Hepatitis B
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CLINICAL_TRIALS trial_result · 2012-05-02Clinical Trial Update: Pegylated Interferon and Entecavir Combination in Chronic Hepatitis B (CHB) [Phase 1, Phase 2]
This document reports a Phase 1/2 clinical trial update evaluating a combination of pegylated interferon and entecavir for chronic hepatitis…
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CLINICAL_TRIALS withdrawal · 2012-05-02Clinical Trial Update: Efficacy and Safety of Telbivudine in Patients With Chronic Hepatitis B [Phase 4]
A Phase 4 trial of telbivudine for chronic hepatitis B has been withdrawn; the document provides no efficacy or safety data.
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CLINICAL_TRIALS trial_result · 2012-04-25Clinical Trial Update: Sorafenib Combined With Transarterial Chemoembolization in Treating HBV-infected Patients With Intermediate Hepatocellular Carcinoma [Phase 2]
Phase 2 clinical trial update evaluating sorafenib in combination with transarterial chemoembolization for HBV-infected patients with interm…
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CLINICAL_TRIALS trial_result · 2012-04-25Clinical Trial Update: A Double-Blind Randomized Clinical Trial Comparing the Safety and Antiviral Activity of 48-week Clevudine and Adefovir Dipivoxil in HBeAg(-) Chronic Hepatitis B With Compensated Liver Function [Phase 4]
A completed Phase 4 randomized, double-blind study comparing the safety and antiviral activity of 48 weeks of clevudine versus adefovir dipi…
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CLINICAL_TRIALS trial_result · 2012-04-23Clinical Trial Update: The Immunogenicity and Safety of 60mcg/30mcg Recombinant Hepatitis B Vaccines in People Who Failed to Respond to Routine Administration of Hepatitis B Vaccines [Phase 2, Phase 3]
Phase 2/3 trial assessing the immunogenicity and safety of a 60 mcg/30 mcg recombinant hepatitis B vaccine in individuals who did not respon…
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CLINICAL_TRIALS withdrawal · 2012-04-20Clinical Trial Update: Efficacy Study of Prednisone Priming to Treat Asian Chronic Hepatitis B Patients [NA]
A clinical trial evaluating prednisone priming as a treatment for chronic hepatitis B in Asian patients has been withdrawn (NCT00715715).
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CLINICAL_TRIALS trial_result · 2012-04-16Clinical Trial Update: Effect of Entecavir in Blacks/African Americans and Hispanics With Chronic Hepatitis B Virus (HBV) Infection [Phase 4]
Phase 4 trial updates Entecavir in Black/African American and Hispanic patients with chronic hepatitis B infection, with results posted in 2…
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CLINICAL_TRIALS research · 2012-04-16Clinical Trial Update: Long-term Safety and Efficacy Study of LB80380 in the Treatment-naive Patients of Chronic Hepatitis B [Phase 2]
A Phase 2 long-term safety and efficacy study of LB80380 in treatment-naive patients with chronic hepatitis B is underway. The current statu…
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CLINICAL_TRIALS trial_result · 2012-04-10Clinical Trial Update: Seroepidemiologic Study of Spermatozoal Transmission of Hepatitis B Virus (HBV)
Completed clinical trial assessing seroepidemiologic transmission of hepatitis B virus via spermatozoa.
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CLINICAL_TRIALS trial_result · 2012-03-08Clinical Trial Update: Effects of Short-term Atorvastatin Treatment on Vaccination Efficacy in Nonresponder Persons to Hepatitis B Vaccine [Phase 4]
Phase 4 trial investigating whether short-term atorvastatin can improve vaccination efficacy in individuals who did not respond to the Hepat…
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CLINICAL_TRIALS trial_result · 2012-02-28Clinical Trial Update: Effects of Telbivudine and Tenofovir Disoproxil Fumarate Treatment on the Hepatitis B Virus DNA Kinetics in CHB [Phase 3]
Phase 3 trial comparing telbivudine and tenofovir disoproxil fumarate in chronic hepatitis B evaluates HBV DNA kinetics; results were posted…
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CLINICAL_TRIALS trial_result · 2012-02-03Clinical Trial Update: Entecavir Plus Tenofovir Combination Therapy Versus Entecavir Monotherapy in Naive Subjects With Chronic Hepatitis B [Phase 3]
Phase 3 trial comparing entecavir plus tenofovir versus entecavir alone in treatment-naive chronic hepatitis B patients; the study has compl…
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CLINICAL_TRIALS trial_result · 2012-02-02Clinical Trial Update: Lamivudine Plus Adefovir Versus Telbivudine Plus Adefovir in Lamivudine Resistant Chronic Hepatitis B [Phase 3]
This Phase 3 trial update compares lamivudine plus adefovir against telbivudine plus adefovir in lamivudine-resistant chronic hepatitis B; t…
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CLINICAL_TRIALS trial_result · 2012-02-01Clinical Trial Update: Genetic Analysis of Liver Cancer
A clinical trial on genetic analysis of liver cancer has been terminated; no trial results are provided in the update.
