Hyponatremia
📧 Sign up to get email alerts when something new happens for Hyponatremia.
Sign up freeTop drugs studied for this disease
-
CLINICAL_TRIALS research · 2012-10-30Clinical Trial Update: Tolvaptan for Hyponatremia in Cirrhotic Patients With Ascites [Phase 4]
A Phase 4 clinical trial update investigating tolvaptan for hyponatremia in cirrhotic patients with ascites.
-
CLINICAL_TRIALS trial_result · 2012-10-17Clinical Trial Update: Do Changes in Plasma Osmolality Influence Ventilation? [EARLY_Phase 1]
A completed early-phase clinical trial investigates whether changes in plasma osmolality affect ventilation.
-
CLINICAL_TRIALS trial_result · 2012-06-13Clinical Trial Update: Hypotonic Versus Isotonic Parenteral (HIP) Fluid Trial [Phase 3]
Phase 3 trial comparing hypotonic versus isotonic parenteral fluids for hyponatremia and hypernatremia has completed; results were posted in…
-
CLINICAL_TRIALS trial_result · 2012-05-03Clinical Trial Update: "SALT-2 Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia [Phase 3]
Phase 3 SALT-2 trial evaluating ascending doses of tolvaptan for hyponatremia has completed.
-
CLINICAL_TRIALS trial_result · 2012-03-07Clinical Trial Update: 0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Critically Ill Children [NA]
Completed pediatric trial comparing maintenance IV fluids—0.9% sodium chloride with 5% dextrose vs 0.45% sodium chloride with 5% dextrose—in…
- Want full summaries, importance scores, and drug timelines? Upgrade to Plus or Pro.
-
FDA label_change · 2012-02-01FDA Approved: SAMSCA — Supplemental Application (Otsuka America Pharmaceutical, Inc.)
FDA approved a supplemental application for SAMSCA (tolvaptan) to update the labeling, including changes to indications or safety informatio…
-
CLINICAL_TRIALS trial_result · 2012-01-25Clinical Trial Update: Variation in Natremia Using Two Different Maintenance Intravenous Fluids in Postsurgical Hospitalized Children [Phase 3]
Phase 3 clinical trial comparing two maintenance intravenous fluids in postsurgical hospitalized children with hyponatremia; results on natr…
-
CLINICAL_TRIALS trial_result · 2012-01-12Clinical Trial Update: The Clinical and Laboratory Characteristics of Recurrent Drug- Related Hyponatremia
This clinical trial update describes the clinical and laboratory characteristics of recurrent drug-related hyponatremia, including hyponatre…
-
CLINICAL_TRIALS trial_result · 2012-01-11Clinical Trial Update: Efficacy and Safety Study of the Tolvaptan Tablets in Patients With Non-hypovolemic Non-acute Hyponatremia [Phase 2, Phase 3]
It describes a Phase 2/Phase 3 trial evaluating the efficacy and safety of tolvaptan tablets in patients with non-hypovolemic non-acute hypo…
-
CLINICAL_TRIALS trial_result · 2011-10-26Clinical Trial Update: Post Operative Hyponatremia in the Renal Transplant Population
This Mayo Clinic-sponsored clinical trial evaluated post-operative hyponatremia in renal transplant patients and has completed, with results…
-
FDA label_change · 2011-09-23FDA Approved: SAMSCA — Supplemental Application (Otsuka America Pharmaceutical, Inc.)
FDA approved a supplemental application for SAMSCA (tolvaptan) submitted by Otsuka America Pharmaceutical, resulting in updated labeling for…
-
CLINICAL_TRIALS trial_result · 2011-08-30Clinical Trial Update: Pseudohyponatremia of Multiple Myeloma is True Hyponatremia
A clinical trial update concludes that hyponatremia observed in patients with multiple myeloma is true hyponatremia rather than pseudohypona…
-
CLINICAL_TRIALS trial_result · 2011-08-05Clinical Trial Update: Maintenance Intravenous Fluids in Children [Phase 3]
A Phase 3 trial evaluating maintenance intravenous fluids in children with hyponatremia has completed, with results posted in 2011.
