HIV Infection
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CLINICAL_TRIALS trial_result · 2025-02-05Clinical Trial Update: Smoking Cessation Interventions for People Living With HIV in Nairobi, Kenya [Phase 3]
Phase 3 clinical trial in Nairobi evaluating smoking cessation interventions for people living with HIV completed, with results posted in Fe…
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CLINICAL_TRIALS research · 2025-02-05Clinical Trial Update: Use of Long-Acting Injectable Cabotegravir/Rilpivirine for the Treatment of HIV in Belgium
Belgian researchers are recruiting for a trial evaluating the long-acting injectable cabotegravir/rilpivirine for HIV treatment (Cabenuva) i…
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CLINICAL_TRIALS research · 2025-02-05Clinical Trial Update: A Study to Determine the Cartography of Virologic Reservoir Related to Antiretroviral Concentrations in HIV-1 Chronic Patients Treated by a First Line Treatment Containing bictégravir, Emtricitabine and ténofovir alafénamide [NA]
This clinical trial update describes a study in HIV-1–infected adults to map virologic reservoirs at various antiretroviral concentrations i…
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CLINICAL_TRIALS research · 2025-02-05Clinical Trial Update: Study Evaluating the Safety, in Terms of HBV Virological Control At 96 Weeks, of 2 Antiviral Treatment Relief Strategies, in Patients Co-infected with the HIV-1 and HBV Viruses [Phase 2]
Phase 2 study evaluating two antiviral treatment relief strategies for safety and HBV virological control over 96 weeks in HIV/HBV co-infect…
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CLINICAL_TRIALS trial_result · 2025-02-04Clinical Trial Update: A Study of 2 Different Regimens of Tetravalent Ad26.Mos4.HIV Prime Followed by Boost With Modified Vaccinia Ankara (MVA)-Mosaic OR Ad26.Mos4.HIV Plus a Combination of Mosaic and Clade C gp140 Protein in Human Immunodeficiency Virus (HIV) Type 1 Infected Adults on Suppressive Antiretroviral Treatment [Phase 1]
Phase 1 trial evaluating two regimens of Ad26.Mos4.HIV prime-boost followed by either MVA-Mosaic or a mosaic/Clade C gp140 protein combinati…
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CLINICAL_TRIALS research · 2025-02-04Clinical Trial Update: PrEPared to Choose (PtC) is an Implementation Study of the Delivery of Cabotegravir Long-acting, an Injectable Pre-exposure Prophylaxis (PrEP) Option for HIV Prevention. Injectable PrEP Will be Offered Alongside Oral and Vaginal Ring PrEP From Within a Real-world Context in Cape Town, South Africa.
Implementation study in Cape Town evaluates delivering cabotegravir long-acting injectable PrEP alongside oral and vaginal ring PrEP in real…
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CLINICAL_TRIALS trial_result · 2025-02-04Clinical Trial Update: Feasibility of Positive Links for Youth Care Engagement Intervention [NA]
Completed clinical trial evaluating the feasibility of Positive Links, a youth care engagement intervention for individuals with HIV infecti…
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: A Study to Investigate the Effect of Different Particle Sizes on the Single-dose Pharmacokinetics of Rilpivirine After Intramuscular Injection of a Long-acting Nanosuspension in Healthy Participants [Phase 1]
A completed Phase 1 study evaluated how different particle sizes affect the single-dose pharmacokinetics of a long-acting rilpivirine nanosu…
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EMA approval · 2025-01-31EMA Authorised: Emtricitabine/Tenofovir disoproxil Krka (emtricitabine;tenofovir disoproxil succinate) — KRKA, d.d., Novo mesto
The EMA authorised the fixed-dose combination emtricitabine/tenofovir disoproxil for HIV infections, marketed by KRKA, d.d., Novo mesto.
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CLINICAL_TRIALS trial_result · 2025-01-31Clinical Trial Update: An Open-label, Non-randomized, Single-arm Study to Investigate the Mechanism(s) by Which Nevirapine Increases Plasma HDL in HIV+ Subjects [Phase 4]
Phase 4 open-label, non-randomized single-arm trial to investigate how Nevirapine increases plasma HDL in HIV-infected subjects; the study i…
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CLINICAL_TRIALS research · 2025-01-31Clinical Trial Update: Optimizing Care Delivery to Support Reengagement in PLWH Returning to HIV Care After Treatment Lapses in Zambia
This clinical trial update describes strategies to optimize care delivery to help people living with HIV reengage in HIV care after lapses i…
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CLINICAL_TRIALS research · 2025-01-31Clinical Trial Update: Home-based Self-sampling for Cervical Cancer Prevention Education Intervention in Ghana [NA]
A not-yet-recruiting clinical trial in Ghana explores home-based self-sampling and education strategies to promote cervical cancer screening…
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CLINICAL_TRIALS research · 2025-01-31Clinical Trial Update: Antiretrovirals Combined With Antibodies for HIV-1 Cure In Africa [Phase 2]
A Phase 2 trial in Africa evaluating a combination of antiretrovirals and antibodies for HIV-1 infection is currently recruiting.
