HIV Infection
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CLINICAL_TRIALS research · 2012-12-12Clinical Trial Update: Study on Immunopathogenesis in HIV and Hepatitis C Coinfection
A completed clinical study investigated immune-pathway mechanisms in HIV and hepatitis C coinfection, including fibrosis and inflammation. T…
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CLINICAL_TRIALS trial_result · 2012-12-11Clinical Trial Update: TMC125HIV1083 - Swallowability of Uncoated 200 mg Etravirine Tablets in HIV-1 Infected Patients [Phase 1]
Phase 1 study evaluating swallowability of uncoated 200 mg etravirine tablets in HIV-1 infected patients. The document reports on tablet acc…
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CLINICAL_TRIALS research · 2012-12-11Clinical Trial Update: Mobile Phone Text Messaging Referral [NA]
Clinical trial update for NCT01746758 from the Liverpool School of Tropical Medicine evaluating mobile phone text messaging referrals for HI…
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FDA approval · 2012-12-07FDA Approved: EDURANT — Supplemental Application (Janssen Products, LP)
FDA approved a supplemental application for EDURANT (rilpivirine hydrochloride) by Janssen Products, LP.
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CLINICAL_TRIALS trial_result · 2012-12-05Clinical Trial Update: Comparative Tolerability of Protease Inhibitors
This update reports a completed clinical trial comparing the tolerability of different HIV protease inhibitors.
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CLINICAL_TRIALS trial_result · 2012-12-05Clinical Trial Update: Partner-Specific HIV Risk Reduction Intervention for Drug-Using Adolescents [NA]
Completed clinical trial evaluating a partner-specific HIV risk reduction intervention for drug-using adolescents, sponsored by Women and In…
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CLINICAL_TRIALS withdrawal · 2012-12-05Clinical Trial Update: An Open-label Trial of the Effect of Valacyclovir on Plasma HIV-1 Levels Among HIV-1 Seropositive and HSV-1/2 Seronegative Persons [NA]
This open-label trial studied whether valacyclovir affects plasma HIV-1 levels in HIV-1 seropositive, HSV-1/2 seronegative adults. The study…
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FDA approval · 2012-11-30FDA Approved: KALETRA — Supplemental Application (AbbVie Inc.)
FDA approved a supplemental application for Kaletra (lopinavir/ritonavir) submitted by AbbVie Inc.
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CLINICAL_TRIALS trial_result · 2012-11-27Clinical Trial Update: Contingency Management for Methamphetamine Abstinence and HIV Post-Exposure Prophylaxis in Men Who Have Sex With Men [Phase 2]
Phase 2 clinical trial update on contingency management to promote methamphetamine abstinence and HIV post-exposure prophylaxis among men wh…
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CLINICAL_TRIALS trial_result · 2012-11-27Clinical Trial Update: An Evaluation of a Rapid Test for HIV [Phase 3]
Phase 3 clinical trial evaluating a rapid HIV diagnostic test has completed.
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CLINICAL_TRIALS research · 2012-11-27Clinical Trial Update: Maraviroc (CCR5) Antagonism to Decrease the Incidence of the Immune Reconstitution Inflammatory Syndrome in HIV-Infected Patients [NA]
Clinical trial update evaluating maraviroc (CCR5 antagonist) to reduce the incidence of Immune Reconstitution Inflammatory Syndrome in HIV-i…
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CLINICAL_TRIALS trial_result · 2012-11-21Clinical Trial Update: Pharmacokinetic Interactions Between Buprenorphine and Kaletra (Lopinavir/Ritonavir) [NA]
A pharmacokinetic study evaluating interactions between buprenorphine and Kaletra (lopinavir/ritonavir) in HIV infection; results were poste…
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CLINICAL_TRIALS trial_result · 2012-11-21Clinical Trial Update: Buprenorphine/Raltegravir Pharmacokinetic Interaction Study [NA]
A pharmacokinetic interaction study evaluated the co-administration of buprenorphine and raltegravir in HIV-infected individuals, with resul…
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CLINICAL_TRIALS trial_result · 2012-11-21Clinical Trial Update: Pharmacokinetic Interactions Between Buprenorphine and Tipranavir/Ritonavir [NA]
A completed clinical trial evaluating pharmacokinetic interactions between buprenorphine and tipranavir/ritonavir in HIV infection.
