Hepatitis B
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CLINICAL_TRIALS trial_result · 2012-08-23Clinical Trial Update: Safety and Antiviral Activity of Entecavir in Participants With Chronic Hepatitis B Following Monotherapy in Other Entecavir Trials [Phase 2]
This Phase 2 trial update evaluates safety and antiviral activity of entecavir in chronic hepatitis B patients who previously received entec…
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CLINICAL_TRIALS trial_result · 2012-08-22Clinical Trial Update: Hepatitis B Antibody Persistence and Immune Response to Hepatitis B Vaccine Challenge in Previously Vaccinated Children [Phase 4]
Phase 4 trial update reporting persistence of Hepatitis B antibodies and immune response after a Hepatitis B vaccine challenge in children p…
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EMA withdrawal · 2012-08-16EMA Withdrawn: Hexavac (purified diphtheria toxoid;purified tetanus toxoid;purified pertussis toxoid;purified pertussis filamentous haemagglutinin;hepatitis B surface antigen;Inactivated Type 1 Poliovirus (Mahoney);Inactivated Type 3 Poliovirus (Saukett);Haemophilus influenzae type b polysaccharide) — Sanofi Pasteur MSD, SNC
The EMA has withdrawn Hexavac, a hexavalent combination vaccine, from the market. The decision was taken in 2012 and concerns multiple indic…
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CLINICAL_TRIALS trial_result · 2012-08-16Clinical Trial Update: Simvastatin for the Treatment of Chronic Hepatitis B [Phase 1]
This update reports a Phase 1 clinical trial evaluating Simvastatin for chronic hepatitis B has completed.
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CLINICAL_TRIALS trial_result · 2012-08-06Clinical Trial Update: Phase I Study to Investigate the Safety and Efficacy of HBV DNA Vaccine [Phase 1]
This trial update reports the completion of a Phase I study evaluating the safety and preliminary efficacy of an HBV DNA vaccine in chronic …
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CLINICAL_TRIALS trial_result · 2012-07-26Clinical Trial Update: Compare the Efficacy and Safety of 48-week Treatment With Clevudine 30mg Versus Lamivudine 100mg for CHB Infection [Phase 3]
Phase 3 trial comparing 48 weeks of clevudine 30 mg to lamivudine 100 mg for chronic hepatitis B. The update reports on efficacy and safety …
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CLINICAL_TRIALS trial_result · 2012-07-26Clinical Trial Update: Switching Study From Lamivudine to Clevudine in the Chronic Hepatitis B Patients [Phase 4]
This Phase 4 trial updates results of switching chronic hepatitis B patients from lamivudine to clevudine.
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CLINICAL_TRIALS trial_result · 2012-07-26Clinical Trial Update: Long-term Study With Clevudine [Phase 4]
This update reports the completion of a long-term Phase 4 study evaluating clevudine in chronic hepatitis B.
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CLINICAL_TRIALS trial_result · 2012-07-26Clinical Trial Update: An Open Study to Evaluate the Sustained Effect in Patients Showing Virological Responses With Muscle-related Symptom of Chronic Hepatitis B Patients Who Received Clevudine
This open-label trial evaluates the sustained virological effect and muscle-related safety in Chronic Hepatitis B patients who showed virolo…
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CLINICAL_TRIALS trial_result · 2012-07-11Clinical Trial Update: Effects of Telbivudine and Tenofovir Disproxil Fumarate on the Kinetics of Hepatitis B Virus DNA in Chronic Hepatitis B (CHB) [Phase 2]
A Phase 2 trial assessed how telbivudine and tenofovir disoproxil fumarate affect the kinetics of hepatitis B virus DNA in adults with chron…
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CLINICAL_TRIALS trial_result · 2012-07-04Clinical Trial Update: Entecavir Plus Adefovir Combination Therapy Versus Entecavir Monotherapy vs Therapy With Adefovir Plus Lamivudine for Chronic Hepatitis B Infected Subjects With Lamivudine-resistant Virus [Phase 3]
Phase 3 trial comparing entecavir plus adefovir versus entecavir alone and versus adefovir plus lamivudine in chronic hepatitis B patients w…
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CLINICAL_TRIALS research · 2012-07-04Clinical Trial Update: ST-2; a Non-invasive Fibrosis Marker for Chronic Hepatitis B
This entry provides an update on a clinical trial evaluating ST-2 as a non-invasive fibrosis marker for chronic hepatitis B.
