Idiopathic Hypersomnia

• CLINICAL_TRIALS trial_result · 2026-08-27
  Clinical Trial Results: A Study to Investigate the Effect of XYWAV on Sleepiness, Polysomnography, and Functional Outcomes in Participants With Idiopathic Hypersomnia or Narcolepsy [Phase 4]

  Phase 4 trial investigating the effect of XYWAV on sleepiness, polysomnography, and functional outcomes in idiopathic hypersomnia and narcol…

• CLINICAL_TRIALS trial_result · 2026-08-07
  Clinical Trial Results: Clarithromycin Mechanisms in Hypersomnia Syndromes [Phase 2]

  Phase 2 trial results on clarithromycin mechanisms in hypersomnia syndromes including narcolepsy without cataplexy and idiopathic hypersomni…

• CLINICAL_TRIALS trial_result · 2026-06-30
  Clinical Trial Results: Study of SDX in Patients With Idiopathic Hypersomnia (IH) [Phase 2]

  Phase 2 trial results for SDX in idiopathic hypersomnia have been completed with results posted.

• CLINICAL_TRIALS research · 2026-04-16
  Clinical Trial Update: A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia [Phase 2]

  A Phase 2 long-term extension study of ORX750 for Narcolepsy Type 1, Narcolepsy Type 2, and Idiopathic Hypersomnia is currently recruiting.

• CLINICAL_TRIALS research · 2026-03-30
  Clinical Trial Update: A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Idiopathic Hypersomnia (IH) [Phase 3]

  A Phase 3 clinical trial evaluating the efficacy and safety of HBS-301 for idiopathic hypersomnia is currently recruiting.

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• CLINICAL_TRIALS research · 2026-03-24
  Clinical Trial Update: A Study of TAK-360 in Adults With Idiopathic Hypersomnia [Phase 2]

  A Phase 2 clinical trial evaluating TAK-360 in adults with idiopathic hypersomnia, currently recruiting.

• CLINICAL_TRIALS trial_result · 2026-03-18
  Clinical Trial Update: Improving Social Relationships for Adolescents With Central Disorders of Hypersomnolence [NA]

  This document reports the completion of a clinical trial evaluating interventions to improve social relationships for adolescents with centr…

• CLINICAL_TRIALS research · 2026-03-04
  Clinical Trial Update: A Long-Term Study of ALKS 2680 in Subjects With Narcolepsy and Idiopathic Hypersomnia [Phase 2, Phase 3]

  Clinical trial update indicating ongoing long-term Phase 2/Phase 3 studies of ALKS 2680 for narcolepsy types 1 and 2 and idiopathic hypersom…

• CLINICAL_TRIALS trial_result · 2026-02-13
  Clinical Trial Update: Safety and Efficacy of FT218 in Idiopathic Hypersomnia (REVITALYZ) [Phase 3]

  Phase 3 clinical trial update evaluating the safety and efficacy of FT218 for idiopathic hypersomnia, sponsored by Avadel under the REVITALY…

• CLINICAL_TRIALS research · 2026-02-12
  Clinical Trial Update: A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Idiopathic Hypersomnia [Phase 2]

  Phase 2 clinical trial update for ALKS 2680 in idiopathic hypersomnia, currently recruiting to assess safety and effectiveness.

• CLINICAL_TRIALS trial_result · 2025-12-12
  Clinical Trial Update: A Long-Term Safety and Effectiveness Study to Evaluate Pitolisant in Adult Patients With Idiopathic Hypersomnia [Phase 3]

  A completed Phase 3 long-term study assessing the safety and effectiveness of pitolisant in adult patients with idiopathic hypersomnia, incl…

• CLINICAL_TRIALS research · 2025-10-29
  Clinical Trial Update: A Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia [Phase 2]

  This document provides a status update on a Phase 2 clinical trial evaluating ORX750 for narcolepsy type 1, narcolepsy type 2, and idiopathi…

• CLINICAL_TRIALS research · 2025-08-27
  Clinical Trial Update: A Novel Approach to Manage Symptoms of Narcolepsy and Idiopathic Hypersomnia [NA]

  A University of Sydney-sponsored clinical trial is investigating a novel approach to managing symptoms of idiopathic hypersomnia and narcole…

