Hypoxic-ischemic Encephalopathy
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CLINICAL_TRIALS trial_result · 2023-04-21Clinical Trial Update: Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns [Phase 2, Phase 3]
A Phase 2/Phase 3 trial evaluated hydrocortisone for treating systemic hypotension during hypothermia in asphyxiated newborns with hypoxic-i…
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CLINICAL_TRIALS trial_result · 2022-01-26Clinical Trial Update: Holding, Stress, and Bonding During Therapeutic Hypothermia [NA]
This clinical trial update describes a study on holding, stress, and bonding during therapeutic hypothermia for Hypoxic-Ischemic Encephalopa…
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CLINICAL_TRIALS trial_result · 2021-01-12Clinical Trial Update: Beneficial Effect of Intravenous Magnesium Sulphate in Term Neonates With Hypoxic Ischemic Encephalopathy(HIE) [Phase 2]
Phase 2 trial reporting beneficial effect of intravenous magnesium sulfate in term neonates with hypoxic-ischemic encephalopathy (HIE).
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CLINICAL_TRIALS trial_result · 2020-07-13Clinical Trial Update: Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO) [Phase 1, Phase 2]
Phase 1/2 trial NEATO evaluated neonatal erythropoietin with therapeutic hypothermia for brain injury due to hypoxic-ischemic events; study …
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CLINICAL_TRIALS trial_result · 2018-06-21Clinical Trial Update: Clinical Utility of Serum Biomarkers for the Management of Neonatal Hypoxic Ischemic Encephalopathy (Control Levels)
Completed clinical trial evaluating the clinical utility of serum biomarkers to guide management of neonatal Hypoxic Ischemic Encephalopathy…
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CLINICAL_TRIALS trial_result · 2018-05-02Clinical Trial Update: Correlation of Risk Factors and Severity of Hypoxic-ischaemic Encephalopathy
This completed clinical trial examined how various risk factors relate to the severity of Hypoxic-ischemic encephalopathy.
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CLINICAL_TRIALS trial_result · 2018-04-05Clinical Trial Update: Hyperbaric Oxygen Therapy Improves Outcome of Hypoxic-Ischemic Encephalopathy [NA]
This entry provides an update on a clinical trial evaluating hyperbaric oxygen therapy for hypoxic-ischemic encephalopathy, with the current…
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CLINICAL_TRIALS trial_result · 2018-04-03Clinical Trial Update: Reno-protective Effect of Brain Cooling in Newborn With Hypoxia
A completed clinical trial evaluating whether brain cooling offers reno-protection in newborns with hypoxic-ischemic encephalopathy.
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CLINICAL_TRIALS trial_result · 2018-01-05Clinical Trial Update: Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia [Phase 1, Phase 2]
A clinical trial evaluating the safety of clonidine in infants with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia has c…
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CLINICAL_TRIALS trial_result · 2017-07-06Clinical Trial Update: Protein Supplementation in Infants With Brain Injury [NA]
A completed clinical trial investigating protein supplementation in infants with brain injury, including perinatal stroke and hypoxic-ischem…
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CLINICAL_TRIALS trial_result · 2017-02-02Clinical Trial Update: Clinical Trial of a New Rectum Cooling System on Patients of Hypoxic-ischemic Brain Damage [NA]
A clinical trial evaluating a rectum cooling system for hypoxic-ischemic encephalopathy has completed.
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CLINICAL_TRIALS trial_result · 2017-01-26Clinical Trial Update: Autologous Cord Blood Cells for Brain Injury in Term Newborns [Phase 1]
Phase 1 study evaluating autologous cord blood cell therapy for brain injury in term newborns with hypoxic ischemic encephalopathy. The tria…
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CLINICAL_TRIALS trial_result · 2017-01-12Clinical Trial Update: Dexmedetomidine Pharmacokinetics in Neonates During Therapeutic Hypothermia [EARLY_Phase 1]
An early phase 1 trial examining dexmedetomidine pharmacokinetics in neonates during therapeutic hypothermia for hypoxic-ischemic encephalop…
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CLINICAL_TRIALS trial_result · 2016-10-14Clinical Trial Update: Magnesium Sulphate in Perinatal Asphyxia [Phase 3]
This update reports the completion of a Phase 3 trial evaluating magnesium sulfate for perinatal asphyxia in moderate to severe hypoxic-isch…
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CLINICAL_TRIALS trial_result · 2016-09-26Clinical Trial Update: Home Stimulation for Brain-Asphyxiated Infants [Phase 2]
A Phase 2 trial evaluating home stimulation therapy for infants with hypoxic-ischemic brain injury has completed. The study was sponsored by…
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CLINICAL_TRIALS trial_result · 2016-09-05Clinical Trial Update: NeoAdapt 3: Novel Biomarkers in the Evaluation of Neonatal Circulatory Insufficiency in Babies Suffering From Hypoxic Ischemic Encephalopathy
The NeoAdapt 3 trial evaluating novel biomarkers for neonatal circulatory insufficiency in babies with hypoxic-ischemic encephalopathy has c…
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CLINICAL_TRIALS trial_result · 2016-07-29Clinical Trial Update: Infant Heart Surgery: Central Nervous System Sequelae of Circulatory Arrest [Phase 3]
Phase 3 trial completed evaluating central nervous system sequelae after circulatory arrest in infants undergoing heart surgery.
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CLINICAL_TRIALS trial_result · 2016-05-11Clinical Trial Update: TOBY (TOtal Body hYpothermia): a Study of Treatment for Perinatal Asphyxia [NA]
This update confirms the completion of the TOBY trial evaluating whole-body therapeutic hypothermia for perinatal asphyxia and notes that re…
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CLINICAL_TRIALS trial_result · 2016-01-21Clinical Trial Update: The TOBY Children Study
The TOBY Children Study update reports the long-term follow-up results of therapeutic hypothermia in neonates with hypoxic-ischemic encephal…
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CLINICAL_TRIALS trial_result · 2015-07-16Clinical Trial Update: Hypothermia Enhanced by Magnesium Sulphate [Phase 2, Phase 3]
A Phase 2/Phase 3 trial evaluating hypothermia enhanced with magnesium sulfate for hypoxic-ischemic encephalopathy has completed.
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CLINICAL_TRIALS trial_result · 2015-05-22Clinical Trial Update: Darbe Administration in Newborns Undergoing Cooling for Encephalopathy [Phase 1, Phase 2]
A Phase 1/2 trial evaluating darbepoetin alfa administration in newborns undergoing therapeutic cooling for hypoxic ischemic encephalopathy,…
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CLINICAL_TRIALS trial_result · 2014-12-08Clinical Trial Update: California Transport Cooling Trial [NA]
A Stanford-led clinical trial on cooling therapy for hypoxic ischemic encephalopathy completed and posted results.
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CLINICAL_TRIALS trial_result · 2014-07-31Clinical Trial Update: Neonatal Resuscitation in Zambia [Phase 3]
Phase 3 clinical trial in Zambia evaluating neonatal resuscitation has completed, with outcomes relevant to asphyxia neonatorum and hypoxic …
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CLINICAL_TRIALS trial_result · 2014-07-31Clinical Trial Update: Pilot Study of Head Cooling in Preterm Infants With Hypoxic Ischemic Encephalopathy [Phase 1]
A Phase 1 pilot study of head cooling in preterm infants with hypoxic ischemic encephalopathy has completed with results posted.
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CLINICAL_TRIALS trial_result · 2013-12-13Clinical Trial Update: Safety and Efficacy of Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia [Phase 2]
Phase 2 study assessing safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with therapeutic hypother…