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CLINICAL_TRIALS trial_result · 2012-06-22Clinical Trial Update: Dose-Ranging Study of Pradefovir in Patients With Compensated Hepatitis B [Phase 2]
A Phase 2 dose-ranging study evaluating pradefovir in patients with compensated chronic hepatitis B has completed.
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CLINICAL_TRIALS trial_result · 2012-06-20Clinical Trial Update: Optimization of Antiviral Therapy of Chronic HBV Infection
This clinical trial update reports on optimization strategies for antiviral therapy in chronic hepatitis B infection.
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CLINICAL_TRIALS research · 2012-06-01Clinical Trial Update: HBV DNA Levels During Pregnancy in Chronic Hepatitis B
Clinical trial update about HBV DNA levels during pregnancy in women with chronic hepatitis B; current status is unknown.
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CLINICAL_TRIALS trial_result · 2012-05-31Clinical Trial Update: Antiviral Activity of Entecavir in Patients Receiving Liver Transplant Due to Chronic Hepatitis B Virus Infection [Phase 3]
Phase 3 trial evaluating antiviral activity of entecavir in liver transplant recipients with chronic hepatitis B; results have been posted.
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CLINICAL_TRIALS trial_result · 2012-05-25Clinical Trial Update: Prednisolone Priming Study in Patients With Chronic Hepatitis B [Phase 4]
Phase 4 clinical trial investigating prednisolone priming in patients with chronic hepatitis B; current status is UNKNOWN.
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CLINICAL_TRIALS trial_result · 2012-05-15Clinical Trial Update: Efficacy of Peg-interferon α-2a in Hepatitis B Patients Treated by Entecavir Without HBeAg Loss [NA]
The update reports on the efficacy of pegylated interferon alfa-2a in Hepatitis B patients treated with entecavir who have not achieved HBeA…
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CLINICAL_TRIALS research · 2012-05-10Clinical Trial Update: Switch From Adefovir to Tenofovir in Chronic Hepatitis B for Suboptimal Response to Adefovir-based Combination Therapy [Phase 4]
Phase 4 clinical trial update describing a switch from adefovir to tenofovir for chronic hepatitis B patients with suboptimal response to ad…
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CLINICAL_TRIALS trial_result · 2012-05-08Clinical Trial Update: Continuing Lamivudine vs Switching to Entecavir in Patients With Detectable HBV DNA [Phase 4]
A Phase 4 clinical trial comparing continuing lamivudine versus switching to entecavir in patients with chronic hepatitis B and detectable H…
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CLINICAL_TRIALS trial_result · 2012-05-08Clinical Trial Update: Continuing Lamivudine Versus Switching to Entecavir in Patients Who Achieved Undetectable HBV DNA [Phase 4]
This Phase 4 clinical trial compares continuing lamivudine versus switching to entecavir in patients with chronic hepatitis B who have achie…
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CLINICAL_TRIALS research · 2012-05-08Clinical Trial Update: Prospective Observational Cohort Study for the Durability of Anti-viral Therapy in Patients With Chronic Hepatitis B
An observational cohort study designed to assess the durability of antiviral therapy in patients with chronic hepatitis B.
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CLINICAL_TRIALS trial_result · 2012-05-04Clinical Trial Update: Efficacy of Telbivudine Treatment at Long Term on the Absence of Liver Inflammation in Patients With Compensated Chronic Hepatitis B [Phase 4]
Phase 4 trial evaluating long-term telbivudine treatment for maintaining absence of liver inflammation in patients with compensated chronic …
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CLINICAL_TRIALS trial_result · 2012-05-02Clinical Trial Update: Efficacy of Telbivudine With or Without add-on Tenofovir According to Roadmap Strategy Compare With Entecavir [Phase 4]
Phase 4 clinical trial update evaluating the efficacy of telbivudine with or without add-on tenofovir compared with entecavir in chronic hep…
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CLINICAL_TRIALS research · 2012-05-02Clinical Trial Update: Assessment of HBV Vaccine Immunity After 18 Years
A clinical trial update assessing immunity to Hepatitis B vaccine 18 years after vaccination.