HIV Infection
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CLINICAL_TRIALS trial_result · 2010-09-14Clinical Trial Update: Efficacy and Safety of Raltegravir (RAL) in Treatment-experienced HIV-1 Infected Adult Chinese Patients [Phase 4]
Phase 4 trial update on the efficacy and safety of raltegravir in treatment-experienced HIV-1 infected adult Chinese patients.
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CLINICAL_TRIALS trial_result · 2010-09-13Clinical Trial Update: Atazanavir Versus Lopinavir/Ritonavir (LPV/RTV) in Patients Who Have Not Had Success With Protease Inhibitor-Containing HAART Regimen(s) [Phase 3]
A Phase 3 clinical trial comparing atazanavir to lopinavir/ritonavir in HIV-infected patients who have not had success with protease inhibit…
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CLINICAL_TRIALS trial_result · 2010-09-13Clinical Trial Update: GSK1349572 Drug Interaction Study With Protease Inhibitors [Phase 1]
A Phase 1 drug interaction study evaluating dolutegravir (GSK1349572) with protease inhibitors; the study has completed.
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CLINICAL_TRIALS trial_result · 2010-09-10Clinical Trial Update: Changes in Triglyceride and Other Lipids (Levels of Fats Found in Blood) When Taking Darunavir Compared to Atazanavir in HIV-infected Patients That Have Never Received Treatment [Phase 4]
A Phase 4 trial comparing triglyceride and other lipid changes in HIV-infected treatment-naive patients taking darunavir versus atazanavir. …
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CLINICAL_TRIALS trial_result · 2010-09-02Clinical Trial Update: A Study of Patients Who Develop HIV Infection After Enrolling in HIV Vaccine Trials or HIV Vaccine Preparedness Trials
This is a completed clinical trial update from the HIV Vaccine Trials Network about patients who developed HIV infection after enrolling in …
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CLINICAL_TRIALS trial_result · 2010-08-26Clinical Trial Update: A Trial of PEHRG214 in HIV-Infected Patients [Phase 2]
A Phase 2 clinical trial of PEHRG214 in HIV-infected patients has been terminated.
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CLINICAL_TRIALS trial_result · 2010-08-25Clinical Trial Update: Pharmacokinetics of Efavirenz in HIV-1 Infected Subjects With Hepatic Impairment [Phase 1]
Phase 1 pharmacokinetic study evaluating efavirenz in HIV-1 infected adults with hepatic impairment to assess dosing considerations.
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FDA approval · 2010-08-24FDA Approved: ZIDOVUDINE — Supplemental Application (Aurobindo Pharma Limited)
The FDA approved a supplemental application for Zidovudine from Aurobindo Pharma Limited, authorizing changes related to the generic Zidovud…
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CLINICAL_TRIALS trial_result · 2010-08-19Clinical Trial Update: Safety and Efficacy of Tenofovir DF in HIV-1 Infected Adolescents Failing Their Current Antiretroviral Therapy [Phase 3]
Phase 3 trial evaluating safety and efficacy of tenofovir disoproxil fumarate in HIV-1 infected adolescents failing their current antiretrov…
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CLINICAL_TRIALS trial_result · 2010-08-19Clinical Trial Update: Evaluation of Diagnostic HIV Ag/Ab Combo Assay [Phase 3]
Phase 3 clinical evaluation of Abbott Diagnostics Division's HIV Ag/Ab Combo diagnostic assay. The study is completed and results were poste…
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CLINICAL_TRIALS trial_result · 2010-08-17Clinical Trial Update: Efficacy Study of Substitution of Darunavir/Ritonavir (DRV/r) for Dual-boosted Protease Inhibitors [Phase 4]
Phase 4 efficacy study assessing substitution of darunavir/ritonavir for other boosted protease inhibitor regimens in HIV infection. Results…
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FDA approval · 2010-08-16FDA Approved: APTIVUS — Supplemental Application (Boehringer Ingelheim Pharmaceuticals, Inc.)
