Hyperinsulinemia
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CLINICAL_TRIALS trial_result · 2026-01-12Clinical Trial Update: Pancreatic Clamp in NAFLD [Phase 1]
Phase 1 clinical trial evaluating a pancreatic clamp approach in non-alcoholic fatty liver disease to study insulin resistance and related m…
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CLINICAL_TRIALS trial_result · 2026-01-07Clinical Trial Update: Glycemic Effect of Diazoxide in NAFLD [Phase 1]
A Phase 1 study evaluating the glycemic effects of diazoxide in individuals with hyperinsulinemia, insulin resistance, prediabetes, and non-…
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CLINICAL_TRIALS trial_result · 2025-12-10Clinical Trial Update: Link Between the Peripheral Mononuclear Cells' Capacity to Induce Insulin Resistance and Hyperinsulinemia [NA]
This update reports on a completed clinical trial investigating whether peripheral mononuclear cells can induce insulin resistance and hyper…
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CLINICAL_TRIALS trial_result · 2025-01-29Clinical Trial Update: Hyperinsulinemia in Prediabetes Mediated by Interleukin-1β [Phase 2]
A Phase 2 trial evaluating interleukin-1β–mediated hyperinsulinemia in individuals with prediabetes has completed. The update provides the s…
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CLINICAL_TRIALS trial_result · 2023-06-01Clinical Trial Update: Reprometabolic Syndrome Mediates Subfertility in Obesity [NA]
This clinical trial update discusses reprometabolic syndrome as a mediator of subfertility in obesity. The trial's results were posted in 20…
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CLINICAL_TRIALS trial_result · 2016-05-13Clinical Trial Update: Lipoprotein Metabolism in Hypertensive African-Americans
This is a completed NHLBI clinical trial update about lipoprotein metabolism in hypertensive African-Americans.
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CLINICAL_TRIALS trial_result · 2016-02-10Clinical Trial Update: Central Obesity and Disease Risk in Japanese Americans
This completed clinical trial investigated how central obesity relates to the risk of cardiovascular and metabolic diseases in Japanese Amer…
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CLINICAL_TRIALS trial_result · 2016-01-21Clinical Trial Update: Maternal Lifestyle and Neonatal Hypoglycemia [NA]
This completed clinical trial evaluated whether maternal lifestyle factors influence neonatal hypoglycemia and related pregnancy outcomes. T…
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CLINICAL_TRIALS trial_result · 2013-07-22Clinical Trial Update: Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Patients With Insulin and Fat Abnormalities [NA]
This study evaluated metformin and rosiglitazone, alone or in combination, in HIV-infected patients with insulin resistance and lipodystroph…
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CLINICAL_TRIALS trial_result · 2012-09-06Clinical Trial Update: Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With Hyperinsulinemia
The completed trial analyzes spectroscopic and colorimetric assessment of acanthosis nigricans in patients with hyperinsulinemia.
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CLINICAL_TRIALS trial_result · 2011-04-07Clinical Trial Update: Metformin to Treat Obesity in Children With Insulin Resistance [Phase 2]
Phase 2 trial evaluating metformin for obesity in children with insulin resistance has completed and results have been posted.
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CLINICAL_TRIALS trial_result · 2009-02-18Clinical Trial Update: Metabolic Effect of Metformin in Obese Insulin Resistant Adolescents With Normal Glucose Tolerance [Phase 4]
Phase 4 study evaluating the metabolic effects of metformin in obese, insulin-resistant adolescents with normal glucose tolerance.
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CLINICAL_TRIALS trial_result · 2008-06-24Clinical Trial Update: Effects of a Comprehensive Weight Management Program on Obese Adolescents and Children [NA]
This clinical trial update notes the completion of a study evaluating a comprehensive weight management program for obese children and adole…
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CLINICAL_TRIALS trial_result · 2008-03-04Clinical Trial Update: Effect of Insulin on Endothelin-Dependent Vascular Tone in the Forearm Circulation [Phase 1]
Phase 1 study assessing the effect of insulin on endothelin-dependent vascular tone in the forearm; the trial has completed.
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CLINICAL_TRIALS trial_result · 2008-03-04Clinical Trial Update: Health Effects of Liposuction in Overweight Women With Elevated Insulin Levels, Impaired Glucose Tolerance and/or Type 2 Diabetes
A completed clinical trial evaluating the health effects of liposuction in overweight women with elevated insulin levels, impaired glucose t…