Hepatic Impairment
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-07-14Clinical Trial Results: GT-032 Belapectin Hepatic Impairment [Phase 1]
Phase 1 clinical trial results for GT-032 Belapectin in hepatic impairment were completed with results posted.
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CLINICAL_TRIALS trial_result · 2026-06-18Clinical Trial Results: Pharmacokinetics, Safety and Tolerability of ITF2357 in Participants With Chronic Hepatic Impairment and With Normal Hepatic Function [Phase 1]
Phase 1 trial results report pharmacokinetics, safety, and tolerability of ITF2357 in participants with chronic hepatic impairment compared …
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CLINICAL_TRIALS trial_result · 2026-03-19Clinical Trial Update: A Study About Fazirsiran in People With and Without Liver Problems [Phase 1]
Takeda's Phase 1 trial of Fazirsiran in people with and without hepatic impairment has completed, evaluating safety in individuals with vary…
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: A Clinical Study of MK-8527 in Participants With Mild and Moderate Hepatic Impairment (MK-8527-015) [Phase 1]
The Phase 1 study of MK-8527 in participants with mild and moderate hepatic impairment and in healthy participants has completed.
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CLINICAL_TRIALS trial_result · 2026-02-10Clinical Trial Update: A Study Evaluating How Moderate Liver Impairment Affects the Absorption, Distribution, Metabolism, and Elimination of Sevabertinib After a Single Oral Dose [Phase 1]
This Phase 1 pharmacokinetic study evaluated how moderate liver impairment affects the absorption, distribution, metabolism, and elimination…
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CLINICAL_TRIALS trial_result · 2025-03-21Clinical Trial Update: A Study to Compare How the Study Medicine (PF-07923568) is Processed in Participants With Different Levels of Loss of Liver Function to Healthy Participants. [Phase 1]
A Phase 1 pharmacokinetic study compared how PF-07923568 is processed in participants with hepatic impairment versus healthy participants; r…
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CLINICAL_TRIALS trial_result · 2025-01-22Clinical Trial Update: Study to Assess Drug Levels and Safety of BMS-986278 in Healthy Participants and Participants With Different Degrees of Hepatic Impairment [Phase 1]
A Phase 1 trial update reporting study NCT06425198 evaluating drug levels and safety of BMS-986278 in healthy participants and individuals w…
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CLINICAL_TRIALS trial_result · 2024-09-20Clinical Trial Update: Hepatic Impairment, Cholestatic Liver Disease, & NASH with Advanced Fibrosis & Normal Hepatic Function [Phase 1]
Phase 1 trial by Zydus Therapeutics evaluating hepatic impairment, cholestatic liver disease, and nonalcoholic steatohepatitis with advanced…
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CLINICAL_TRIALS trial_result · 2024-08-29Clinical Trial Update: A Study of TAK-279 in Adults With or Without Liver Damage [Phase 1]
This clinical trial update reports a Phase 1 study of TAK-279 in adults with hepatic impairment or in healthy volunteers that has completed.
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CLINICAL_TRIALS trial_result · 2024-02-16Clinical Trial Update: A STUDY TO COMPARE THE PHARMACOKINETICS OF PF-06835919 IN PARTICIPANTS WITH AND WITHOUT HEPATIC IMPAIRMENT [Phase 1]
A Phase 1 pharmacokinetics study comparing PF-06835919 in participants with hepatic impairment and healthy participants has completed with r…
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CLINICAL_TRIALS trial_result · 2024-02-02Clinical Trial Update: A Study of Soticlestat in Adults With Liver Failure Compared to Those With Normal Liver Function [Phase 1]
Phase 1 study evaluating soticlestat in adults with hepatic impairment versus healthy volunteers; completed with results posted.
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CLINICAL_TRIALS trial_result · 2023-11-30Clinical Trial Update: Steady-State Pharmacokinetics of Rifaximin 550 mg Tablets in Healthy and Hepatically Impaired Subjects [Phase 4]
Phase 4 trial update on steady-state pharmacokinetics of rifaximin 550 mg tablets in healthy and severely hepatic-impaired subjects; study t…
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CLINICAL_TRIALS trial_result · 2023-11-03Clinical Trial Update: A Study to Evaluate Pharmacokinetics (PK) and Safety of Oral Mobocertinib in Participants With Moderate or Severe Hepatic Impairment (HI) and Normal Hepatic Function [Phase 1]
Phase 1 study evaluating pharmacokinetics and safety of oral mobocertinib in participants with moderate to severe hepatic impairment and nor…
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CLINICAL_TRIALS trial_result · 2023-10-06Clinical Trial Update: A Study to Investigate the Influence of Hepatic Impairment on MK-8189 Treatment (MK-8189-012) [Phase 1]
Phase 1 trial updating on the influence of hepatic impairment on MK-8189 treatment has completed with results posted.