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FDA approval · 2012-11-20FDA Approved: NORVIR — Supplemental Application (AbbVie Inc.)
The FDA approved AbbVie’s supplemental application for Norvir (ritonavir). The approval updates the product’s labeling and/or approved use f…
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CLINICAL_TRIALS trial_result · 2012-11-20Clinical Trial Update: TMC278-TiDP15-C158 - A Study to Examine the Safety, Tolerability and Pharmacokinetics of a Single Dose or Three Successive Doses of Intramuscularly (IM) Injected Long Acting Formulation of TMC278 [Phase 1]
A Phase 1 study assessing the safety, tolerability, and pharmacokinetics of a single-dose or multi-dose IM long-acting formulation of TMC278…
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CLINICAL_TRIALS trial_result · 2012-11-19Clinical Trial Update: A Study of Anti-HIV Monoclonal Antibody KD-247 [Phase 1]
A Phase 1 clinical trial evaluating KD-247, an anti-HIV monoclonal antibody, has completed.
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FDA approval · 2012-11-09FDA Approved: PREZISTA — Supplemental Application (Janssen Products LP)
FDA approved a supplemental application for Prezista (darunavir) submitted by Janssen Products LP, resulting in an updated labeling for the …
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CLINICAL_TRIALS trial_result · 2012-11-09Clinical Trial Update: Study of PENNVAX™-B (Gag, Pol, Env) + Electroporation in HIV-1 Infected Adult Participants [Phase 1]
This is a completed Phase 1 clinical trial evaluating PENNVAX-B (Gag, Pol, Env) delivered by electroporation in adults infected with HIV-1.
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CLINICAL_TRIALS withdrawal · 2012-11-08Clinical Trial Update: A Multicentre Trial of Second-line Antiretroviral Treatment Strategies in African Adults Using Atazanavir or Lopinavir/Ritonavir [Phase 3]
A multicenter Phase 3 trial evaluating second-line antiretroviral regimens with atazanavir or lopinavir/ritonavir in African adults has been…
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CLINICAL_TRIALS trial_result · 2012-11-07Clinical Trial Update: A Study to Examine the Human Papillomavirus Types Exposure in Women From Southern Africa and Brasil
A completed clinical study examining exposure to human papillomavirus types in women from Southern Africa and Brazil, including participants…
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CLINICAL_TRIALS trial_result · 2012-11-02Clinical Trial Update: Immune Therapies and Anti-HIV Therapy Withdrawal in Controlling Viral Load [Phase 2]
An update on a Phase 2 trial evaluating immune therapies and withdrawal of anti-HIV therapy to control viral load in HIV infection.
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CLINICAL_TRIALS trial_result · 2012-11-01Clinical Trial Update: Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS-Related Primary Central Nervous System Lymphoma [Phase 2]
This update reports results from a Phase II trial evaluating sequential chemotherapy followed by radiotherapy for AIDS-related primary centr…
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CLINICAL_TRIALS trial_result · 2012-11-01Clinical Trial Update: HPMPC (Cidofovir) Peripheral CMV Retinitis Trial Protocol [NA]
This entry notes completion of a clinical trial protocol evaluating cidofovir (HPMPC) for peripheral cytomegalovirus retinitis in HIV-infect…
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CLINICAL_TRIALS trial_result · 2012-11-01Clinical Trial Update: A Phase I Study to Evaluate the Safety and Toxicity of the Combination of Zidovudine and 2',3'-Dideoxyinosine (Didanosine) in Children With HIV Infection [Phase 1]
This is a Phase I safety and toxicity study of the combination of Zidovudine and Didanosine in children with HIV infection. The trial status…