · 2025-08-12Clinical Trial Update: Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation [Phase 2]
This clinical trial update describes a Phase 2 study evaluating TCRγδ T cells and memory T cells with selective use of blinatumomab as part …
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CLINICAL_TRIALS research · 2025-08-11Clinical Trial Update: Vorinostat Dose-escalation After Allogeneic Hematopoietic Cell Transplantation [Phase 1]
A Phase 1 dose-escalation study of vorinostat after allogeneic hematopoietic cell transplantation is ongoing.
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CLINICAL_TRIALS trial_result · 2025-06-15Clinical Trial Update: Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant Diseases [Phase 2]
A Phase 2 clinical trial is testing alpha/beta T cell and CD19+ B cell depletion in allogeneic stem cell transplantation for malignant disea…
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CLINICAL_TRIALS research · 2024-08-27Clinical Trial Update: Myeloproliferative Neoplasms (MPNs) Patient Registry
An update on the Myeloproliferative Neoplasms (MPNs) Patient Registry sponsored by University Health Network in Toronto, currently recruitin…
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CLINICAL_TRIALS trial_result · 2024-07-16Clinical Trial Update: Trametinib in Treating Patients With Relapsed or Refractory Juvenile Myelomonocytic Leukemia [Phase 2]
A Phase 2 clinical trial update on trametinib for relapsed or refractory Juvenile Myelomonocytic Leukemia (JMML), including patients with Ne…
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CLINICAL_TRIALS research · 2024-06-04Clinical Trial Update: CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant [Phase 1, Phase 2]
This clinical trial update examines using CD34+ malignant stem cell selection for patients receiving allogeneic stem cell transplants in Pha…
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CLINICAL_TRIALS trial_result · 2023-11-07Clinical Trial Update: Stem Cell Transplant for Juvenile Myelomonocytic Leukemia (JMML) [Phase 1, Phase 2]
A completed Phase 1/2 clinical trial evaluating stem cell transplantation for Juvenile Myelomonocytic Leukemia (JMML) conducted by Masonic C…
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CLINICAL_TRIALS trial_result · 2023-09-28Clinical Trial Update: Preventing of GVHD With Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and Calcineurin Inhibitor at Patients With Hemoblastosis [Phase 3]
Phase 3 clinical trial evaluating a post-transplant immunomodulatory regimen (cyclophosphamide, abatacept, vedolizumab, and a calcineurin in…
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CLINICAL_TRIALS trial_result · 2021-02-02Clinical Trial Update: Sorafenib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Leukemia [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating sorafenib in pediatric patients with relapsed or refractory solid tumors or leukemia; results completed …
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CLINICAL_TRIALS trial_result · 2020-10-12Clinical Trial Update: Donor Lymphocyte Infusion With Azacitidine to Prevent Hematologic Malignancy Relapse After Stem Cell Transplantation [Phase 2]
Phase 2 clinical trial evaluating donor lymphocyte infusion with azacitidine to prevent relapse after stem cell transplantation.
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CLINICAL_TRIALS trial_result · 2020-05-04Clinical Trial Update: Treosulfan-based Conditioning in Paediatric Patients With Haematological Malignancies [Phase 2]
Phase 2 trial update evaluating treosulfan-based conditioning in pediatric patients with hematological malignancies.
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CLINICAL_TRIALS trial_result · 2019-07-11Clinical Trial Update: Study With Azacitidine in Pediatric Subjects With Newly Diagnosed Advanced Myelodysplastic Syndrome (MDS) and Juvenile Myelomonocytic Leukemia (JMML) [Phase 2]
A Phase 2 clinical trial evaluating azacitidine in pediatric patients with newly diagnosed advanced myelodysplastic syndrome and juvenile my…
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CLINICAL_TRIALS trial_result · 2018-12-05Clinical Trial Update: Busulfan, Cyclophosphamide, and Melphalan or Busulfan and Fludarabine Phosphate Before Donor Hematopoietic Cell Transplant in Treating Younger Patients With Juvenile Myelomonocytic Leukemia [Phase 2]
Phase 2 trial evaluating conditioning regimens with busulfan-based chemotherapy before donor hematopoietic cell transplant in younger patien…
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CLINICAL_TRIALS trial_result · 2018-07-19Clinical Trial Update: Collecting and Storing Malignant, Borderline Malignant Neoplasms, and Related Samples From Young Patients With Cancer
This Clinical Trial Update describes a study collecting and storing malignant and related samples from young cancer patients; the trial stat…
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CLINICAL_TRIALS trial_result · 2017-05-09Clinical Trial Update: Donor Bone Marrow Transplant With or Without G-CSF in Treating Young Patients With Hematologic Cancer or Other Diseases [Phase 3]
Phase 3 trial evaluating donor bone marrow transplant with or without G-CSF in young patients with hematologic cancers or related diseases; …
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CLINICAL_TRIALS withdrawal · 2017-05-08Clinical Trial Update: Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk Myelofibrosis or Myeloproliferative Neoplasm (MPN)/Myelodysplastic Syndrome (MDS) [Phase 1]
A Phase 1 trial evaluating pacritinib in combination with low-dose decitabine for intermediate-high risk myelofibrosis and related myeloprol…
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CLINICAL_TRIALS trial_result · 2017-02-20Clinical Trial Update: T-Cell Replete Haploidentical Donor Hematopoietic Stem Cell Plus Natural Killer (NK) Cell Transplantation in Patients With Hematologic Malignancies Relapsed or Refractory Despite Previous Allogeneic Transplant [Phase 2]
Phase 2 trial of T-cell replete haploidentical donor hematopoietic stem cell transplantation with natural killer (NK) cell support in hemato…