Hyponatremia
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CLINICAL_TRIALS withdrawal · 2019-02-06Clinical Trial Update: Fractional Urate Excretion in Nonedematous Hyponatremia [NA]
A clinical trial evaluating fractional urate excretion in nonedematous hyponatremia was withdrawn. The study involved cerebral hyponatremia …
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CLINICAL_TRIALS trial_result · 2018-08-28Clinical Trial Update: Study of the Safety and Effectiveness of SAMSCA® (Tolvaptan) in Children and Adolescents With Euvolemic or Hypervolemic Hyponatremia [Phase 3]
Phase 3 pediatric trial of tolvaptan (SAMSCA) for hyponatremia was terminated; results were posted.
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CLINICAL_TRIALS trial_result · 2018-08-10Clinical Trial Update: Regional Tolvaptan Registry [Phase 4]
Phase 4 trial update for a regional registry evaluating tolvaptan in patients with decompensated heart failure and hyponatremia.
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CLINICAL_TRIALS research · 2018-08-06Clinical Trial Update: An Observational Study to Describe the Adherence to the SEOM Algorithm for the Treatment of Hyponatraemia in Spain
An observational trial assessing adherence to the SEOM algorithm for treating hyponatremia in Spain, completed with posted results in 2018.
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CLINICAL_TRIALS trial_result · 2018-04-26Clinical Trial Update: Beer for Endurance Exercise Recovery [NA]
A completed clinical trial from SUNY Upstate Medical University evaluating beer as a recovery beverage for endurance exercise, with hyponatr…
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FDA approval · 2018-04-23FDA Approved: SAMSCA — Supplemental Application (Otsuka America Pharmaceutical, Inc.)
FDA approved a supplemental application for Samsca (tolvaptan) from Otsuka America Pharmaceutical.
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CLINICAL_TRIALS trial_result · 2018-04-04Clinical Trial Update: An Observational Study Measuring Outcomes in Cancer Patients Treated for Moderate to Severe Hyponatremia in Italy
An observational study conducted in Italy assessed outcomes for cancer patients treated for moderate to severe hyponatremia (often due to SI…
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CLINICAL_TRIALS trial_result · 2018-02-05Clinical Trial Update: An Observational Study on Real-world Use and Outcomes of Patients Treated With Tolvaptan for Hyponatraemia Due to SIADH
An observational real-world study evaluated outcomes in patients treated with tolvaptan for hyponatremia due to SIADH, with results posted i…
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CLINICAL_TRIALS trial_result · 2017-08-29Clinical Trial Update: Hyponatremia in the Prevention of Hospitalized Patients Falls [NA]
A completed clinical trial investigating the role of hyponatremia in preventing falls among hospitalized patients.
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CLINICAL_TRIALS withdrawal · 2017-07-31Clinical Trial Update: A Trial of Tolvaptan in Children and Adolescent Subjects With Euvolemic and Hypervolemic Hyponatremia [Phase 3]
A Phase 3 trial of tolvaptan for euvolemic and hypervolemic hyponatremia in children and adolescents has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2017-06-14Clinical Trial Update: Outcome and Treatment Quality Study of Tolvaptan to Treat Hyponatremia in Patients With Heart Failure [Phase 4]
Phase 4 clinical trial evaluating tolvaptan for hyponatremia in heart failure has been terminated.
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FDA approval · 2017-06-01FDA Approved: SAMSCA — Supplemental Application (Otsuka America Pharmaceutical, Inc.)
FDA approved a supplemental application for SAMSCA (tolvaptan) from Otsuka America Pharmaceutical, Inc., likely updating labeling or expandi…
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CLINICAL_TRIALS trial_result · 2016-12-16Clinical Trial Update: Use of Isotonic Solutions Versus Hypotonic Solutions for Preventing Hospital Acquired Hyponatremia [Phase 3]
Phase 3 trial comparing isotonic versus hypotonic IV fluids to prevent hospital-acquired hyponatremia has completed, with results posted.
