Hepatitis C
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CLINICAL_TRIALS withdrawal · 2018-06-08Clinical Trial Update: A Clinical Trial of 16 Weeks of Duration to Evaluate Retreatment With Elbasvir/Grazoprevir Plus Sofosbuvir and Ribavirin in Patients With Chronic Hepatitis C Genotypes 1,4 Who Have Failed to Treat With a Regime Based on an Inhibitor of the NS5A [Phase 4]
Phase 4 retreatment trial evaluating elbasvir/grazoprevir plus sofosbuvir and ribavirin in chronic hepatitis C genotypes 1 and 4 patients wh…
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CLINICAL_TRIALS trial_result · 2018-06-06Clinical Trial Update: Treatment of Egyptian Hepatitis C Genotype 4 Infected Children (and Adolescents) With Combined Sofosbuvir & Daclatasvir [Phase 3]
A Phase 3 trial in Egyptian children and adolescents with Hepatitis C genotype 4 evaluated the combination of Sofosbuvir and Daclatasvir; th…
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CLINICAL_TRIALS trial_result · 2018-05-24Clinical Trial Update: Safety & Efficacy of Sofosbuvir 400mg/Ledipasvir 90mg in the Treatment of Chronic Hepatitis C Adolescents [Phase 3]
Phase 3 trial update evaluating the safety and efficacy of the fixed-dose combination sofosbuvir/ledipasvir in adolescents with chronic hepa…
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CLINICAL_TRIALS trial_result · 2018-05-24Clinical Trial Update: The Prime Study - Comparing Hepatitis C Care and Treatment in a Primary Health Care Service With a Tertiary Hospital [NA]
A completed clinical trial update comparing hepatitis C care and treatment delivery in primary health care settings versus a tertiary hospit…
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EMA withdrawal · 2018-05-23EMA Withdrawn: Olysio (simeprevir) — Janssen-Cilag International NV
Olysio (simeprevir) has been withdrawn from the market by Janssen-Cilag International NV in relation to chronic hepatitis C.
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CLINICAL_TRIALS research · 2018-05-22Clinical Trial Update: Evaluation of Treatment of Chronic HCV Patients in Chronic Kidney Disease Versus End Stage Renal Disease Patients [Phase 1]
A Phase 1 clinical trial evaluating treatment of chronic Hepatitis C in patients with chronic kidney disease versus end-stage renal disease …
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CLINICAL_TRIALS trial_result · 2018-05-21Clinical Trial Update: Impact of Antiviral Therapy on Gastroesophageal Varices.
A completed clinical trial update evaluating the impact of antiviral therapy on gastroesophageal varices in chronic hepatitis C patients wit…
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CLINICAL_TRIALS trial_result · 2018-05-21Clinical Trial Update: Effectiveness, Safety and Clinical Outcomes of Paritaprevir/Ombitasvir/r+Dasabuvir 8 Weeks
This trial update reports on the effectiveness and safety outcomes of an eight-week regimen combining Paritaprevir, Ombitasvir, Ritonavir, a…
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CLINICAL_TRIALS research · 2018-05-18Clinical Trial Update: HepCare: The Effectiveness of Community Based Interventions With Peer Support to Improve Case Detection, Carry Out Pre-treatment Assessments and Assist Underserved Populations Through HCV Treatment
A clinical trial update describing the HepCare study, which evaluates community-based interventions with peer support to improve hepatitis C…
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CLINICAL_TRIALS trial_result · 2018-05-17Clinical Trial Update: SMV + SOF With/Without RBV for IFN-II Patients With CHC [Phase 4]
Phase 4 trial evaluating the combination of simeprevir and sofosbuvir, with or without ribavirin, in interferon-experienced chronic hepatiti…
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CLINICAL_TRIALS trial_result · 2018-05-15Clinical Trial Update: Safety and Efficacy of Sofosbuvir-based Regimens in Clinical Practice for the Treatment of Chronic Hepatitis C Virus Infection in India
This clinical trial update reports on the safety and efficacy of sofosbuvir-based regimens for chronic hepatitis C infection in real-world p…
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CLINICAL_TRIALS research · 2018-05-15Clinical Trial Update: The Staying Safe Intervention [NA]
This is an update on the Staying Safe Intervention trial related to Hepatitis C and opioid use; the phase and status are not specified.
