Homozygous Familial Hypercholesterolemia
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CLINICAL_TRIALS trial_result · 2026-03-31Clinical Trial Update: Cardiovascular Evaluation of Patients With High Cholesterol and Normal Volunteers
The NHLBI-supported clinical trial completed an evaluation of cardiovascular health in patients with homozygous familial hypercholesterolemi…
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CLINICAL_TRIALS trial_result · 2026-03-20Clinical Trial Update: Study of Zodasiran in Adolescent Participants With Homozygous Familial Hypercholesterolemia [Phase 3]
A Phase 3 study of Zodasiran in adolescents with Homozygous Familial Hypercholesterolemia is not yet recruiting, according to sponsor Arrowh…
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CLINICAL_TRIALS trial_result · 2025-12-15Clinical Trial Update: A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Clinical Study Evaluating the Efficacy and Safety of SHR-1918 in Patients With Homozygous Familial Hypercholesterolemia [Phase 3]
A Phase III randomized trial evaluating efficacy and safety of SHR-1918 for homozygous familial hypercholesterolemia has completed.
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CLINICAL_TRIALS trial_result · 2025-09-05Clinical Trial Update: Evaluate the Efficacy and Safety of SHR-1918 in Patients With Homozygous Familial Hypercholesterolemia [Phase 2]
A Phase 2 clinical trial evaluating the efficacy and safety of SHR-1918 in patients with Homozygous Familial Hypercholesterolemia has comple…
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CLINICAL_TRIALS trial_result · 2025-08-27Clinical Trial Update: Efficacy and Safety of Lomitapide in Paediatric Patients With Homozygous Familial Hypercholesterolaemia (HoFH) [Phase 3]
Phase 3 trial evaluating lomitapide in pediatric patients with Homozygous familial hypercholesterolemia has completed. Results have been pos…
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CLINICAL_TRIALS trial_result · 2025-08-21Clinical Trial Update: Evaluate the Long-term Efficacy and Safety of SHR-1918 in Patients With Homozygous Familial Hypercholesterolemia [Phase 2]
Phase 2 clinical trial evaluating SHR-1918 for Homozygous Familial Hypercholesterolemia; the study is currently not yet recruiting.
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CLINICAL_TRIALS trial_result · 2025-05-31Clinical Trial Update: Study to Evaluate Efficacy and Safety of Inclisiran in Adolescents With Homozygous Familial Hypercholesterolemia [Phase 3]
A Phase 3 trial evaluating the efficacy and safety of inclisiran in adolescents with homozygous familial hypercholesterolemia has completed …
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CLINICAL_TRIALS trial_result · 2025-03-25Clinical Trial Update: Safety and Effectiveness of Evinacumab for the Treatment of Homozygous Familial Hypercholesterolemia [Phase 3]
This Phase 3 trial update reports safety and effectiveness data for evinacumab in Homozygous Familial Hypercholesterolemia; the trial is com…
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CLINICAL_TRIALS trial_result · 2024-12-02Clinical Trial Update: A Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of VSA003 in Chinese HoFH Patients [Phase 3]
A Phase 3 clinical trial to evaluate the efficacy and safety of VSA003 in Chinese patients with Homozygous Familial Hypercholesterolemia is …
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CLINICAL_TRIALS trial_result · 2024-07-24Clinical Trial Update: To Evaluate the Efficacy and Safety of JS002 in HoFH Patients [Phase 2]
Phase 2 clinical trial evaluating the efficacy and safety of JS002 in patients with homozygous familial hypercholesterolemia (HoFH) has comp…
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CLINICAL_TRIALS trial_result · 2024-04-30Clinical Trial Update: Evaluate the Long-Term Safety and Efficacy of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia [Phase 3]
A Phase 3 trial evaluating long-term safety and efficacy of evinacumab in homozygous familial hypercholesterolemia has completed, with resul…
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CLINICAL_TRIALS trial_result · 2023-08-09Clinical Trial Update: A Study to Evaluate Safety and Efficacy of IBI306, a PCSK9 Monoclonal Antibody in Chinese Subjects With Homozygous Familial Hypercholesterolemia [Phase 2, Phase 3]
A study evaluating safety and efficacy of IBI306, a PCSK9 monoclonal antibody, in Chinese subjects with homozygous familial hypercholesterol…
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CLINICAL_TRIALS trial_result · 2023-07-13Clinical Trial Update: A Gene Therapy Study for Homozygous Familial Hypercholesterolemia (HoFH) [Phase 1, Phase 2]
Phase 1/2 gene therapy trial for Homozygous Familial Hypercholesterolemia (HoFH) has been terminated; results posted in 2023.