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CLINICAL_TRIALS trial_result · 2012-01-20Clinical Trial Update: Cellular Immune Responses to Hepatitis B Virus (HBV)- Longitudinal Follow up and Natural History
A completed clinical trial update reporting longitudinal cellular immune responses to Hepatitis B virus and the natural history of infection…
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CLINICAL_TRIALS withdrawal · 2012-01-19Clinical Trial Update: Maraviroc Versus Etravirine In Combination With Antiretroviral Therapy In Drug Experienced HIV And Hepatitis Co-Infected Patients [Phase 4]
A Phase 4 trial comparing maraviroc versus etravirine in combination antiretroviral therapy for drug-experienced HIV patients co-infected wi…
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CLINICAL_TRIALS trial_result · 2011-12-21Clinical Trial Update: Evaluation of Antibody Persistence and Immune Memory Against the Hepatitis B Antigen in Previously Vaccinated Children [Phase 4]
Phase 4 trial evaluating antibody persistence and immune memory against hepatitis B antigen in children previously vaccinated.
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CLINICAL_TRIALS trial_result · 2011-12-13Clinical Trial Update: Antibody Persistence in Healthy Children After Primary and Booster DTaP-IPV-Hep B-PRP-T Vaccine or Control Vaccine
A clinical trial update reports antibody persistence in healthy children after primary and booster vaccination with DTaP-IPV-Hep B-PRP-T com…
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CLINICAL_TRIALS trial_result · 2011-12-08Clinical Trial Update: Efficacy and Safety of Dual-plasmid Hepatitis B Virus DNA Vaccine in Chronic Hepatitis B Patients [Phase 2]
Phase 2 trial evaluating the efficacy and safety of a dual-plasmid HBV DNA vaccine in chronic hepatitis B patients.
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FDA approval · 2011-12-02FDA Approved: LAMIVUDINE — Original Application (Apotex Corp.)
FDA approves Apotex Corp.'s original application for lamivudine (generic), authorizing its marketing for HIV-1 infection and chronic hepatit…
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CLINICAL_TRIALS research · 2011-11-29Clinical Trial Update: Effect of Antiviral Therapy on Host Immune in Patients With Chronic Hepatitis B Virus(HBV) Infection [NA]
A completed clinical trial assessed the impact of antiviral therapy on the host immune response in patients with HBeAg-positive chronic hepa…
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CLINICAL_TRIALS trial_result · 2011-11-22Clinical Trial Update: CHARM: Chronic Hepatitis B Antihepadnaviral Resistance Mutation Study
Clinical trial update for the CHARM study evaluating antihepadnaviral resistance mutations in chronic hepatitis B, sponsored by Gilead Scien…
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CLINICAL_TRIALS research · 2011-11-09Clinical Trial Update: Two Schedules of Hepatitis B Vaccination in Predialysis Chronic Renal Failure Patients [NA]
A completed clinical trial from Tehran University of Medical Sciences evaluating two dosing schedules of Hepatitis B vaccination in predialy…
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CLINICAL_TRIALS trial_result · 2011-11-07Clinical Trial Update: Pentavalent DTaP-Hep B-IPV [Phase 2]
Phase 2 trial of the pentavalent DTaP-Hep B-IPV vaccine has completed, evaluating protection against diphtheria, hepatitis B, poliomyelitis,…
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CLINICAL_TRIALS trial_result · 2011-11-03Clinical Trial Update: A Study of Switch From Nucleotide to Peginterferon Alfa-2a in CHB Patients Achieving HBeAg Loss and HBV DNA <200IU/ml [NA]
This clinical trial update evaluates switching CHB patients who achieved HBeAg loss and HBV DNA <200 IU/mL from nucleotide therapy to Pegint…