High-grade Serous Ovarian Cancer
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CLINICAL_TRIALS trial_result · 2026-06-04Clinical Trial Results: Alpelisib Plus Olaparib in Platinum-resistant/Refractory, High-grade Serous Ovarian Cancer, With no Germline BRCA Mutation Detected [Phase 3]
Phase 3 trial evaluating alpelisib plus olaparib in platinum-resistant/refractory high-grade serous ovarian cancer without germline BRCA mut…
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CLINICAL_TRIALS trial_result · 2026-04-14Clinical Trial Update: Elements of Adaptive Immunity in Epithelial Ovarian Cancer
A completed clinical trial update examining elements of adaptive immunity in epithelial ovarian cancer, specifically the high-grade serous s…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Combination ATR and PARP Inhibitor (CAPRI) Trial With AZD6738 and Olaparib in Recurrent Ovarian Cancer [Phase 2]
The update notes the completion of the Phase 2 CAPRI trial evaluating the combination of AZD6738 (ceralasertib) and olaparib in recurrent hi…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Upfront Systematic Tumour BRCA Testing in Patients With High Grade Serous or Endometrioid Ovarian, Fallopian Tube or Primary Peritoneal Cancer (HGSEC): The t-BRCA Study
This clinical trial update reports the completed status of the t-BRCA study evaluating upfront BRCA testing in patients with high-grade sero…
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CLINICAL_TRIALS trial_result · 2026-04-09Clinical Trial Update: Safety, PK and Efficacy of AI-061 in Advanced Solid Tumors [Phase 1]
Phase 1 update reporting safety, pharmacokinetics, and preliminary efficacy data for AI-061 in advanced solid tumors across multiple indicat…
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: Alpelisib Plus Olaparib in Platinum-resistant/Refractory, High-grade Serous Ovarian Cancer, With no Germline BRCA Mutation Detected [Phase 3]
A Phase 3 trial of alpelisib plus olaparib for platinum-resistant/refractory high-grade serous ovarian cancer without germline BRCA mutation…
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: ASTRA Study: Circulating Tumor Cells in Blood of Patients With High-Grade Serous Ovarian Cancer [NA]
The ASTRA study, which investigates circulating tumor cells in the blood of patients with high-grade serous ovarian cancer, has completed.
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CLINICAL_TRIALS trial_result · 2026-01-23Clinical Trial Update: Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene Amplifications [Phase 1]
A Phase 1 clinical trial update describes evaluation of BBI-355 (CHK1 inhibitor) in combination with BBI-825 (RNR inhibitor) for tumors with…
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CLINICAL_TRIALS trial_result · 2026-01-23Clinical Trial Update: Exploration of DNA Methylation as a Marker for Early Detection of High Grade Serous Epithelial Ovarian Cancer
A Baylor Research Institute-led clinical trial evaluating DNA methylation as an early-detection marker for high-grade serous ovarian cancer …
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CLINICAL_TRIALS trial_result · 2025-12-17Clinical Trial Update: A Study of Carboplatin and Paclitaxel Chemotherapy With Nivolumab With or Without Ipilimumab in Patients With Ovarian Cancer [Phase 1]
Phase 1 study evaluating carboplatin and paclitaxel chemotherapy with nivolumab, with or without ipilimumab, in ovarian cancer including hig…
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CLINICAL_TRIALS trial_result · 2025-11-04Clinical Trial Update: A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer [Phase 1, Phase 2]
Phase I/II study evaluating VLS-1488 in adults with advanced cancer; the trial is currently recruiting across multiple solid-tumor indicatio…
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CLINICAL_TRIALS trial_result · 2025-07-03Clinical Trial Update: A Study of MORAb-202 Versus Investigator's Choice Chemotherapy in Female Participants With Platinum-resistant High-grade Serous (HGS) Ovarian, Primary Peritoneal, or Fallopian Tube Cancer [Phase 2]
