HIV Infection
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CLINICAL_TRIALS trial_result · 2023-02-14Clinical Trial Update: Dual bNAb Treatment in Children [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating a dual broadly neutralizing antibody (bNAb) treatment for HIV infection in children has completed enro…
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CLINICAL_TRIALS trial_result · 2023-02-08Clinical Trial Update: Pivotal Phase 2b/3 ALVAC/Bivalent gp120/MF59 HIV Vaccine Prevention Safety and Efficacy Study in South Africa [Phase 2, Phase 3]
Pivotal Phase 2b/3 trial in South Africa evaluates the safety and efficacy of an ALVAC-based HIV vaccine with bivalent gp120 and MF59 adjuva…
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CLINICAL_TRIALS trial_result · 2023-02-08Clinical Trial Update: ADVANCE Study of DTG + TAF + FTC vs DTG + TDF + FTC and EFV + TDF+FTC in First-line Antiretroviral Therapy [Phase 3]
Phase 3 trial update comparing DTG + TAF + FTC vs DTG + TDF + FTC and EFV + TDF + FTC in first-line antiretroviral therapy for HIV-1 infecti…
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CLINICAL_TRIALS trial_result · 2023-02-08Clinical Trial Update: Effects of Biktarvy on CFR in Stable HIV Patients [Phase 3]
Phase 3 trial update on Biktarvy showing effects on CFR in stable HIV patients; results posted.
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CLINICAL_TRIALS trial_result · 2023-02-03Clinical Trial Update: Reaching Adolescent Girls and Young Women Through Girl-Friendly Drug Vendors [NA]
A completed clinical trial focusing on reaching adolescent girls and young women through girl-friendly drug vendors, with results posted in …
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CLINICAL_TRIALS trial_result · 2023-02-02Clinical Trial Update: Safety Tolerability DDI Short Course Treatment of LTBI Infection With High-dose Rifapentine and Isoniazid or Standard Isoniazid Preventive Therapy in HIV+ Patients (DOLPHIN & DOLPHIN TOO) [Phase 1, Phase 2]
Phase 1/2 trial update on safety and tolerability of high-dose rifapentine with isoniazid for latent TB infection in HIV+ patients, compared…
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CLINICAL_TRIALS trial_result · 2023-02-01Clinical Trial Update: Evaluating the Safety and Immunogenicity of EnvSeq-1 and CH505 M5 gp120 Envs Adjuvanted With GLA-SE in Healthy, HIV-Uninfected Adults [Phase 1]
Phase 1 trial assessing the safety and immunogenicity of EnvSeq-1 and CH505 M5 gp120 Env immunogens with the GLA-SE adjuvant in healthy, HIV…
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CLINICAL_TRIALS trial_result · 2023-01-20Clinical Trial Update: Rectal Microbicide Acceptability, Tolerability and Adherence [NA]
Completed clinical trial assessing acceptability, tolerability, and adherence of a rectal microbicide for HIV prevention; results posted in …
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CLINICAL_TRIALS trial_result · 2023-01-19Clinical Trial Update: Bone Health in Aging HIV Infected Women [Phase 4]
This Phase 4 clinical trial update reports completion and results posting of a study on bone health in aging women with HIV, focusing on ost…
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CLINICAL_TRIALS trial_result · 2023-01-11Clinical Trial Update: OPEN Study: Pain Management Treatment Needs Interviews
A completed clinical trial update reporting interviews for pain management treatment needs in HIV-associated peripheral neuropathy.
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CLINICAL_TRIALS trial_result · 2023-01-10Clinical Trial Update: Cabozantinib S-Malate in Treating Patients With Advanced Solid Tumors and Human Immunodeficiency Virus [Phase 1]
Phase 1 trial evaluating cabozantinib malate in patients with advanced solid tumors and HIV infection has completed with results posted.
