Hepatocellular Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Impact of Interferon Free Regimens in Patients With Chronic HCV and Successfully Treated HCC [Phase 3]
A Phase 3 trial evaluated interferon-free regimens for patients with chronic hepatitis C who had been successfully treated for hepatocellula…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study to Determine Whether Chemotherapy and Atezolizumab is Better Than Chemotherapy, Bevacizumab and Atezolizumab in Patients With Advanced Liver Cancer [Phase 2]
This Phase 2 trial evaluates whether chemotherapy with atezolizumab is superior to chemotherapy with bevacizumab and atezolizumab in patient…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial [Phase 1, Phase 2]
A Phase 1/2 clinical trial (SAPHIRE) is evaluating adding sapanisertib to cabozantinib for advanced or metastatic hepatocellular carcinoma w…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Electronic Symptom Monitoring of Patient-Reported Outcomes Among Patients With Hepatocellular Carcinoma During Immunotherapy (PRIME-HCC): Protocol for a Randomised Controlled Trial [NA]
This document outlines the protocol for a randomized controlled trial evaluating electronic symptom monitoring of patient-reported outcomes …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Sequential FOLFOX-HAIC-TACE Plus Sintilimab-Bevacizumab Neoadjuvant Therapy Versus Direct Resection in Resectable High-Risk Recurrence Hepatocellular Carcinoma [Phase 1, Phase 2]
This clinical trial update outlines a Phase 1/2 study evaluating sequential FOLFOX-HAIC-TACE with sintilimab and bevacizumab as neoadjuvant …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: DNA Vaccine Therapy in Treating Patients With Chronic Hepatitis C Virus Infection [Phase 1]
This document reports a Phase 1 clinical trial evaluating a DNA vaccine therapy for chronic hepatitis C virus infection. The study is curren…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Trial of Casdozokitug in Combination With Toripalimab Plus Bevacizumab in Participants With Unresectable and/or Locally Advanced or Metastatic Hepatocellular Carcinoma [Phase 2]
The document provides a status update on a Phase 2 trial of Casdozokitug in combination with Toripalimab and Bevacizumab for unresectable/me…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma [Phase 1]
Phase 1 clinical trial update on QXL138AM assessing safety, pharmacokinetics, and preliminary efficacy in patients with solid tumors and mul…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Study of the Theranostic Pair RYZ811 (Diagnostic) and RYZ801 (Therapeutic) to Identify and Treat Subjects With GPC3+ (Glypican-3) Unresectable HCC [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating the theranostic pair RYZ811 (diagnostic) and RYZ801 (therapeutic) for Glypican-3 positive unresectable…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Radiofrequency Ablation for Hepatocellular Carcinoma Using Octopus MP Electrodes
Clinical trial update on a study of radiofrequency ablation for hepatocellular carcinoma using Octopus MP electrodes; the trial is active bu…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy [Phase 1, Phase 2]
Clinical trial evaluating oral 7HP349 (Alintegimod) in combination with ipilimumab, followed by nivolumab monotherapy, in patients with adva…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Enhanced Radiofrequency Ablation for Recurrent HCC Post-TACE Using Twin Internally Cooled-Perfusion Electrodes [NA]
A completed clinical trial evaluating enhanced radiofrequency ablation using twin internally cooled-perfusion electrodes for recurrent hepat…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial) [Phase 2]
This Phase 2 MATCH Screening Trial update describes ongoing evaluation of targeted therapies matched to genetic alterations in patients with…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: TheraBionic P1 Device in Subjects With Advanced Hepatocellular Carcinoma [NA]
The update indicates that a trial evaluating the TheraBionic P1 Device for advanced/recurrent hepatocellular carcinoma is currently recruiti…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Clinical Feasibility of Microwave Ablation Using Two Channel Microwave Generator and Two Antennas for Small Hepatocellular Carcinoma [NA]
This ClinicalTrials.gov update reports on the completed feasibility study of microwave ablation using a two-channel microwave generator and …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: CVM-1118 in Combination With Nivolumab for Unresectable Advanced Hepatocellular Carcinoma [Phase 2]
A Phase 2 clinical trial evaluating CVM-1118 in combination with nivolumab for unresectable advanced hepatocellular carcinoma is currently r…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Clinical Effectiveness of Microwave Ablation Using Starwave Microwave Generator for Hepatic Malignancies [NA]
A clinical trial update indicates a study evaluating microwave ablation with the Starwave Microwave Generator for hepatic malignancies is cu…
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EMA approval · 2026-04-09EMA Authorised: Sorafenib Accord (sorafenib tosilate) — Accord Healthcare S.L.U.
The EMA authorised Sorafenib Accord (sorafenib tosylate) for hepatocellular carcinoma and renal cell carcinoma. Accord Healthcare S.L.U. is …
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Neoadjuvant Tislelizumab-Lenvatinib vs Surgery Alone in Stage Ia HCC With Narrow Margin [Phase 2]
A Phase 2 trial compares neoadjuvant tislelizumab plus lenvatinib versus surgery alone in stage Ia hepatocellular carcinoma; the study is no…
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CLINICAL_TRIALS trial_result · 2026-04-09Clinical Trial Update: A Phase 1 Study of the Safety and Tolerability of CTX-10726 [Phase 1]
Phase 1 study update on the safety and tolerability of CTX-10726, currently recruiting across gastroesophageal cancer, hepatocellular carcin…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Streamlining Radioembolization for Small HCC
A recruiting clinical trial at Seoul National University Hospital is evaluating a streamlined radioembolization approach for small hepatocel…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Same-day Radioembolization for Large HCC
This clinical trial update indicates ongoing recruitment for same-day radioembolization treatment for large hepatocellular carcinoma.
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Atezolizumab Plus Bevacizumab With HCC and HBV Infection [NA]
Clinical trial update on atezolizumab plus bevacizumab for hepatocellular carcinoma, including patients with HBV infection. The study (NCT04…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Comparison of SBRT and SIRT With Combination IO for Locally-advanced, Unresectable HCCs (BIIRTH) [Phase 2, Phase 3]
A Phase 2/3 trial (BIIRTH) is evaluating SBRT or SIRT with combination immunotherapy for locally advanced, unresectable hepatocellular carci…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: MANDARIN (S6371) [Phase 3]
A Phase 3 clinical trial called MANDARIN (S6371) by Boston Scientific is currently active but not recruiting for inoperable hepatocellular c…