Hypothalamic Obesity
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CLINICAL_TRIALS trial_result · 2026-02-12Clinical Trial Update: A Study to Assess Efficacy and Safety of LB54640 in Patients With Hypothalamic Obesity [Phase 2]
A Phase 2 clinical trial update reports on the efficacy and safety of LB54640 in adults with hypothalamic obesity; the study has completed e…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756) [Phase 3]
Phase 3 trial update of setmelanotide for congenital hypothalamic obesity, including related pituitary hormone deficiency conditions, curren…
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CLINICAL_TRIALS research · 2026-02-10Clinical Trial Update: A Long-Term Study of Bivamelagon in Participants With Hypothalamic Obesity (HO) [Phase 2]
Phase 2 long-term study of bivamelagon in hypothalamic obesity is currently enrolling by invitation.
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment [Phase 1, Phase 2]
A Clinical Trial Update indicates RM-718 is being studied in Phase 1/Phase 2 in healthy subjects and patients with MC4R pathway impairment, …
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Tirzepatide in PWS, HO and GNSO [Phase 4]
Phase 4 clinical trial evaluating tirzepatide for Prader-Willi Syndrome and hypothalamic obesity is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-07-28Clinical Trial Update: Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity [Phase 2]
Phase 2 trial evaluating the efficacy and safety of phentermine/topiramate in youths with hypothalamic obesity, including patients with hypo…
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CLINICAL_TRIALS research · 2025-07-02Clinical Trial Update: A Trial of Setmelanotide in Acquired Hypothalamic Obesity [Phase 3]
Rhythm Pharmaceuticals provides an update on a Phase 3 trial of setmelanotide for hypothalamic obesity, with the study currently active but …
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CLINICAL_TRIALS trial_result · 2023-09-21Clinical Trial Update: Open-Label Study of Setmelanotide in Hypothalamic Obesity [Phase 2]
Rhythm Pharmaceuticals completed an open-label Phase 2 study of setmelanotide in hypothalamic obesity and posted the results in 2023. The up…
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CLINICAL_TRIALS trial_result · 2022-10-05Clinical Trial Update: Intranasal Oxytocin in Hypothalamic Obesity [Phase 2]
Phase 2 clinical trial investigating intranasal oxytocin for hypothalamic obesity associated with craniopharyngioma has completed with resul…
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CLINICAL_TRIALS trial_result · 2022-05-05Clinical Trial Update: Energy Balance & Weight Loss in Craniopharyngioma-related or Other Hypothalamic Tumors in Hypothalamic Obesity [Phase 3]
Phase 3 trial in hypothalamic obesity evaluating energy balance and weight loss in craniopharyngioma-related or other hypothalamic tumors; s…
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CLINICAL_TRIALS trial_result · 2018-10-16Clinical Trial Update: Efficacy and Safety of Exenatide in the Treatment of Hypothalamic Obesity After Craniopharyngioma Therapy [Phase 3]
Phase 3 trial assessing efficacy and safety of exenatide for hypothalamic obesity after craniopharyngioma therapy has been completed.
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CLINICAL_TRIALS trial_result · 2017-11-17Clinical Trial Update: Hypothalamic Obesity Following Craniopharyngioma Surgery: A Pilot Trial of Combined Metformin and Diazoxide Therapy [Phase 2]
Phase 2 pilot trial evaluating combined metformin and diazoxide therapy for hypothalamic obesity after craniopharyngioma surgery; the study …
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CLINICAL_TRIALS trial_result · 2016-07-18Clinical Trial Update: An Efficacy, Safety, and Pharmacokinetics Study of Beloranib in Obese Subjects With Hypothalamic Injury [Phase 2]
A Phase 2 study evaluated beloranib for efficacy, safety, and pharmacokinetics in obese subjects with hypothalamic injury, including craniop…
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CLINICAL_TRIALS trial_result · 2016-03-21Clinical Trial Update: Effects of Exenatide on Hypothalamic Obesity [Phase 1, Phase 2]
Phase 1/2 trial assessing exenatide for hypothalamic obesity has completed with results posted in 2016.
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CLINICAL_TRIALS trial_result · 2013-10-22Clinical Trial Update: Effects of Exenatide on Obesity and/or Diabetes Mellitus Due to Hypothalamic Damage [NA]
This clinical trial update concerns the use of exenatide for hypothalamic obesity and diabetes mellitus, but no status or results are provid…
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CLINICAL_TRIALS trial_result · 2012-04-30Clinical Trial Update: A Study of Octreotide Depot vs Saline Control in Pediatric Hypothalamic Obesity Patients [Phase 4]
Phase 4 trial comparing octreotide depot to saline control in pediatric hypothalamic obesity has completed.
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CLINICAL_TRIALS trial_result · 2011-09-12Clinical Trial Update: Pediatric Hypothalamic Obesity [Phase 4]
Phase 4 clinical trial update for pediatric hypothalamic obesity sponsored by Novartis, indicating the study has completed.