Ischemia-reperfusion Injury
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Safety and Efficacy of Treprostinil (Remodulin®) In Reducing Ischemia-Reperfusion Injury During Kidney Transplantation [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating the safety and potential efficacy of treprostinil (Remodulin) to reduce ischemia-reperfusion injury…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Intravenous Estrogen in Kidney Transplant Study [Phase 1, Phase 2]
This document provides an update on a Phase 1/2 clinical trial evaluating intravenous estrogen to mitigate ischemia-reperfusion injury in ki…
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CLINICAL_TRIALS trial_result · 2026-03-25Clinical Trial Update: Non-invasive Remote Ischemic PreConditioning (RIPC) in Free Flaps for Breast Reconstruction [NA]
Completed clinical trial evaluating non-invasive remote ischemic preconditioning to protect free flap breast reconstruction from ischemia-re…
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CLINICAL_TRIALS trial_result · 2026-03-17Clinical Trial Update: Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion [EARLY_Phase 1]
An early-phase clinical trial is evaluating the effect of Vitamin B6 (pyridoxine) on the exercise pressor reflex during leg ischemia–reperfu…
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CLINICAL_TRIALS trial_result · 2026-02-06Clinical Trial Update: Investigation of the Protective Effect of Alpha Lipoic Acid on Ischemic Reperfusion Damage in Ischemic Priapism in Rats [NA]
Preclinical study in rats examining whether alpha-lipoic acid can protect against ischemia-reperfusion damage in priapism.
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CLINICAL_TRIALS research · 2025-09-10Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of BX-001N in Preventing Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) and Major Adverse Kidney Events (MAKE) [Phase 2]
A Phase 2 clinical trial evaluating BX-001N for preventing cardiac surgery-associated acute kidney injury and major adverse kidney events is…
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CLINICAL_TRIALS research · 2025-06-26Clinical Trial Update: Effect of L-Carnitine on Biomarkers of Myocardial Reperfusion Injury in Patients With STEMI [Phase 2]
Phase 2 clinical trial evaluating whether L-Carnitine affects biomarkers of myocardial reperfusion injury in patients with ST-elevation myoc…
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CLINICAL_TRIALS research · 2025-06-18Clinical Trial Update: Auricular Vagus Stimulation and STEMI [NA]
A clinical trial evaluating auricular vagus nerve stimulation for patients with STEMI/acute coronary syndrome is currently recruiting at the…
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CLINICAL_TRIALS research · 2025-05-15Clinical Trial Update: Differential Impact of Pringle and Portal Vein Occlusion on Myocardial Injury After Non-Cardiac Surgeries.
A clinical trial evaluating how Pringle vs. portal vein occlusion affects myocardial injury risk during non-cardiac surgery; currently recru…
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CLINICAL_TRIALS research · 2025-05-15Clinical Trial Update: OSA as a Remote Ischemic Preconditioning in Vascular Surgery
A ClinicalTrials.gov update reports a study evaluating obstructive sleep apnea as a remote ischemic preconditioning approach in vascular sur…
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CLINICAL_TRIALS trial_result · 2025-04-24Clinical Trial Update: The Effect of Prolonged ischemıa and anesthetıc Agents on Oxidative Stress
Duzce University conducted a clinical trial to assess the effect of prolonged ischemia and anesthetic agents on oxidative stress, and the st…
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CLINICAL_TRIALS trial_result · 2025-04-17Clinical Trial Update: A Study to Evaluate the Safety and Pharmacokinetics of BX-001N in Healthy Participants [Phase 1]
Phase 1 trial update showing completion of a safety and pharmacokinetics study of BX-001N in healthy participants, with the ischemia-reperfu…
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CLINICAL_TRIALS research · 2025-04-17Clinical Trial Update: Calcineurin Inhibitor in NEuRoloGically Deceased Donors to Decrease Kidney delaYed Graft Function (CINERGY) [Phase 2]