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CLINICAL_TRIALS trial_result · 2016-12-15Clinical Trial Update: Tolvaptan for In-hospital Hyponatremia [Phase 2]
Phase 2 trial of tolvaptan for in-hospital hyponatremia has been terminated.
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CLINICAL_TRIALS research · 2016-10-18Clinical Trial Update: Comparison of Ringer Lactate and Isotonic Acetate Solution as Perioperative Maintenance Fluid for Children [NA]
This clinical trial update compares Ringer Lactate with Isotonic Acetate Solution as perioperative maintenance fluids in children with hypon…
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CLINICAL_TRIALS trial_result · 2016-09-08Clinical Trial Update: Pharmacokinetics and Clinical Response of Tolvaptan in Neurocritical Care Patients
A terminated clinical trial evaluating the pharmacokinetics and clinical response of tolvaptan in neurocritical care patients with brain inj…
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CLINICAL_TRIALS trial_result · 2016-08-18Clinical Trial Update: Effect of Midodrine and Albumine in the Prevention of Complications in Cirrhotic Patients Awaiting Liver Transplantation [Phase 4]
A Phase 4 clinical trial evaluated midodrine plus albumin to prevent complications in patients with liver cirrhosis awaiting transplantation…
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CLINICAL_TRIALS trial_result · 2016-08-10Clinical Trial Update: Effects of Empagliflozin an SGLT2-Inhibitor on Healthy Volunteers With Induced Hypotonic Hyponatremia - the DIVE Study [Phase 2, Phase 3]
A completed Phase 2/3 clinical trial (the DIVE study) evaluated the effects of empagliflozin, an SGLT2 inhibitor, in healthy volunteers with…
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CLINICAL_TRIALS trial_result · 2016-05-26Clinical Trial Update: A Phase III Study Evaluating the Efficacy and Safety of Satavaptan Versus Placebo in Patients With Dilutional Hyponatremia [Phase 3]
A Phase III study evaluating satavaptan versus placebo in patients with dilutional hyponatremia was terminated.
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CLINICAL_TRIALS trial_result · 2016-05-12Clinical Trial Update: V2 Receptor Effects on Fluid Regulation and Performance [NA]
A completed study evaluated the effects of vasopressin V2 receptor activity on fluid regulation and performance; results were posted in 2016…
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CLINICAL_TRIALS trial_result · 2016-05-09Clinical Trial Update: Hyponatremia and Hypoalbuminemia is Morbimortality Predictors in Coronary Artery Bypass Graft Surgery
A clinical trial update reports that hyponatremia and hypoalbuminemia are predictors of morbimortality in coronary artery bypass graft surge…
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CLINICAL_TRIALS trial_result · 2016-04-11Clinical Trial Update: Tolvaptan to Reduce Length of Stay in Hospitalized Patients With Cirrhosis and Hyponatremia [Phase 4]
Phase 4 trial evaluating whether tolvaptan reduces hospital length of stay in patients with cirrhosis and hyponatremia. The study was termin…
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CLINICAL_TRIALS trial_result · 2016-03-01Clinical Trial Update: A Study to Assess the Efficacy, Safety and Pharmacokinetics of Intravenous Conivaptan (Vaprisol®) in Pediatric Subjects With Euvolemic or Hypervolemic Hyponatremia [Phase 3]
A Phase 3 study of intravenous conivaptan (Vaprisol) in pediatric patients with euvolemic or hypervolemic hyponatremia was terminated, with …
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CLINICAL_TRIALS trial_result · 2016-02-11Clinical Trial Update: Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage: [Phase 1, Phase 2]
This clinical trial update discusses the safety and feasibility of using hypertonic saline solution in patients after aneurysmal subarachnoi…
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CLINICAL_TRIALS withdrawal · 2016-01-29Clinical Trial Update: Reexamining Hypotonic Intravenous Fluid Use [NA]
A clinical trial evaluating the use of hypotonic intravenous fluids for hyponatremia was withdrawn from the study database.