Phase 2 trial comparing MORAb-202 to investigator's choice chemotherapy in women with platinum-resistant high-grade serous ovarian cancer an…
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CLINICAL_TRIALS trial_result · 2025-05-22Clinical Trial Update: NIRAPK : Study of the Relationship(s) Between Clinical, Biological and Pharmacokinetic Metrics and Toxicities When Niraparib is Used as Maintenance Treatment for Ovarian Cancer Patients. [Phase 4]
A Phase 4 study investigating relationships between clinical, biological, and pharmacokinetic metrics and toxicities in ovarian cancer patie…
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CLINICAL_TRIALS trial_result · 2025-02-17Clinical Trial Update: A Study of KB-0742 in Participants With Relapsed or Refractory Solid Tumors Including Platinum Resistant High Grade Serous Ovarian Cancer (HGSOC) [Phase 1, Phase 2]
A clinical trial update indicates the Phase 1/2 study of KB-0742 in relapsed or refractory solid tumors, including platinum-resistant high-g…
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CLINICAL_TRIALS trial_result · 2025-01-23Clinical Trial Update: Prediction of Platinum Resistance and Prognosis of High-grade Serous Ovarian Cancer
This completed clinical trial investigates predictors of platinum resistance and prognosis in high-grade serous ovarian cancer to improve tr…
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CLINICAL_TRIALS trial_result · 2024-12-17Clinical Trial Update: A CR-UK Phase I Trial of LY3143921 [Phase 1]
Phase I trial update for LY3143921 sponsored by Cancer Research UK; the study is Active Not Recruiting and explores multiple cancer indicati…
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CLINICAL_TRIALS trial_result · 2024-11-18Clinical Trial Update: Combination of Olaparib and Navitoclax in Women with HGSC and TNBC [Phase 1]
A Phase 1 clinical trial evaluating the combination of olaparib and navitoclax in women with high-grade serous ovarian cancer and triple-neg…
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CLINICAL_TRIALS trial_result · 2024-09-05Clinical Trial Update: "Re-Stimulated" TILs and IL-2 Therapy for Platinum Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer [Phase 1]
Phase 1 clinical trial evaluating re-stimulated tumor-infiltrating lymphocytes (TILs) with interleukin-2 for platinum-resistant recurrent ca…
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CLINICAL_TRIALS trial_result · 2023-10-26Clinical Trial Update: Upifitamab Rilsodotin Maintenance in Platinum-Sensitive Recurrent Ovarian Cancer (UP-NEXT) [Phase 3]
A Phase 3 trial of Upifitamab Rilsodotin (Upifitamab Rilsodotin) in maintenance therapy for platinum-sensitive recurrent ovarian cancer has …
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CLINICAL_TRIALS trial_result · 2022-09-21Clinical Trial Update: p53 Suppressor Activation in Recurrent High Grade Serous Ovarian Cancer, a Phase Ib/II Study of Systemic Carboplatin Combination Chemotherapy With or Without APR-246 [Phase 1, Phase 2]
Phase Ib/II trial evaluating carboplatin with or without APR-246 (eprenetapopt) for platinum-sensitive recurrent high-grade serous ovarian c…
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CLINICAL_TRIALS trial_result · 2022-07-21Clinical Trial Update: p53 Activation in Platinum-Resistant High Grade Serous Ovarian Cancer, a Study of PLD With APR-246 [Phase 2]
Phase 2 study evaluating pegylated liposomal doxorubicin with APR-246 in platinum-resistant high-grade serous ovarian cancer has completed, …
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CLINICAL_TRIALS trial_result · 2020-02-07Clinical Trial Update: NUVOLA TRIAL Open-label Multicentre Study [Phase 2]
A Phase 2 open-label multicentre trial called NUVOLA in high-grade serous ovarian cancer is described, with Phase 2 status and unknown ongoi…
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CLINICAL_TRIALS trial_result · 2017-11-21Clinical Trial Update: A Study to Evaluate the Safety, Pharmacokinetics and Oral Bio Availability of Veliparib in Subjects With Solid Tumors [Phase 1]
This clinical trial update reports Phase 1 results on veliparib, evaluating safety, pharmacokinetics, and oral bioavailability in subjects w…