HIV Infection
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CLINICAL_TRIALS trial_result · 2018-04-05Clinical Trial Update: Gene Expression in HIV and Tuberculosis Co-infection
The document reports a completed clinical trial update from NIAID examining gene expression in HIV and tuberculosis co-infection.
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CLINICAL_TRIALS trial_result · 2018-04-05Clinical Trial Update: Reducing Proviral HIV DNA With Interferon-a [Phase 2]
A Phase 2 clinical trial from The Wistar Institute is evaluating interferon-alpha to reduce proviral HIV DNA in people with HIV infection/AI…
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CLINICAL_TRIALS trial_result · 2018-04-05Clinical Trial Update: Multiplex Microarray Chip-Based Diagnosis of Respiratory Infections
An NIAID-sponsored trial evaluated a multiplex microarray chip for diagnosing respiratory infections in people with HIV; the study has been …
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CLINICAL_TRIALS research · 2018-04-05Clinical Trial Update: Collection of Tissue Specimens in Mali, West Africa, for HIV and Tuberculosis Research
A terminated Mali tissue-sample collection study for HIV and tuberculosis sponsored by NIAID is noted in this clinical trial update.
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CLINICAL_TRIALS research · 2018-04-03Clinical Trial Update: Understanding Medication Adherence Among HIV Patients [NA]
A completed clinical trial investigating patient commitment preferences for medication adherence among people with HIV.
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CLINICAL_TRIALS trial_result · 2018-03-30Clinical Trial Update: A Prospective, Observational Study of Pregnancy Outcomes Among Women Exposed to Truvada for PrEP Indication
This update summarizes the results of a prospective observational study on pregnancy outcomes in women exposed to Truvada for HIV pre-exposu…
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CLINICAL_TRIALS trial_result · 2018-03-30Clinical Trial Update: Sofosbuvir-Containing Regimens Without Interferon For Treatment of Acute Hepatitis C Virus (HCV) Infection [Phase 1]
Phase 1 trial update evaluating sofosbuvir-containing regimens without interferon for acute hepatitis C infection, including participants wi…
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CLINICAL_TRIALS trial_result · 2018-03-30Clinical Trial Update: Dolutegravir Plus Lamivudine Dual Therapy in Treatment Naïve HIV-1 Patients [Phase 2]
Phase 2 results for dolutegravir plus lamivudine dual therapy in treatment-naïve HIV-1 infection were posted after the trial completed. The …
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CLINICAL_TRIALS trial_result · 2018-03-30Clinical Trial Update: HIV Prevention and Trauma Treatment for Men Who Have Sex With Men With Childhood Sexual Abuse Histories [NA]
A Massachusetts General Hospital study update reports on a completed clinical trial evaluating HIV prevention strategies and trauma-focused …
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CLINICAL_TRIALS trial_result · 2018-03-29Clinical Trial Update: Functionality of Male Condoms With a Silicone Elastomer Vaginal RIng [Phase 1]
Phase 1 clinical trial evaluating the functionality of male condoms used with a silicone elastomer vaginal ring; the study targeting HIV has…
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CLINICAL_TRIALS trial_result · 2018-03-27Clinical Trial Update: Safety and Efficacy of Bictegravir + Emtricitabine/Tenofovir Alafenamide Versus Dolutegravir + Emtricitabine/Tenofovir Alafenamide in HIV-1 Infected, Antiretroviral Treatment-Naive Adults [Phase 2]
Phase 2 trial comparing Bictegravir + Emtricitabine/Tenofovir Alafenamide to Dolutegravir + Emtricitabine/Tenofovir Alafenamide in antiretro…
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CLINICAL_TRIALS research · 2018-03-27Clinical Trial Update: A Prospective, Observational, Drug Utilization Study of Subjects Taking Truvada for Pre-exposure Prophylaxis in the USA
A completed prospective observational study evaluating the use of Truvada for HIV pre-exposure prophylaxis in the United States.
