Hepatocellular Carcinoma

• CLINICAL_TRIALS research · 2026-03-25
  Clinical Trial Update: An Open-Label, Phase I Clinical Trial of Super CAR-T With GPC3-Positive Advanced Hepatocellular Carcinoma [Phase 1]

  An open-label Phase I study evaluating a Super CAR-T therapy targeting GPC3 in advanced hepatocellular carcinoma is currently recruiting.

• CLINICAL_TRIALS research · 2026-03-25
  Clinical Trial Update: Phase Ib/II Trial of Envafolimab Plus Lenvatinib for Subjects With Solid Tumors [Phase 1, Phase 2]

  A Phase Ib/II trial is evaluating the combination of Envafolimab (PD-L1 inhibitor) and lenvatinib in patients with solid tumors, including n…

• CLINICAL_TRIALS trial_result · 2026-03-24
  Clinical Trial Update: Evaluating the Effects of Selective Treatment Utilizing Flex-dosing for Unresectable HCC With Y90 SIR-Spheres

  A completed clinical trial assessed selective flex-dosing using Y-90 SIR-Spheres for unresectable hepatocellular carcinoma.

• CLINICAL_TRIALS research · 2026-03-24
  Clinical Trial Update: GNB4 and Riplet Gene Methylation Combined Detection Kit for Hepatocellular Carcinoma Recurrence Monitoring

  Clinical trial update on a diagnostic kit using GNB4 and Riplet gene methylation to monitor hepatocellular carcinoma recurrence. The study i…

• CLINICAL_TRIALS trial_result · 2026-03-24
  Clinical Trial Update: A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor [Phase 1, Phase 2]

  This entry provides a status update on a phase 1/2 study of Eisai's E7386 in combination with other anticancer drugs for solid tumors. The t…

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• CLINICAL_TRIALS research · 2026-03-24
  Clinical Trial Update: Combined Treatment of Durvalumab, Bevacizumab, Tremelimumab and Transarterial Chemoembolization (TACE) in Subjects With Hepatocellular Carcinoma or Biliary Tract Carcinoma [Phase 2]

  This update describes a Phase 2 trial evaluating durvalumab, bevacizumab, tremelimumab plus transarterial chemoembolization for hepatocellul…

• CLINICAL_TRIALS trial_result · 2026-03-23
  Clinical Trial Update: IMMULAB - Immunotherapy With Pembrolizumab in Combination With Local Ablation in Hepatocellular Carcinoma (HCC) [Phase 2]

  A phase 2 study evaluating pembrolizumab in combination with local tumor ablation for hepatocellular carcinoma has completed and posted resu…

• CLINICAL_TRIALS research · 2026-03-23
  Clinical Trial Update: Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV [Phase 1]

  This is a Phase 1 clinical trial evaluating the combination of cabozantinib (XL184) and nivolumab in patients with various advanced cancers …

• CLINICAL_TRIALS research · 2026-03-23
  Clinical Trial Update: Atezolizumab and Bevacizumab in Combination With Y^90 Radioembolization in HCC for Liver Transplant [Phase 4]

  Clinical trial update for a Phase 4 study evaluating atezolizumab and bevacizumab in combination with Y-90 radioembolization for hepatocellu…

• CLINICAL_TRIALS research · 2026-03-23
  Clinical Trial Update: cfDNA Methylation for Liver Cancer Recurrence Detection

  A prospective clinical trial is recruiting to evaluate cfDNA methylation as a biomarker for detecting recurrence in primary liver cancer.

• CLINICAL_TRIALS research · 2026-03-20
  Clinical Trial Update: Atezolizumab and Bevacizumab With Proton Radiotherapy for Unresectable Hepatocellular Carcinoma [Phase 2]

  Phase 2 clinical trial evaluating the combination of atezolizumab and bevacizumab with proton radiotherapy for unresectable hepatocellular c…

• CLINICAL_TRIALS research · 2026-03-20
  Clinical Trial Update: Prediction of Hepatocellular Carcinoma Recurrence After Curative Treatment by Longitudinal Monitoring MRD Based on ctDNA

  This clinical trial is evaluating whether longitudinal minimal residual disease monitoring using ctDNA can predict hepatocellular carcinoma …

• CLINICAL_TRIALS research · 2026-03-20
  Clinical Trial Update: Early Detection of Liver Cancer by QUS

  A CHUM-led clinical trial is evaluating quantitative ultrasound for the early detection of hepatocellular carcinoma. The study is currently …

