High-grade Serous Ovarian Cancer
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: CtDNA as a Novel Biomarker of Treatment Efficacy in Patients With Ovarian Cancer
An ongoing clinical trial is evaluating circulating tumor DNA as a biomarker of treatment efficacy in patients with high-grade serous ovaria…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Testing the Addition of Abemaciclib to Olaparib for Women With Recurrent Ovarian Cancer [Phase 1]
Phase 1 trial evaluating adding abemaciclib to olaparib in women with recurrent ovarian cancer, including high-grade serous and platinum-res…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial of GTAEXS617 in adults with advanced solid tumors is currently recruiting. The study encompasses head and neck sq…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Study of Azenosertib (ZN-c3) Versus Investigator's Choice Chemotherapy in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers Positive for Cyclin E1 Protein Expression [Phase 3]
Phase 3 trial to compare Azenosertib (ZN-c3) against investigator's choice chemotherapy in platinum-resistant high-grade serous ovarian, pri…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer [Phase 2]
Phase 2 clinical trial evaluating Azenosertib (ZN-c3) in platinum-resistant high-grade serous ovarian cancer and related fallopian tube or p…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan [Phase 1]
Phase 1 trial evaluating the safety, adverse events, and pharmacokinetics of Azirkitug alone or in combination with Budigalimab, Bevacizumab…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors [Phase 1, Phase 2]
First-in-human dose-escalation and expansion trial of AZD8421 (alone or in combination) in selected advanced solid tumors, including ER+ HER…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001) [Phase 1, Phase 2]
Genmab is conducting a Phase 1/2 clinical trial of Rinatabart Sesutecan for multiple advanced solid tumors; recruitment is ongoing.
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types [Phase 1]
IDEAYA Biosciences is conducting a Phase 1 study of IDE034 in adults with multiple locally advanced or metastatic solid tumors; the trial is…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076) [Phase 3]
Phase 3 clinical trial evaluating Olvi-Vec in combination with platinum-doublet chemotherapy and Bevacizumab versus physician's choice of ch…
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: Risk-reducing Strategies, Including Fimbriectomy, in Women With a Germline Mutation Predisposing to Ovarian or Pelvic Cancer [NA]
Clinical trial update on risk-reducing strategies, including fimbriectomy, for women with germline mutations predisposing to ovarian or pelv…
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CLINICAL_TRIALS research · 2026-03-06Clinical Trial Update: Using Advanced Imaging Studies to Develop a Profile of High-grade Serous Ovarian Cancer [NA]
This Memorial Sloan Kettering-led trial update describes using advanced imaging to develop an imaging-based profile of high-grade serous ova…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Neoadjuvant Aitua (PD-1/CTLA-4 Bispecific) Plus Nab-Paclitaxel and Carboplatin for Advanced High-Grade Serous Ovarian Cancer [Phase 2]
This is a Phase 2 neoadjuvant trial evaluating Aitua, a PD-1/CTLA-4 bispecific, with nab-paclitaxel and carboplatin in advanced high-grade s…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Immunotherapy Platform Study in Platinum Resistant High Grade Serous Ovarian Cancer [Phase 2]
A Phase 2 immunotherapy platform trial in platinum-resistant high-grade serous ovarian cancer is currently recruiting under the Canadian Can…
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CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: Prognostic Value of (DHODH) Expression in (HGSOC): A Comparative Study Between Neoadjuvant and Adjuvant Chemotherapy Settings
This clinical trial explores whether DHODH expression serves as a prognostic biomarker in high-grade serous ovarian cancer and compares its …
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Impact of Dietary Patterns on Prognosis of Ovarian Cancer Patients During PARPi Maintenance
A ClinicalTrials.gov update describes a study evaluating how dietary patterns affect prognosis for ovarian cancer patients during PARP inhib…
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CLINICAL_TRIALS research · 2025-12-05Clinical Trial Update: Minimal Residual Disease in Solid Malignancies [NA]
This clinical trial update describes a study evaluating minimal residual disease in solid malignancies across several cancers, and it is cur…
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CLINICAL_TRIALS research · 2025-10-22Clinical Trial Update: A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib [Phase 2]
A Phase 2 trial of Avutometinib (VS-6766) in combination with Defactinib is recruiting for several gynecologic cancers, including endometria…
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: A Study of Sovilnesib in Subjects With Ovarian Cancer [Phase 1]
Phase 1 study update of Sovilnesib in gynecologic cancers; the trial is active but not recruiting, investigating high-grade serous ovarian c…
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CLINICAL_TRIALS research · 2025-08-15Clinical Trial Update: Chemotherapy Combined With Propranolol Hydrochloride as Neoadjuvant Therapy for Advanced High-grade Serous Ovarian Cancer [Phase 2]
Phase 2 trial to assess neoadjuvant chemotherapy combined with propranolol hydrochloride for advanced high-grade serous ovarian cancer; stud…
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CLINICAL_TRIALS research · 2025-08-15Clinical Trial Update: 68Ga-FAPI PET/CT in the Staging of High-Grade Epithelial Ovarian Cancers: A Pilot Study [NA]
This is a pilot study evaluating Ga-68 labeled FAPI PET/CT for staging high-grade epithelial ovarian cancers, including high-grade serous ov…
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CLINICAL_TRIALS research · 2025-08-13Clinical Trial Update: Investigating Idetrexed and Olaparib in Patients With Ovarian Cancer [Phase 1]
A Phase 1 clinical trial is evaluating the combination of idetrexed and olaparib in patients with high-grade serous ovarian cancer; the stud…
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CLINICAL_TRIALS research · 2025-08-07Clinical Trial Update: Pembrolizumab and Lenvatinib for the Treatment of Serous Ovarian Cancer Patients [Phase 2]
A Phase 2 clinical trial update describes the combination of pembrolizumab and lenvatinib for high-grade serous cancers of the fallopian tub…
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CLINICAL_TRIALS research · 2025-04-30Clinical Trial Update: IN10018 in Combination With Standard Chemotherapy in High-grade Serous Epithelial Ovarian Cancer [Phase 1, Phase 2]
A Phase 1/2 trial (IN10018) evaluating IN10018 in combination with standard chemotherapy for high-grade serous epithelial ovarian cancer is …
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CLINICAL_TRIALS research · 2025-03-19Clinical Trial Update: Exploratory Study on HER2 Detection Method and Positive Threshold for High-grade Serous Adenocarcinoma of the Ovary
An exploratory clinical trial to refine HER2 detection criteria and positive thresholds in high-grade serous ovarian cancer and to observe t…