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CLINICAL_TRIALS trial_result · 2023-09-06Clinical Trial Update: Study to Estimate the Effects of Hepatic Impairment on the Pharmacokinetics (PK) of PF-07321332 [Phase 1]
Phase 1 study assessing how hepatic impairment affects the pharmacokinetics of PF-07321332 has been completed with results posted.
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CLINICAL_TRIALS trial_result · 2023-08-01Clinical Trial Update: A Study of Quizartinib Pharmacokinetics in Participants With Moderate Hepatic Impairment [Phase 1]
Phase 1 pharmacokinetic study of quizartinib in participants with moderate hepatic impairment has completed, with results posted in 2023.
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CLINICAL_TRIALS trial_result · 2023-05-11Clinical Trial Update: A Single and Repeat Dose Trial in Participants With Hepatic Impairment [Phase 1, Phase 2]
An early-phase clinical trial update evaluating single and repeat dosing in participants with hepatic impairment. Phase 1 and Phase 2 studie…
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CLINICAL_TRIALS trial_result · 2021-06-07Clinical Trial Update: Study of Pexidartinib in Participants With Moderate Hepatic Impairment Compared With Healthy Participants [EARLY_Phase 1]
Early-phase clinical trial comparing pexidartinib pharmacokinetics and safety in participants with moderate hepatic impairment versus health…
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CLINICAL_TRIALS trial_result · 2021-04-13Clinical Trial Update: Effect Of Hepatic Impairment on the Pharmacokinetics, Safety and Tolerability of PF-06865571 In Subjects With Hepatic Impairment and in Healthy Subjects [Phase 1]
Phase 1 study assessing the effect of hepatic impairment on pharmacokinetics, safety, and tolerability of PF-06865571 in subjects with hepat…
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CLINICAL_TRIALS trial_result · 2021-04-08Clinical Trial Update: A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of PF-06651600 in Subjects With Hepatic Impairment and Healthy Volunteers [Phase 1]
Phase 1 study evaluating pharmacokinetics, safety, and tolerability of PF-06651600 in hepatic impairment and healthy volunteers has complete…
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CLINICAL_TRIALS trial_result · 2020-11-06Clinical Trial Update: Evaluate Severe Hepatic Impairment on Dacomitinib PK [Phase 1]
Phase 1 trial update evaluating the pharmacokinetics of dacomitinib in patients with severe hepatic impairment.
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CLINICAL_TRIALS trial_result · 2020-05-18Clinical Trial Update: A Hepatic Impairment Study for PF-04965842. [Phase 1]
Phase 1 hepatic impairment study for PF-04965842 completed; results posted.
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CLINICAL_TRIALS trial_result · 2020-01-18Clinical Trial Update: Study to Evaluate the Pharmacokinetics of Lemborexant (E2006) and Its Metabolites in Subjects With Mild and Moderate Hepatic Impairment Compared to Healthy Subjects [Phase 1]
Phase 1 pharmacokinetics study of lemborexant and its metabolites in subjects with hepatic impairment versus healthy controls completed with…
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CLINICAL_TRIALS trial_result · 2019-09-25Clinical Trial Update: A Study to Evaluate the Effect of Hepatic Impairment on the Single Dose Pharmacokinetics (PK) of Intravenous TAK-954 [Phase 1]
Phase 1 study evaluating how hepatic impairment affects the single-dose pharmacokinetics of intravenous TAK-954; study completed with result…
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CLINICAL_TRIALS trial_result · 2019-08-08Clinical Trial Update: Study of PF-05221304 in Subjects With Varying Degrees of Hepatic Impairment [Phase 1]
Phase 1 trial evaluating PF-05221304 in subjects with varying degrees of hepatic impairment has completed; results posted in 2019.