Hepatorenal Syndrome
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal Syndrome [Phase 2]
Phase 2 trial evaluating ambrisentan, an endothelin receptor antagonist, for hepatorenal syndrome; the study is currently active but not rec…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Initial Resuscitation for Acute Kidney Injury in Cirrhosis [NA]
Clinical trial recruiting to evaluate initial resuscitation for acute kidney injury in patients with cirrhosis.
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CLINICAL_TRIALS trial_result · 2026-03-10Clinical Trial Update: Comparison of Terlipressin Versus Octreotide in Patients With Hepatorenal Syndrome [NA]
A completed clinical trial comparing terlipressin versus octreotide in patients with hepatorenal syndrome.
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CLINICAL_TRIALS research · 2025-12-24Clinical Trial Update: Renal Histopathology and Transcriptomic Analysis in Hepatorenal Syndrome During Liver Transplantation [NA]
A clinical trial evaluating renal histopathology and transcriptomic analysis in hepatorenal syndrome occurring during liver transplantation;…
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CLINICAL_TRIALS trial_result · 2025-12-19Clinical Trial Update: Interest of the Echocardiography in the Management of Cirrhotic Patients With Acute Kidney Injury [NA]
The trial evaluated the role of echocardiography in the management of cirrhotic patients with hepatorenal syndrome and acute kidney injury. …
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CLINICAL_TRIALS trial_result · 2025-12-05Clinical Trial Update: Terlipressin in Combined Hepatorenal Syndrome in Patients With Signs of Chronic Renal Disease
Terlipressin was studied in a completed trial for combined hepatorenal syndrome in patients with signs of chronic kidney disease.
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CLINICAL_TRIALS trial_result · 2025-10-06Clinical Trial Update: The Selective Cytopheretic Device (SCD) for Acute Kidney Injury (AKI) and Hepatorenal Syndrome (HRS) Type I [NA]
The clinical trial evaluating the Selective Cytopheretic Device (SCD) for acute kidney injury and hepatorenal syndrome Type I has been suspe…
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: NEPH-ROSIS (NEPHrology in CirRhOSIS) Pilot Trial: A Trial to Treat Acute Kidney Injury Among Hospitalized Cirrhosis Patients [Phase 2, Phase 3]
NEPH-ROSIS, a Phase 2/3 pilot trial for treating acute kidney injury in hospitalized cirrhosis patients, has been terminated.
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CLINICAL_TRIALS research · 2024-12-16Clinical Trial Update: Use of Novel Plasma and Urinary Biomarkers to Predict the Development of Hepatorenal Syndrome in Cirrhotic Patients
This clinical trial update indicates ongoing recruitment for a study evaluating novel plasma and urinary biomarkers to predict the developme…
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CLINICAL_TRIALS research · 2024-11-20Clinical Trial Update: A Retrospective Analysis of Outcomes in Patients with Hepatorenal Syndrome At Methodist Dallas Medical Center
This clinical trial update describes a retrospective analysis of outcomes in patients with Hepatorenal Syndrome at Methodist Dallas Medical …
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CLINICAL_TRIALS research · 2024-11-18Clinical Trial Update: HRS-AKI Treatment With TIPS in Patients With Cirrhosis [NA]
Clinical trial update indicating recruitment for a study evaluating the use of transjugular intrahepatic portosystemic shunt (TIPS) to treat…
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CLINICAL_TRIALS trial_result · 2024-10-09Clinical Trial Update: Terlipressin for HRS-AKI in Liver Transplant Candidates (INFUSE) [Phase 3]
Phase 3 INFUSE trial evaluating terlipressin for hepatorenal syndrome with acute kidney injury in liver transplant candidates has completed …
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CLINICAL_TRIALS trial_result · 2023-12-15Clinical Trial Update: A Study of OCE-205 in Participants With Cirrhosis With Ascites Who Developed Hepatorenal Syndrome-Acute Kidney Injury [Phase 2]
Phase 2 trial assessing OCE-205 in participants with cirrhosis and ascites who developed hepatorenal syndrome-acute kidney injury has comple…
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CLINICAL_TRIALS trial_result · 2023-10-03Clinical Trial Update: Study to Evaluate R2R01 Plus Terlipressin Versus Terlipressin Alone in Patients With Hepatorenal Syndrome [Phase 2]
Phase 2 clinical trial comparing R2R01 plus terlipressin versus terlipressin alone in patients with hepatorenal syndrome and acute kidney in…
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CLINICAL_TRIALS trial_result · 2023-05-09Clinical Trial Update: Terlipressin Infusion Alone Vs Terlipressin With Noradrenaline Infusion In The Treatment of Hepatorenal Syndrome Type 1 [Phase 3]
Phase 3 trial comparing terlipressin infusion alone versus terlipressin with noradrenaline infusion for Type 1 hepatorenal syndrome; the stu…
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FDA label_change · 2023-01-09FDA Approved: TERLIVAZ — Supplemental Application (Mallinckrodt Hospital Products Inc.)