• CLINICAL_TRIALS research · 2026-03-20
  Clinical Trial Update: Association Between Galectin-3 Levels and Outcomes in Patients With Renal Cell Carcinoma, Transitional Cell Carcinoma , Non Small Cell Lung Cancer, and Hepatocellular Carcinoma, Treated With PD-1/PDL-1 Inhibitors

  A clinical trial is investigating whether Galectin-3 levels predict outcomes in patients with renal cell carcinoma, urothelial carcinoma, no…

• CLINICAL_TRIALS trial_result · 2026-03-19
  Clinical Trial Update: A Study to Compare the Effectiveness and Safety of IBI310 Combined With Sintilimab Versus Sorafenib in the First-line Treatment of Advanced HCC [Phase 3]

  A Phase 3 trial comparing IBI310 plus Sintilimab versus Sorafenib as first-line treatment for advanced hepatocellular carcinoma has complete…

• CLINICAL_TRIALS research · 2026-03-19
  Clinical Trial Update: Efficacy and Safety of Camrelizumab Plus Rivoceranib and Local Therapy for Hepatocellular Carcinoma With Lung Metastases (CAPLocal) : A Multicentre, Single-Arm,Prospective Cohort Study

  This document outlines the CAPLocal study, a multicentre, single-arm prospective cohort evaluating camrelizumab plus rivoceranib with local …

• CLINICAL_TRIALS trial_result · 2026-03-19
  Clinical Trial Update: Treatment of Cabotamig (ARB202) in Advanced Gastrointestinal Cancer Patients [Phase 1]

  Phase 1 trial of Cabotamig (ARB202) in advanced gastrointestinal cancers has completed; no specific efficacy results are provided in the doc…

• CLINICAL_TRIALS trial_result · 2026-03-19
  Clinical Trial Update: Alectinib in Combination With Nivolumab in the Treatment of Recurrent or Refractory HCC Patients Guided With Serum RNase1 and Tumor Expression of PD-L1 [Phase 1]

  Phase 1 study evaluating alectinib in combination with nivolumab for recurrent or refractory hepatocellular carcinoma, guided by serum RNase…

• CLINICAL_TRIALS trial_result · 2026-03-19
  Clinical Trial Update: Individualized Surgical Guidance in HCC-BDTT

  Completed clinical trial investigating individualized surgical guidance for hepatocellular carcinoma with bile duct tumor thrombus.

• CLINICAL_TRIALS research · 2026-03-19
  Clinical Trial Update: A Multicenter Prospective Study on the Performance of Spectral CT for Evaluating Treatment Response After TACE in Hepatocellular Carcinoma

  A multicenter prospective study evaluating the use of spectral CT to assess treatment response after transarterial chemoembolization in hepa…

• CLINICAL_TRIALS research · 2026-03-19
  Clinical Trial Update: A Multicenter Clinical Study of Combined Therapy for Unresectable Hepatocellular Carcinoma [Phase 1, Phase 2]

  This document reports on a multicenter Phase 1/Phase 2 clinical trial evaluating a combined therapy for unresectable hepatocellular carcinom…

• CLINICAL_TRIALS research · 2026-03-19
  Clinical Trial Update: Conversion Therapy With FOLFOX-HAIC Plus Lenvatinib And Tislelizumab For Hepatocellular Carcinoma With Vp3 Portal Vein Tumor Thrombus [Phase 2]

  A Phase 2 trial evaluating conversion therapy with FOLFOX-HAIC plus lenvatinib and tislelizumab for hepatocellular carcinoma with portal vei…

• CLINICAL_TRIALS trial_result · 2026-03-19
  Clinical Trial Update: Selective Internal Radiation Therapy and 188Re-SSS Lipiodol Treatment for Liver Cancer (Lip-Re2) [Phase 2]

  Phase 2 trial update evaluating selective internal radiation therapy with 188Re-SSS Lipiodol for unresectable hepatocellular carcinoma. The …

• CLINICAL_TRIALS research · 2026-03-19
  Clinical Trial Update: Phase 2 Study of WGI-0301 for Advanced HCC [Phase 2]

  This document reports an ongoing Phase 2 clinical trial evaluating WGI-0301 for advanced hepatocellular carcinoma, which is currently recrui…

• CLINICAL_TRIALS research · 2026-03-19
  Clinical Trial Update: EUS Glue vs Endoscopic Variceal Band Ligation for Prevention of Rebleeding in Patients With HCC and EV Bleeding: a Retrospective Comparative Study

  A retrospective comparative study evaluating EUS-guided cyanoacrylate injection versus endoscopic variceal band ligation for preventing rebl…