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CLINICAL_TRIALS research · 2018-03-27Clinical Trial Update: Gut Microbiota and Immune Recovery
This entry provides an update on a clinical trial examining gut microbiota and immune recovery in HIV-1 infection. The study is sponsored by…
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CLINICAL_TRIALS trial_result · 2018-03-26Clinical Trial Update: Safety/Effectiveness of Oral Chemokine Coreceptor 5 (CCR5) Antagonist INCB009471 in R5-tropic HIV Infected Patients [Phase 2]
A Phase 2 trial evaluating the safety and effectiveness of the oral CCR5 antagonist INCB009471 in patients with R5-tropic HIV infection has …
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FDA approval · 2018-03-22FDA Approved: SYMFI — Original Application (Viatris Specialty LLC)
The FDA approved Symfi, a fixed-dose combination tablet of efavirenz, lamivudine, and tenofovir disoproxil fumarate, under NDA 022142 by Via…
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CLINICAL_TRIALS trial_result · 2018-03-20Clinical Trial Update: Observational Cohort of HIV Infected Adults and Children in the PHPT Network Hospitals in Thailand
This is an update on a completed observational cohort study of HIV-infected adults and children conducted across PHPT Network Hospitals in T…
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CLINICAL_TRIALS trial_result · 2018-03-19Clinical Trial Update: Clinical Trial on the Effects of Progestin-based Contraception in the Genital Tract of HIV-infected and Uninfected Women [Phase 4]
A Phase 4 trial evaluated the effects of progestin-based contraception on the genital tract in HIV-infected and uninfected women, and the st…
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CLINICAL_TRIALS trial_result · 2018-03-19Clinical Trial Update: Depression and ART Adherence in HIV+ Latinos [NA]
This completed clinical trial studied the relationship between depressive symptoms and adherence to antiretroviral therapy in HIV-positive L…
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CLINICAL_TRIALS trial_result · 2018-03-15Clinical Trial Update: Therapeutic HPV-16 Vaccination for the Treatment of Anal Dysplasia [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating a therapeutic HPV-16 vaccine for anal intraepithelial neoplasia in people with HIV has completed.
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FDA approval · 2018-03-14FDA Approved: ABACAVIR — Original Application (Rising Pharma Holdings, Inc.)
FDA approved the original application for abacavir sulfate (abacavir) as a generic drug. Rising Pharma Holdings, Inc. is the manufacturer.
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CLINICAL_TRIALS trial_result · 2018-03-13Clinical Trial Update: Enhancement by Poly-ICLC During HIV-1 Infection [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating Poly-ICLC as an enhancer during HIV-1 infection completed, with results posted in March 2018.
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CLINICAL_TRIALS research · 2018-03-13Clinical Trial Update: An Expanded Access Protocol for a Single Subject Who Has Completed 24-Weeks of Treatment in PR0140_CD02 Study
Expanded access protocol update for a single HIV patient who completed 24 weeks of treatment in CytoDyn's PR0140_CD02 study.
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CLINICAL_TRIALS trial_result · 2018-03-13Clinical Trial Update: Functional Cure Study of HIV-infected Patients [NA]
This entry notes the completion of a clinical trial investigating functional cure strategies in HIV infection. The sponsor is Kaohsiung Medi…
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CLINICAL_TRIALS trial_result · 2018-03-12Clinical Trial Update: Clinical Trial to Evaluate Drug-drug Interactions Between Darunavir/Cobicistat and Etravirine in Hiv- Infected Patients [Phase 1]
This Phase 1 study evaluated potential drug-drug interactions between darunavir/cobicistat and etravirine in HIV-1 infected patients; the tr…
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CLINICAL_TRIALS trial_result · 2018-03-09Clinical Trial Update: Testosterone and Physical Function in HIV+ Men [Phase 2]
This is a Phase 2 clinical trial evaluating testosterone to improve physical function in HIV-positive men. The study status is completed.