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CLINICAL_TRIALS trial_result · 2023-06-07Clinical Trial Update: Evaluate the Efficacy and Safety of Evinacumab in Pediatric Patients With Homozygous Familial Hypercholesterolemia [Phase 3]
Phase 3 clinical trial results updating the efficacy and safety of evinacumab in pediatric patients with Homozygous Familial Hypercholestero…
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CLINICAL_TRIALS trial_result · 2023-03-29Clinical Trial Update: Phase 3 Study to Evaluate the Efficacy and Safety of LIB003 With Evolocumab in HoFH [Phase 3]
Phase 3 trial evaluating LIB003 with evolocumab in Homozygous Familial Hypercholesterolemia has completed.
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CLINICAL_TRIALS trial_result · 2023-03-02Clinical Trial Update: A Study to Evaluate the Safety and Efficacy of the PCSK9 Inhibitor AK102 in Patients With HoFH [Phase 2]
Phase 2 trial evaluating safety and efficacy of AK102, a PCSK9 inhibitor, in patients with homozygous familial hypercholesterolemia complete…
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CLINICAL_TRIALS trial_result · 2022-11-10Clinical Trial Update: A Study of Inclisiran in Participants With Homozygous Familial Hypercholesterolemia (HoFH) [Phase 3]
Phase 3 trial evaluating inclisiran for Homozygous Familial Hypercholesterolemia has completed with results posted.
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CLINICAL_TRIALS trial_result · 2021-06-29Clinical Trial Update: Study in Participants With Homozygous Familial Hypercholesterolemia (HoFH) [Phase 3]
A Phase 3 clinical trial in participants with homozygous familial hypercholesterolemia has completed and results were posted in 2021.
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CLINICAL_TRIALS trial_result · 2021-05-18Clinical Trial Update: Efficacy and Safety of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia [Phase 3]
Phase 3 trial updates on the efficacy and safety of evinacumab in patients with Homozygous Familial Hypercholesterolemia.
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CLINICAL_TRIALS trial_result · 2020-12-29Clinical Trial Update: An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial Hypercholesterolemia [Phase 3]
Phase 3 trial update evaluating alirocumab for efficacy and safety in children and adolescents with homozygous familial hypercholesterolemia…
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CLINICAL_TRIALS trial_result · 2020-11-03Clinical Trial Update: Safety and Tolerability of Repatha® (Evolocumab) in Indian Participants With Homozygous Familial Hypercholesterolemia [Phase 4]
Phase 4 trial update assessing safety and tolerability of Repatha (evolocumab) in Indian participants with Homozygous Familial Hypercholeste…
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CLINICAL_TRIALS trial_result · 2020-06-25Clinical Trial Update: Efficacy and Safety of Gemcabene in Patients With Homozygous Familial Hypercholesterolemia on Stable, Lipid-Lowering Therapy (COBALT-1) [Phase 2]
Phase 2 trial update on the efficacy and safety of gemcabene in patients with homozygous familial hypercholesterolemia on stable lipid-lower…
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CLINICAL_TRIALS trial_result · 2020-05-18Clinical Trial Update: A Study of ALN-PCSSC in Participants With Homozygous Familial Hypercholesterolemia (HoFH) [Phase 2]
Phase 2 trial update for ALN-PCSSC in participants with homozygous familial hypercholesterolemia has completed with results posted.
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CLINICAL_TRIALS trial_result · 2019-12-09Clinical Trial Update: Study of REGN1500 in Participants With Homozygous Familial Hypercholesterolemia (HoFH) [Phase 2]
Phase 2 trial of REGN1500 in Homozygous Familial Hypercholesterolemia completed with results posted.
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CLINICAL_TRIALS trial_result · 2018-05-11Clinical Trial Update: Long Term, Follow-on Study of Lomitapide in Patients With Homozygous Familial Hypercholesterolemia [Phase 3]
Phase 3 long-term follow-on study of lomitapide in patients with homozygous familial hypercholesterolemia. Results from the completed study …