High-risk Myelodysplastic Syndrome
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Liposomal Cytarabine and Daunorubicin (CPX-351) and Quizartinib for the Treatment of Acute Myeloid Leukemia and High Risk Myelodysplastic Syndrome [Phase 1, Phase 2]
A phase 1/2 clinical trial is evaluating the combination of CPX-351 (liposomal cytarabine and daunorubicin) with Quizartinib for acute myelo…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Creation of a Biocollection of Patients With Acute Myeloid Leukemia (AML) or Lymphoid Leukemia (ALL) or High-risk Myelodysplastic Syndrome (MDS) Monitored at the Nantes University Hospital
This clinical trial update describes the creation of a biocollection of patients with acute myeloid leukemia, acute lymphoblastic leukemia, …
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: DEC-205/NY-ESO-1 Fusion Protein CDX-1401, Poly ICLC, Decitabine, and Nivolumab in Treating Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia [Phase 1]
Phase 1 trial evaluating the safety of a multi-agent regimen (CDX-1401, Poly ICLC, Decitabine, and Nivolumab) in patients with myelodysplast…
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CLINICAL_TRIALS trial_result · 2026-02-20Clinical Trial Update: Liposome-encapsulated Daunorubicin-Cytarabine and Gemtuzumab Ozogamicin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) or High Risk Myelodysplastic Syndrome [Phase 2]
Phase 2 trial evaluating liposome-encapsulated daunorubicin-cytarabine (CPX-351) in combination with gemtuzumab ozogamicin for relapsed or r…
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CLINICAL_TRIALS trial_result · 2026-02-17Clinical Trial Update: Azacitidine and Enasidenib in Treating Patients With IDH2-Mutant Myelodysplastic Syndrome [Phase 2]
This Phase 2 clinical trial investigates the combination of azacitidine and enasidenib for IDH2-mutant myelodysplastic syndrome and is curre…
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Hu8F4 in Treating Patients With Advanced Hematologic Malignancies [Phase 1]
Hu8F4 is being studied in a Phase 1 trial for multiple advanced hematologic malignancies; the study is currently active but not recruiting.
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Cladribine, Idarubicin, Cytarabine, and Quizartinib in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome [Phase 1, Phase 2]
A phase 1/2 clinical trial at MD Anderson is evaluating a quadruplet regimen of cladribine, idarubicin, cytarabine, and quizartinib for newl…
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CLINICAL_TRIALS withdrawal · 2025-10-10Clinical Trial Update: HDM201 in Combination With MBG453 or Venetoclax in Patients With Acute Myeloid Leukemia (AML) or High-risk Myelodysplastic Syndrome (MDS) [Phase 1]
A Phase 1 trial investigating HDM201 in combination with MBG453 or venetoclax in patients with acute myeloid leukemia or high-risk myelodysp…
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CLINICAL_TRIALS other · 2025-09-24Clinical Trial Update: RVU120 Rollover Study [Phase 2]
A Phase 2 rollover study of RVU120 in advanced solid tumors, acute myeloid leukemia, and high-risk myelodysplastic syndrome is not yet recru…
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CLINICAL_TRIALS trial_result · 2025-05-08Clinical Trial Update: Safety and Efficacy of RVU120 for Treatment of Relapsed/Refractory AML [Phase 2]
Clinical trial update on RVU120 for relapsed/refractory acute myeloid leukemia in a Phase 2 study. The trial is currently active but not rec…
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CLINICAL_TRIALS research · 2024-05-29Clinical Trial Update: The Patient Cohort of the National Center for Precision Medicine in Leukemia
This clinical trial update describes the patient cohort for the National Center for Precision Medicine in Leukemia and notes that patient re…
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CLINICAL_TRIALS trial_result · 2023-11-07Clinical Trial Update: Donor Natural Killer Cells and Donor Stem Cell Transplant in Treating Patients With High Risk Myeloid Malignancies [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating donor natural killer cells and donor stem cell transplant in high-risk myeloid malignancies; completed w…
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CLINICAL_TRIALS trial_result · 2023-09-21Clinical Trial Update: Daratumumab in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome [Phase 2]
Phase 2 trial evaluating daratumumab in relapsed or high-risk myeloid malignancies (high-risk myelodysplastic syndrome and recurrent/refract…
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CLINICAL_TRIALS trial_result · 2023-05-10Clinical Trial Update: A Trial of Treatments to Assess the Effects on Outcome of Adults With AML and MDS Undergoing Allogeneic SCT [Phase 2, Phase 3]
A Phase 2/3 clinical trial evaluating treatments to improve outcomes for adults with acute myeloid leukemia and high-risk myelodysplastic sy…
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CLINICAL_TRIALS trial_result · 2021-12-21Clinical Trial Update: Evaluating the Efficacy and Safety of Bemcentinib in Patients With Myelodysplastic Syndromes [Phase 2]
Phase 2 clinical trial evaluating bemcentinib for myelodysplastic syndromes and related conditions has completed.
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CLINICAL_TRIALS trial_result · 2021-05-05Clinical Trial Update: Randomised Study of Azacitidine Versus Azacitidine With Vorinostat in Patients With AML or High Risk MDS [Phase 2]
Phase 2 randomized trial comparing azacitidine alone versus azacitidine with vorinostat in patients with acute myeloid leukemia or high-risk…
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CLINICAL_TRIALS trial_result · 2018-05-30Clinical Trial Update: Omacetaxine and Low Dose Cytarabine in Older Patients With Acute Myelogenous Leukemia (AML) and High-Risk Myelodysplastic Syndrome (MDS) [Phase 2]
Phase 2 trial of omacetaxine with low-dose cytarabine in older patients with acute myeloid leukemia and high-risk myelodysplastic syndrome h…
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CLINICAL_TRIALS trial_result · 2015-05-07Clinical Trial Update: Study of Hypoxia-Activated Prodrug TH-302 to Treat Advanced Leukemias [Phase 1]
Phase 1 study of TH-302 (evofosfamide), a hypoxia-activated prodrug, in patients with advanced leukemias has been completed, with evaluation…
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CLINICAL_TRIALS research · 2014-06-11Clinical Trial Update: A Trial to Establish the Feasibility of Combining Either the Tyrosine Kinase Inhibitor AC220,CXCR4 Inhibitor Plerixafor or HSP90 Inhibitor Ganetespib With Chemotherapy in Older Patients With Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome. [Phase 1, Phase 2]
This update notes the completion of a Phase 1/2 clinical trial evaluating the feasibility of combining three agents (Quizartinib, Plerixafor…
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CLINICAL_TRIALS trial_result · 2013-09-09Clinical Trial Update: A Phase 1 Trial of TST of PD 0332991 Followed by Cytarabine and Mitoxantrone for Adults With Relapsed and Refractory Acute Leukemias and High-Risk Myelodysplasia [Phase 1]
A Phase 1 trial of PD-0332991 (palbociclib) followed by cytarabine and mitoxantrone in adults with relapsed or refractory acute leukemia and…