Hypoglycemia Unawareness
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Update: Adrenergic System in Islet Transplantation [EARLY_Phase 1]
Early-phase trial investigating the adrenergic system in islet transplantation for type 1 diabetes, with completed status and posted results…
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Results: Adrenergic System in Islet Transplantation [EARLY_Phase 1]
Early-phase trial results from a study on the adrenergic system in islet transplantation for type 1 diabetes and hypoglycemia-related condit…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Restoration of Hypoglycemia Awareness With Metoclopramide [Phase 2]
A Phase 2 clinical trial is evaluating whether metoclopramide can restore hypoglycemia awareness in individuals with hypoglycemia unawarenes…
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CLINICAL_TRIALS trial_result · 2026-01-08Clinical Trial Update: Restoration of Hypoglycemia Awareness With Home-based High Intensity Interval Training [NA]
A completed study assessing whether home-based high-intensity interval training can restore hypoglycemia awareness in people with type 1 dia…
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CLINICAL_TRIALS trial_result · 2025-09-11Clinical Trial Update: Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF) [Phase 4]
Phase 4 trial evaluating a novel approach to prevent hypoglycemia-associated autonomic failure in people with type 1 diabetes was terminated…
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CLINICAL_TRIALS research · 2025-08-22Clinical Trial Update: A Safety, Tolerability, and Efficacy Study of E-islet 01 in Participants With Type 1 Diabetes [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating the safety, tolerability, and efficacy of E-islet 01 in participants with Type 1 diabetes and impaired…
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CLINICAL_TRIALS trial_result · 2025-08-12Clinical Trial Update: Allogeneic Islet Cells Transplanted Onto the Omentum [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating allogeneic pancreatic islet cell transplantation onto the omentum for type 1 diabetes has completed wi…
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CLINICAL_TRIALS research · 2025-07-03Clinical Trial Update: Regulation of Brain Glucose Metabolism in Type 1 Diabetes [EARLY_Phase 1]
An early-phase (Phase 1) Yale study investigating regulation of brain glucose metabolism in people with Type 1 diabetes and hypoglycemia una…
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CLINICAL_TRIALS research · 2025-02-13Clinical Trial Update: Adrenergic System in Islet Transplantation [EARLY_Phase 1]
A Phase 1 clinical trial update exploring the adrenergic system in islet transplantation for type 1 diabetes and related hypoglycemia condit…
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CLINICAL_TRIALS trial_result · 2024-12-03Clinical Trial Update: A Safety, Tolerability, and Efficacy Study of VC-02™ Combination Product in Subjects With Type 1 Diabetes Mellitus and Hypoglycemia Unawareness [Phase 1, Phase 2]
ViaCyte's VC-02 combination product for type 1 diabetes mellitus with hypoglycemia unawareness has completed its Phase 1/2 safety, tolerabil…
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CLINICAL_TRIALS trial_result · 2023-09-28Clinical Trial Update: Hybrid Closed Loop Insulin Delivery System in Hypoglycemia [NA]
This clinical trial update reports results for a hybrid closed-loop insulin delivery system studied in people with Type 1 diabetes and hypog…
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CLINICAL_TRIALS trial_result · 2023-08-31Clinical Trial Update: Glucose Counterregulation in Long Standing Type 1 Diabetes [NA]
A completed clinical trial from University of Pennsylvania studied glucose counterregulation in long-standing Type 1 diabetes, with results …
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CLINICAL_TRIALS trial_result · 2023-03-27Clinical Trial Update: Intra-nasal Naloxone for Treatment of Impaired Awareness of Hypoglycemia [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating intranasal naloxone for treating impaired awareness of hypoglycemia in type 1 diabetes was terminated,…
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CLINICAL_TRIALS trial_result · 2021-02-21Clinical Trial Update: Glucagon Infusion in T1D Patients With Recurrent Severe Hypoglycemia: Effects on Counter-Regulatory Responses [Phase 2]
Phase 2 trial on glucagon infusion in type 1 diabetes patients with recurrent severe hypoglycemia; study terminated with results posted.
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CLINICAL_TRIALS trial_result · 2020-09-09Clinical Trial Update: Carvedilol in Treating Hypoglycemia Unawareness [Phase 2]
Phase 2 trial evaluating carvedilol for hypoglycemia unawareness was terminated; results posted in 2020.
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CLINICAL_TRIALS trial_result · 2020-03-23Clinical Trial Update: Effect of Dapagliflozin on IAH in T1DM [Phase 2]
Phase 2 trial investigating the effect of dapagliflozin on impaired awareness of hypoglycemia in adults with type 1 diabetes; study complete…
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CLINICAL_TRIALS trial_result · 2020-01-31Clinical Trial Update: A Randomized Double Blinded Study to Examine the Use of N-acetyl Cysteine for the Prevention and Treatment of HAAF in Patients With Type 1 Diabetes [Phase 1, Phase 2]
A randomized double-blind study assessing N-acetyl cysteine for prevention and treatment of hypoglycemia unawareness in type 1 diabetes (pha…
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CLINICAL_TRIALS trial_result · 2019-07-22Clinical Trial Update: Amitriptyline in Treating Hypoglycemia [Phase 2]
A Phase 2 trial evaluating amitriptyline for hypoglycemia in individuals with type 1 diabetes and hypoglycemia unawareness was terminated wi…
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CLINICAL_TRIALS trial_result · 2017-07-26Clinical Trial Update: The Effects of RT-CGM on Glycemia and QoL in Patients With T1DM and IHA [NA]
A completed trial evaluating the impact of real-time continuous glucose monitoring on glycemia and quality of life in patients with Type 1 d…
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CLINICAL_TRIALS trial_result · 2016-11-25Clinical Trial Update: The Role of Endogenous Lactate in Brain Preservation and Counterregulatory Defenses Against Hypoglycemia [NA]
A completed clinical trial examining the role of endogenous lactate in brain preservation and counterregulatory responses to hypoglycemia in…
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CLINICAL_TRIALS trial_result · 2015-11-10Clinical Trial Update: The Effect of Hypoglycaemia on Brain Lactate Accumulation and Cerebral Blood Flow [NA]
This clinical trial investigated how hypoglycemia affects brain lactate accumulation and cerebral blood flow in people with Type 1 diabetes …
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CLINICAL_TRIALS trial_result · 2015-05-12Clinical Trial Update: The Effect of Antecedent Hypoglycaemia on β2-adrenergic Sensitivity [NA]
A completed trial investigated how antecedent hypoglycemia influences beta-2 adrenergic sensitivity in individuals with diabetes and hypogly…
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CLINICAL_TRIALS trial_result · 2014-09-12Clinical Trial Update: Naltrexone and Hypoglycemia in Type 1 Diabetes [Phase 1, Phase 2]
Clinical trial update on naltrexone for hypoglycemia in Type 1 diabetes, completed with results posted in 2014 (Phases 1 and 2).