• CLINICAL_TRIALS research · 2025-08-08
  Clinical Trial Update: a Chronobiological Treatment Combining Evening Melatonin and Morning Light Therapy in Idiopathic Hypersomnia: a Prospective, Double Bind, Randomized, Placebo-controlled -Trial [Phase 2]

  A Phase 2 randomized, double-blind trial evaluating evening melatonin in combination with morning light therapy for Idiopathic Hypersomnia i…

• CLINICAL_TRIALS research · 2025-07-25
  Clinical Trial Update: Effect of Low Sodium Oxybate (LXB) on Autonomic Symptom Burden in Idiopathic Hypersomnia Patients With Postural Tachycardia Syndrome [Phase 4]

  This Phase 4 trial from Stanford investigates whether Low Sodium Oxybate (LXB) reduces autonomic symptoms in patients with idiopathic hypers…

• CLINICAL_TRIALS trial_result · 2025-07-17
  Clinical Trial Update: A Study to Investigate the Effect of XYWAV on Sleepiness, Polysomnography, and Functional Outcomes in Participants With Idiopathic Hypersomnia or Narcolepsy [Phase 4]

  A Phase 4 study evaluating XYWAV for sleepiness, polysomnography metrics, and functional outcomes in idiopathic hypersomnia and narcolepsy h…

• CLINICAL_TRIALS trial_result · 2025-07-16
  Clinical Trial Update: Clarithromycin Mechanisms in Hypersomnia Syndromes [Phase 2]

  Phase 2 clinical trial examining clarithromycin mechanisms in hypersomnia syndromes has completed. The study enrolled individuals with narco…

• CLINICAL_TRIALS research · 2025-07-14
  Clinical Trial Update: Low Sodium Oxybate in Patients With Idiopathic Hypersomnia [Phase 4]

  A Phase 4 clinical trial testing low-sodium oxybate in adults with idiopathic hypersomnia is currently recruiting.

• CLINICAL_TRIALS research · 2025-06-29
  Clinical Trial Update: Cardiovascular and Cognitive Implications of Central Disorders of Hypersomnolence and Their Treatments

  A Mayo Clinic-sponsored clinical trial is examining cardiovascular and cognitive effects of central disorders of hypersomnolence (narcolepsy…

• CLINICAL_TRIALS trial_result · 2025-02-03
  Clinical Trial Update: Placebo-Controlled, Double-Blind, Study to Determine the Safety and Efficacy of SDX in Patients With IH [Phase 2]

  A Phase 2, placebo-controlled, double-blind trial evaluating the safety and efficacy of SDX in idiopathic hypersomnia has completed.

• CLINICAL_TRIALS research · 2025-01-13
  Clinical Trial Update: Mind-wandering and Predictive Processes in Narcolepsy: a Putative Mechanism Through Covert REM Intrusions [NA]

  A clinical trial update shows a study exploring mind-wandering and predictive processes in narcolepsy, investigating covert REM intrusions. …

• CLINICAL_TRIALS research · 2024-11-12
  Clinical Trial Update: Deciphering the Interactions Between Food Intake, Sleepiness, and Nighttime Sleep Quality in Patients With Type 1 Narcolepsy and Idiopathic Hypersomnia [NA]

  ClinicalTrials.gov update for NCT06484348, investigating the interactions between food intake, daytime sleepiness, and nighttime sleep quali…

• CLINICAL_TRIALS trial_result · 2024-09-19
  Clinical Trial Update: A Phase 3 Study to Assess the Safety and Efficacy of Pitolisant in Adult Patients With Idiopathic Hypersomnia [Phase 3]

  This clinical trial update notes the completion of a Phase 3 study evaluating pitolisant for safety and efficacy in adults with idiopathic h…

• CLINICAL_TRIALS trial_result · 2024-09-19
  Clinical Trial Update: Efficacy and Tolerance of Solriamfetol in Patients Affected with Idiopathic Hypersomnia. [Phase 2]

  Phase 2 trial evaluating the efficacy and tolerance of solriamfetol in idiopathic hypersomnia; the study is currently not yet recruiting.

• CLINICAL_TRIALS research · 2024-05-29
  Clinical Trial Update: Spectrometry (MRM) Versus I 125 Radioimmunoassay (RIA) for Quantification of Orexin-A of Patients With Hypersomnolence [NA]

  This clinical trial compares a spectrometry-based method (MRM) to the I-125 radioimmunoassay for quantifying Orexin-A in patients with hyper…