FDA approved a supplemental application for Terlivaz (terlipressin) by Mallinckrodt Hospital Products Inc., resulting in changes to labeling…
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CLINICAL_TRIALS trial_result · 2022-11-29Clinical Trial Update: A Placebo-Controlled, Double-Blind Study to Confirm the Reversal of Hepatorenal Syndrome Type 1 With Terlipressin [Phase 3]
Phase 3 trial assessing reversal of Hepatorenal Syndrome Type 1 with terlipressin; study completed with results posted.
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CLINICAL_TRIALS trial_result · 2022-11-21Clinical Trial Update: Rifaximin Prophylaxis for Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome in Cirrhotic Patients [Phase 2]
Phase 2 trial update on rifaximin prophylaxis for spontaneous bacterial peritonitis and hepatorenal syndrome in cirrhotic patients with asci…
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EMA guidance · 2022-11-11New recommendations for terlipressin-containing medicines in the treatment of hepatorenal syndrome
EMA has issued new recommendations for terlipressin-containing medicines used to treat hepatorenal syndrome, outlining updated safety and us…
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EMA guidance · 2022-09-30New recommendations for terlipressin-containing medicines in the treatment of hepatorenal syndrome
EMA issued new recommendations regarding terlipressin-containing medicines used to treat hepatorenal syndrome, outlining updated safety and …
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FDA approval · 2022-09-14FDA Approved: TERLIVAZ — Original Application (Mallinckrodt Hospital Products Inc.)
FDA approved TERLIVAZ (terlipressin) from Mallinckrodt Hospital Products Inc. as an original drug application for treatment of adults with h…
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CLINICAL_TRIALS trial_result · 2022-08-18Clinical Trial Update: Study To Confirm Efficacy and Safety of Terlipressin in Hepatorenal Syndrome (HRS) Type 1 [Phase 3]
Phase 3 trial evaluating terlipressin for hepatorenal syndrome type 1 has completed with posted results.
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CLINICAL_TRIALS trial_result · 2019-05-29Clinical Trial Update: Treatment of Type I Hepatorenal Syndrome (HRS) With Pentoxyfylline [NA]
Clinical trial update on treating Hepatorenal Syndrome with pentoxifylline; study is terminated with results posted.
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CLINICAL_TRIALS withdrawal · 2019-02-15Clinical Trial Update: Midodrine, Octreotide and Albumin: Impact on Renal Function of Patients With Liver Cirrhosis and Renal Failure [Phase 2]
A Phase 2 trial evaluating whether midodrine, octreotide, and albumin can improve renal function in patients with liver cirrhosis and renal …
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CLINICAL_TRIALS research · 2018-05-21Clinical Trial Update: Korean Cohort Study of AKI & HRS in Cirrhosis
A Korean cohort study investigating acute kidney injury and hepatorenal syndrome in patients with liver cirrhosis is being tracked, with the…