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CLINICAL_TRIALS trial_result · 2023-01-09Clinical Trial Update: An Integrated Strategy to Support Antiretroviral Therapy and Pre-exposure Prophylaxis Adherence for HIV Prevention in Pregnant and Breastfeeding Women [NA]
Clinical trial update on strategies to support antiretroviral therapy and pre-exposure prophylaxis adherence for HIV prevention in pregnant …
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CLINICAL_TRIALS trial_result · 2023-01-06Clinical Trial Update: Optimizing Malaria Treatment for HIV-Malaria Co-infected Individuals [Phase 4]
Phase 4 trial update focused on optimizing malaria treatment in individuals co-infected with HIV.
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CLINICAL_TRIALS trial_result · 2023-01-05Clinical Trial Update: Testing the Safety and Efficacy of Commercial Drug Biktarvy in Subjects Known to Have the 184 Resistance Mutation to a Component in Biktarvy [Phase 4]
A Phase 4 clinical trial assessing the safety and efficacy of Biktarvy in subjects with the 184 resistance mutation; the study has been term…
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CLINICAL_TRIALS trial_result · 2022-12-27Clinical Trial Update: Optimizing Viral Load Suppression in Kenyan Children on Antiretroviral Therapy [NA]
A completed clinical trial evaluating strategies to optimize viral load suppression in Kenyan children on antiretroviral therapy.
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CLINICAL_TRIALS trial_result · 2022-12-27Clinical Trial Update: Building on Needle Exchange to Optimize Prevention & Treatment [NA]
Johns Hopkins-led trial on needle-exchange programs to optimize prevention and treatment has completed with results posted in December 2022.
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CLINICAL_TRIALS trial_result · 2022-12-23Clinical Trial Update: Program Refinements to Optimize Model Impact and Scalability Based on Evidence [NA]
This clinical trial update describes refinements to a program that aims to optimize model impact and scalability, with results posted after …
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CLINICAL_TRIALS trial_result · 2022-12-23Clinical Trial Update: Digital Health Feedback System for Longitudinal Measurement of Medication Adherence During Anti-Retroviral (ARV)Therapy [Phase 4]
Phase 4 clinical trial update evaluating a digital health feedback system to longitudinally measure medication adherence during antiretrovir…
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CLINICAL_TRIALS trial_result · 2022-12-22Clinical Trial Update: Strategies to Improve the HIV Care Continuum Among Key Populations in India [NA]
This is a completed clinical trial update from Johns Hopkins University evaluating strategies to improve the HIV care continuum among key po…
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CLINICAL_TRIALS trial_result · 2022-12-20Clinical Trial Update: Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) in HIV-1 Infected Patients With Active Illicit Substance usE [Phase 4]
Phase 4 clinical trial assessing Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) in HIV-1-infected patients with active illicit su…
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CLINICAL_TRIALS trial_result · 2022-12-19Clinical Trial Update: Study to Evaluate the Safety and Efficacy of Lenacapavir (GS-6207) in Combination With Other Antiretroviral Agents in People Living With HIV [Phase 2]
Phase 2 clinical trial evaluating lenacapavir (GS-6207) in combination with other antiretroviral agents for people living with HIV has compl…
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CLINICAL_TRIALS trial_result · 2022-12-15Clinical Trial Update: Effect of Dolutegravir Intensification on HIV-1 Reservoirs [Phase 2]
Phase 2 trial evaluating the effect of dolutegravir intensification on HIV-1 reservoirs in adults with HIV-1 infection; study completed.
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CLINICAL_TRIALS trial_result · 2022-12-14Clinical Trial Update: B/F/TAF vs Atripla Double-Blind Switch Study in HIV-1 Infected Adults [Phase 4]
Phase 4 double-blind switch study comparing B/F/TAF to Atripla in HIV-1 infected adults; terminated with posted results in 2022.
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CLINICAL_TRIALS trial_result · 2022-12-02Clinical Trial Update: Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions [Phase 3]
Phase 3 clinical trial update on treatment to prevent anal cancer in people with HIV and anal high-grade intraepithelial lesions; results ha…
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CLINICAL_TRIALS trial_result · 2022-11-09Clinical Trial Update: HIV Testing at Family Planning Clinics in Mombasa County, Kenya [NA]
Clinical trial updating HIV testing practices at family planning clinics in Mombasa County, Kenya; completed with results posted in 2022.