The FDA approved a supplemental application for APTIVUS (tipranavir) from Boehringer Ingelheim Pharmaceuticals, Inc. The action involves cha…
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CLINICAL_TRIALS trial_result · 2010-08-16Clinical Trial Update: Raltegravir and Ezetimibe PK Study [Phase 1]
A Phase 1 pharmacokinetic study evaluated the interaction between raltegravir and ezetimibe in HIV-infected participants; the trial has comp…
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CLINICAL_TRIALS trial_result · 2010-08-16Clinical Trial Update: Raltegravir Insulin Sensitivity Study [Phase 1]
This document notes the completion of a Phase 1 study evaluating insulin sensitivity in participants treated with raltegravir for HIV infect…
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CLINICAL_TRIALS trial_result · 2010-08-16Clinical Trial Update: Atazanavir/Ritonavir and Darunavir/Ritonavir PK Tail Study [Phase 1]
Phase 1 pharmacokinetic tail study of fixed-dose combinations atazanavir/ritonavir and darunavir/ritonavir in HIV infection has completed.
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CLINICAL_TRIALS trial_result · 2010-08-16Clinical Trial Update: Double Protease Inhibitor to Darunavir Switch Study [Phase 4]
Phase 4 trial assessing switching from double protease inhibitor therapy to darunavir in HIV infection has completed.
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CLINICAL_TRIALS trial_result · 2010-08-16Clinical Trial Update: Pre-Exposure Prophylaxis Using TMC278LA [Phase 1, Phase 2]
A Phase 1/Phase 2 study evaluating the long-acting rilpivirine formulation (TMC278LA) for HIV pre-exposure prophylaxis has been terminated.
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CLINICAL_TRIALS trial_result · 2010-08-16Clinical Trial Update: Maraviroc 300 mg Twice Daily in HIV Negative Male Volunteers [Phase 1]
Phase 1 trial update reporting maraviroc 300 mg twice daily in HIV-negative male volunteers; the study status is completed.
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CLINICAL_TRIALS trial_result · 2010-08-12Clinical Trial Update: Anti-HIV Drugs for Ugandan Patients With HIV and Tuberculosis [Phase 3]
A Phase 3 clinical trial update from NIAID on anti-HIV drugs in Ugandan patients with HIV and tuberculosis, with the trial status completed.
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CLINICAL_TRIALS trial_result · 2010-08-09Clinical Trial Update: A Pilot Study of Pre-Exposure Prophylaxis (PrEP) to Evaluate Safety, Acceptability, and Adherence in At-Risk Populations in Kenya, Africa [Phase 1, Phase 2]
This completed Phase 1/2 pilot trial in Kenya evaluated the safety, acceptability, and adherence of Pre-Exposure Prophylaxis (PrEP) in at-ri…
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FDA approval · 2010-08-04FDA Approved: ZIAGEN — Supplemental Application (ViiV Healthcare Company)
The FDA approved a supplemental application for ZIAGEN (abacavir sulfate) submitted by ViiV Healthcare Company.
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CLINICAL_TRIALS trial_result · 2010-08-04Clinical Trial Update: Effectiveness Study Low-Dose Naltrexone Versus ARV's for HIV+ [Phase 2]
Phase 2 trial evaluating low-dose naltrexone against standard antiretroviral therapy in HIV-positive individuals has completed.
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CLINICAL_TRIALS trial_result · 2010-08-02Clinical Trial Update: ROCKET I - Randomized Open Label Switch for Cholesterol Elevation on Kivexa Evaluation Trial [Phase 4]
Phase 4 randomized open-label trial evaluating a switch strategy for cholesterol elevation in patients on Kivexa has completed.
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CLINICAL_TRIALS trial_result · 2010-08-02Clinical Trial Update: HIV-1 Viral Dynamics in Subjects Initiating Raltegravir Therapy
A clinical trial update describing HIV-1 viral dynamics in subjects initiating raltegravir therapy; the study (NCT00709397) is terminated.
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CLINICAL_TRIALS trial_result · 2010-07-30Clinical Trial Update: Evaluation of the Efficacy of Hydroxychloroquine in Decreasing Immune Activation in Asymptomatic HIV-infected Patients [Phase 2]
This document reports a Phase 2 clinical trial evaluating whether hydroxychloroquine can decrease immune activation in asymptomatic HIV-infe…