-
CLINICAL_TRIALS trial_result · 2011-07-06Clinical Trial Update: Polymorphisms of the Thiazide's Receptor Gene SLC12A3 and Development of Hyponatremia
Completed clinical trial investigating how polymorphisms in the SLC12A3 gene (thiazide transporter) influence the development of hyponatremi…
-
CLINICAL_TRIALS trial_result · 2011-06-28Clinical Trial Update: THE BALANCE Study: Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV Cardiac Patient Evaluation [Phase 3]
Phase 3 clinical trial update on lixivaptan for treating hyponatremia in NYHA Class III/IV heart failure patients; study completed.
-
CLINICAL_TRIALS trial_result · 2011-06-28Clinical Trial Update: Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Oral Lixivaptan Capsules in Subject With Euvolemic Hyponatremia [Phase 3]
A Phase 3 multicenter, randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of oral lixivaptan capsules in a…
-
CLINICAL_TRIALS trial_result · 2011-06-21Clinical Trial Update: International, Multicenter Study of a Twenty-eight Week, Open-label, Titrated Oral Lixivaptan Administration in Patients With Chronic Hyponatremia: Extension to Studies CK-LX3401, 3405, and 3430
An international, multicenter extension study evaluated lixivaptan in patients with chronic hyponatremia and completed a 28-week open-label …
-
CLINICAL_TRIALS trial_result · 2011-04-28Clinical Trial Update: Effects of Titrated Oral Tolvaptan 15-60 mg Once Daily (QD) on Cognitive and Neurological Function in Elderly Hyponatremic Patients [Phase 3]
Phase 3 trial evaluating titrated oral tolvaptan (15-60 mg QD) on cognitive and neurological function in elderly patients with hyponatremia;…
-
CLINICAL_TRIALS trial_result · 2011-04-26Clinical Trial Update: Subclassification of the Syndrome of Inappropriate ADH Secretion
This clinical trial update indicates completion of a study on subclassifying the syndrome of inappropriate antidiuretic hormone secretion (S…
-
CLINICAL_TRIALS withdrawal · 2010-11-23Clinical Trial Update: International, Multicenter, Open-Label and Randomized Withdrawal Study of Oral Lixivaptan in Heart Failure Patients With Chronic Hyponatremia [Phase 3]
An international Phase 3 trial evaluating oral lixivaptan for hypervolemic hyponatremia in heart failure patients has been withdrawn.
-
CLINICAL_TRIALS trial_result · 2010-10-01Clinical Trial Update: Safety and Efficacy of Conivaptan in Hyponatremic Patients With Symptomatic Acute Decompensated Heart Failure (ADHF) [Phase 3]
Phase 3 trial of conivaptan in hyponatremic patients with symptomatic acute decompensated heart failure was terminated; results were posted.
-
CLINICAL_TRIALS trial_result · 2010-09-27Clinical Trial Update: Use of Conivaptan (Vaprisol) for Hyponatremic Neuro-ICU Patients [Phase 4]
Phase 4 trial update on using conivaptan (Vaprisol) for hyponatremic neuro-ICU patients; study terminated with results posted in 2010.
-
CLINICAL_TRIALS trial_result · 2010-05-26Clinical Trial Update: A Study of Multiple Dosing Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia [Phase 4]
Phase 4 clinical trial update reporting results from multiple dosing regimens of IV conivaptan in patients with euvolemic or hypervolemic hy…
-
CLINICAL_TRIALS trial_result · 2010-04-21Clinical Trial Update: Study of Efficacy & Safety for 3 Infusion Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia [Phase 3]
A Phase 3 trial evaluated three infusion regimens of IV conivaptan for euvolemic or hypervolemic hyponatremia and posted efficacy and safety…
-
FDA approval · 2009-05-19FDA Approved: SAMSCA — Original Application (Otsuka America Pharmaceutical, Inc.)
FDA approved Samsca (tolvaptan) from Otsuka America for the treatment of clinically significant hyponatremia in adults, including hyponatrem…