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CLINICAL_TRIALS trial_result · 2018-05-09Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Experimental Drugs ABT- 493/ABT-530 in Adults With Chronic Hepatitis C Virus Genotype 1-6 Infection and Human Immunodeficiency Virus -1 Coinfection (EXPEDITION-2) [Phase 3]
Phase 3 trial EXPEDITION-2 evaluated ABT-493/ABT-530 for efficacy and safety in adults with chronic hepatitis C virus genotype 1-6 infection…
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CLINICAL_TRIALS trial_result · 2018-05-04Clinical Trial Update: A Gilead Sequence Registry of Subjects Who Did Not Achieve Sustained Virologic Response
A Gilead registry update describing outcomes for subjects who did not achieve sustained virologic response in chronic hepatitis C.
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CLINICAL_TRIALS research · 2018-05-03Clinical Trial Update: Strategic Screening for Infectious Diseases (Tuberculosis, HIV, HBV, HCV) Amongst Migrants in France
This clinical trial update describes a strategic screening initiative for HIV, Hepatitis B, Hepatitis C, and Tuberculosis among migrants in …
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CLINICAL_TRIALS trial_result · 2018-04-30Clinical Trial Update: Sofosbuvir, Ledipasvir, Ribavirin for Hepatitis C Cirrhotics, Genotype 1 [Phase 3]
Clinical trial update indicating completion of a Phase 3 study of Sofosbuvir, Ledipasvir, and Ribavirin for genotype 1 hepatitis C in patien…
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CLINICAL_TRIALS withdrawal · 2018-04-19Clinical Trial Update: Interferon-free Antiviral Treatment of HCV-Positive Genotype 1b Related Indolent Non-Hodgkin Lymphomas
A clinical trial evaluating interferon-free antiviral therapy for patients with Hepatitis C-positive genotype 1b–associated indolent non-Hod…
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CLINICAL_TRIALS trial_result · 2018-04-18Clinical Trial Update: Study of Hepatitis C Virus (HCV) Entry Inhibitor in Liver Transplant Recipients With HCV Infection [Phase 1]
A Phase 1 clinical trial of an HCV entry inhibitor in liver transplant recipients with hepatitis C infection has been terminated.
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CLINICAL_TRIALS trial_result · 2018-04-18Clinical Trial Update: Hepatitis C (HCV) Cure and Kidney Health
A clinical trial update on Hepatitis C cure and kidney health outcomes sponsored by the San Francisco Veterans Affairs Medical Center.
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CLINICAL_TRIALS withdrawal · 2018-04-17Clinical Trial Update: Improving Fibrosis Outcomes With Metformin [Phase 2]
A Phase 2 trial evaluating metformin for fibrosis outcomes has been withdrawn from the study.
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CLINICAL_TRIALS research · 2018-04-12Clinical Trial Update: Sysmex-XN 20 Analyser to Assess Lymphocyte Subsets and Other Haematological Parameters in Chronic/Acute Viral Infections
This clinical trial update describes evaluating the Sysmex-XN 20 hematology analyser to assess lymphocyte subsets and other haematological p…
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CLINICAL_TRIALS trial_result · 2018-04-11Clinical Trial Update: Efficacy and Safety of Ledipasvir/Sofosbuvir, With or Without Ribavirin, in HCV Infected Participants Who Have Failed Prior Treatment With Sofosbuvir-based Therapies [Phase 3]
Phase 3 trial evaluating ledipasvir/sofosbuvir with or without ribavirin in hepatitis C patients who failed prior sofosbuvir-based therapy; …
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CLINICAL_TRIALS research · 2018-04-10Clinical Trial Update: The TAP Study: Treating People Who Inject Drugs in Community-Based Settings Using a Social Network Approach [Phase 3]
Status update for the TAP Study, a Phase 3 clinical trial aimed at treating people who inject drugs in community settings using a social net…
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CLINICAL_TRIALS trial_result · 2018-04-09Clinical Trial Update: The Pathogenesis of Hepatitis C Virus Vertical Transmission
A completed clinical trial exploring the pathogenesis of vertical transmission of Hepatitis C virus from mother to child.
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CLINICAL_TRIALS trial_result · 2018-04-04Clinical Trial Update: A Study to Evaluate the Safety and Efficacy of ABT-493/ABT-530 in Adult Post-Liver or Post-Renal Transplant Recipients With Chronic Hepatitis C Virus (MAGELLAN-2) [Phase 3]
Phase 3 study evaluating ABT-493/ABT-530 in adult transplant recipients with chronic hepatitis C completed; results posted in 2018.