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CLINICAL_TRIALS research · 2025-01-30Clinical Trial Update: Identification of Barriers and Facilitators of Implementation of the Out-of-Hospital Administration of the Long- Acting Combination Cabotegravir+Rilpivirina. [NA]
A completed clinical trial evaluating barriers and facilitators to implementing out-of-hospital administration of the long-acting cabotegrav…
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CLINICAL_TRIALS trial_result · 2025-01-29Clinical Trial Update: Outcome at 5 Years of Early Treated HIV Infected Infants in the PEDIACAM Project
The update reports the five-year outcomes of HIV-infected infants who were treated early in the PEDIACAM trial.
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EMA approval · 2025-01-28EMA Authorised: Darunavir Krka (darunavir) — KRKA, d.d., Novo mesto
The EMA authorised Darunavir Krka for treatment of HIV infections.
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CLINICAL_TRIALS trial_result · 2025-01-28Clinical Trial Update: Zepatier in Patients with Substance Use
A clinical trial update indicates that Zepatier (elbasvir/grazoprevir) has completed a study in patients with hepatitis C who have substance…
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CLINICAL_TRIALS research · 2025-01-28Clinical Trial Update: HIV and Changes in the Gut Microbiome After Changes in Antiretroviral Therapy (ART)
This clinical trial is studying how changing antiretroviral therapy affects the gut microbiome in people with HIV.
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CLINICAL_TRIALS trial_result · 2025-01-28Clinical Trial Update: The Cedar Project: Impact of mHealth for HIV Prevention Among Young Indigenous People Who Use Illicit Drugs [NA]
Clinical trial update for The Cedar Project assessing mHealth HIV prevention among young Indigenous people who use illicit drugs. The study …
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CLINICAL_TRIALS trial_result · 2025-01-27Clinical Trial Update: Study to Evaluate the Safety and Efficacy of Teropavimab and Zinlirvimab in Combination With Lenacapavir in Virologically Suppressed Adults With HIV-1 Infection [Phase 1]
Phase 1 study assessing safety and preliminary efficacy of teropavimab and zinlirvimab with lenacapavir in virologically suppressed adults w…
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CLINICAL_TRIALS research · 2025-01-27Clinical Trial Update: SYV: A Mental Health Intervention to Improve HIV Outcomes in Tanzanian Youth [NA]
A clinical trial update notes an active, non-recruiting study evaluating a mental health intervention to improve HIV outcomes in Tanzanian y…
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CLINICAL_TRIALS trial_result · 2025-01-24Clinical Trial Update: SEARCH CAB LA Dynamic Choice HIV Prevention Study Extension [Phase 4]
The SEARCH CAB LA Dynamic Choice HIV Prevention Study Extension (Phase 4) has completed and posted results evaluating the use of cabotegravi…
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CLINICAL_TRIALS research · 2025-01-24Clinical Trial Update: Peer Delivered HIV/Syphilis Self-Testing With Assisted Partner Notification Services [Phase 2]
Phase 2 clinical trial evaluating peer-delivered HIV and syphilis self-testing with assisted partner notification; currently enrolling by in…
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CLINICAL_TRIALS research · 2025-01-23Clinical Trial Update: Chemsex Engagement and HIV Biomedical Prevention in MSM
This is a completed clinical trial update from the Chinese University of Hong Kong studying chemsex engagement and HIV biomedical prevention…
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CLINICAL_TRIALS trial_result · 2025-01-22Clinical Trial Update: A Combination Efficacy Study in Africa of Two DNA-MVA-Env Protein or DNA-Env Protein HIV-1 Vaccine Regimens With PrEP [Phase 2]
Phase 2 trial evaluating two HIV-1 vaccine regimens (DNA-MVA-Env Protein and DNA-Env Protein) with PrEP has completed in Africa.