Phase 2 CINERGY trial evaluating whether administering a calcineurin inhibitor to neurologically deceased donors can reduce delayed graft fu…
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CLINICAL_TRIALS other · 2025-04-03Clinical Trial Update: A Trial to Assess Efficacy and Safety of ex Vivo Allograft Admin of iCM012 Solution 2 mg/ml to Improve Its Function in Recipients of DCD Kidneys [Phase 2, Phase 3]
Clinical trial update for ex vivo administration of iCM012 to improve kidney graft function in donation-after-circulatory-death recipients. …
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CLINICAL_TRIALS trial_result · 2025-03-12Clinical Trial Update: NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial [Phase 2]
Phase 2 clinical trial evaluating NAD+ augmentation for ischemia-reperfusion injury with associated myocardial and kidney injuries is curren…
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CLINICAL_TRIALS trial_result · 2025-02-21Clinical Trial Update: Hypertonic Lactate After Cardiac Arrest [Phase 2]
A Phase 2 clinical trial evaluating hypertonic lactate after cardiac arrest is currently recruiting to assess its effects on ischemia-reperf…
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CLINICAL_TRIALS trial_result · 2024-12-11Clinical Trial Update: Repertaxin in Prevention of Primary Graft Dysfunction After Lung Transplantation [Phase 2]
Phase 2 trial evaluating Repertaxin to prevent primary graft dysfunction after lung transplantation has completed and results posted.
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CLINICAL_TRIALS trial_result · 2024-08-14Clinical Trial Update: Intracoronary Administration of Glucocorticoids as a Treatment Method for No-Glucocorticoid Treatment for No-Reflow in STEMI [Phase 2]
Phase 2 trial evaluating intracoronary glucocorticoids for no-reflow in STEMI has completed.
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CLINICAL_TRIALS trial_result · 2024-08-13Clinical Trial Update: Effects of Anesthesia Technique on Endothelial Function [NA]
A clinical trial is investigating how anesthesia technique affects endothelial function in conditions such as endothelial dysfunction and is…
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CLINICAL_TRIALS other · 2024-07-26Clinical Trial Update: Protecting Autologous Free Flaps From Ischemia/Reperfusion Damage With Cold Storage. [NA]
Clinical trial update from the University of Cagliari describes evaluating cold storage to protect autologous free flap tissue from ischemia…
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CLINICAL_TRIALS research · 2024-07-12Clinical Trial Update: Safety and Efficacy of Remote Ischemic Conditioning for Patients Taking Off-pump Coronary Artery Bypass Grafting [NA]
A clinical trial is investigating remote ischemic conditioning for patients undergoing off-pump coronary artery bypass grafting. The study i…
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CLINICAL_TRIALS trial_result · 2024-06-04Clinical Trial Update: FIH Phase I/IIa Trial Evaluating Safety of TUM012 to Minimize Ischemic Reperfusion Injury in Kidney Transplantation [Phase 1, Phase 2]
An early-phase (Phase I/IIa) clinical trial evaluating the safety of TUM012 to minimize ischemia-reperfusion injury in kidney transplantatio…
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CLINICAL_TRIALS research · 2024-05-23Clinical Trial Update: Intermittent Versus Continuous Surface O2 During HMP of DCD Kidneys [Phase 3]
This update describes a Phase 3 trial comparing intermittent versus continuous surface oxygen during hypothermic machine perfusion of donati…
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CLINICAL_TRIALS trial_result · 2024-03-21Clinical Trial Update: Effect of Dexmedetomidine Preconditioning on Myocardial Ischemia-reperfusion Injury in Patients Undergoing Open Heart Surgery With Cardiopulmonary Bypass [Phase 4]
Phase 4 clinical trial evaluating dexmedetomidine preconditioning for protection against myocardial ischemia-reperfusion injury in open hear…
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CLINICAL_TRIALS trial_result · 2022-11-25Clinical Trial Update: Effectiveness of IV Vitamin C in Reducing Oxidative Stress Associated With Free Flap Surgery [Phase 3]
Phase 3 trial evaluating the effectiveness of intravenous vitamin C to reduce oxidative stress associated with free flap surgery; status cur…