Hepatic Encephalopathy
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-07-23Clinical Trial Update: Deprescribing Proton Pump Inhibitors to Reduce Post-TIPS Hepatic Encephalopathy [Phase 1, Phase 2]
This clinical trial update summarizes completed Phase 1/2 studies evaluating whether deprescribing proton pump inhibitors can reduce hepatic…
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CLINICAL_TRIALS research · 2025-06-10Clinical Trial Update: BCAA vs. Rifaximin in Patients With Cirrhosis for Secondary Prophylaxis of HE [Phase 4]
Phase 4 clinical trial comparing branched-chain amino acids to rifaximin for secondary prophylaxis of hepatic encephalopathy in patients wit…
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF) [Phase 1]
A Phase 1 trial assessing intravenous branched-chain amino acids for hepatic encephalopathy in patients with acute-on-chronic liver failure …
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CLINICAL_TRIALS trial_result · 2025-05-25Clinical Trial Update: FMT in Cirrhosis and Hepatic Encephalopathy [Phase 1, Phase 2]
This update reports the completed Phase 1 and Phase 2 trials of fecal microbiota transplantation for cirrhosis and hepatic encephalopathy, w…
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CLINICAL_TRIALS research · 2025-05-01Clinical Trial Update: Correlation Between Serum Albumin Level and Severity of Hepatic Encephalopathy in Patients With Chronic Liver Disease in Sohag University Hospital
This clinical trial at Sohag University Hospital is investigating whether serum albumin levels correlate with the severity of hepatic enceph…
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CLINICAL_TRIALS research · 2025-04-11Clinical Trial Update: 7.0T Magnetic Resonance Imaging Study for Hepatic Encephalopathy
Clinical trial update for a 7.0T MRI study investigating hepatic encephalopathy; the study is not yet recruiting.
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CLINICAL_TRIALS research · 2025-04-04Clinical Trial Update: A Study to Evaluate Role of Inhaled Amikacin to Prevent Ventilator Associated Pneumonia in Patients With Cirrhosis [Phase 4]
A Phase 4 trial is evaluating inhaled amikacin to prevent ventilator-associated pneumonia in patients with cirrhosis (including hepatic ence…
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CLINICAL_TRIALS trial_result · 2025-04-03Clinical Trial Update: Metobolomics in the Characterisation of HE
The document reports completion of a metabolomics study aimed at characterizing hepatic encephalopathy in patients with cirrhosis.
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FDA approval · 2025-03-14FDA Approved: LACTULOSE — Original Application (PAI Holdings, LLC dba PAI Pharma)
FDA approved an original application for lactulose as a generic drug, manufactured by PAI Holdings (dba PAI Pharma).
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CLINICAL_TRIALS trial_result · 2025-03-03Clinical Trial Update: Efficacy of Albumin Dialysis to Treat Patients With Hepatic Encephalopathy Using The Molecular Adsorbent Recirculating System (MARS) [NA]
A completed clinical trial evaluated the efficacy of albumin dialysis using the MARS system to treat hepatic encephalopathy in patients with…
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CLINICAL_TRIALS trial_result · 2025-02-13Clinical Trial Update: Description of Lactulose Administration by Balloon Rectal Tube in Severe Hepatic Encephalopathy
A completed clinical trial describes administering lactulose via a balloon rectal tube for severe hepatic encephalopathy.
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CLINICAL_TRIALS trial_result · 2025-02-13Clinical Trial Update: Effect of Brief Dietary Intervention on Ammonia Levels [NA]
This completed clinical trial evaluated whether a brief dietary intervention lowers ammonia levels in people with cirrhosis and hepatic ence…
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CLINICAL_TRIALS research · 2025-01-28Clinical Trial Update: Prevention of Post-TIPS Hepatic Encephalopathy by Administration of Rifaximin and Lactulose [Phase 4]
Phase 4 clinical trial update evaluating prophylaxis of post-TIPS hepatic encephalopathy using rifaximin and lactulose is currently recruiti…
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FDA approval · 2024-12-13FDA Approved: LACTULOSE — Original Application (Sun Pharmaceutical Industries, Inc.)
FDA approved a generic lactulose product from Sun Pharmaceutical Industries as an Original Application (ANDA 218858).
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CLINICAL_TRIALS research · 2024-12-02Clinical Trial Update: Diagnosing Minimal Hepatic Encephalopathy
A clinical trial update indicates that a study on diagnosing minimal hepatic encephalopathy is currently enrolling by invitation at Esbjerg …
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CLINICAL_TRIALS trial_result · 2024-11-26Clinical Trial Update: Efficacy of L-Ornithine L-Aspartate (LOLA) as an Adjunct to Branched Chain Amino Acids (BCAA) Enriched Solutions on Clinical Outcomes in ICU Patients With Hepatic Encephalopathy [Phase 4]
Phase 4 trial evaluating L-Ornithine L-Aspartate as an adjunct to BCAA-enriched solutions for Hepatic Encephalopathy in ICU patients; the st…
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CLINICAL_TRIALS trial_result · 2024-11-19Clinical Trial Update: TIPS Plus Transvenous Obliteration for Gastric Varices
A completed clinical trial evaluated the combination of transjugular intrahepatic portosystemic shunt (TIPS) with transvenous obliteration f…
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CLINICAL_TRIALS research · 2024-11-08Clinical Trial Update: Role of ALBI Score and Sarcopenia As Prognostic Predictors Among Hospitalized Cirrhotic Patients With Hepatic Encephalopathy
A clinical trial update describing a study that evaluates whether the ALBI score and sarcopenia can serve as prognostic predictors in hospit…
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FDA approval · 2024-09-17FDA Approved: LACTULOSE — Supplemental Application (Xttrium Laboratories, Inc.)
FDA approved a supplemental application for lactulose submitted by Xttrium Laboratories, Inc., authorizing a new generic lactulose product.
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CLINICAL_TRIALS withdrawal · 2024-08-01Clinical Trial Update: Characterization of Metabolomic Fingerprints in Patients With Acute Liver Failure and Acute-on-chronic Liver Failure With Hepatic Encephalopathy
A clinical trial investigating metabolomic fingerprints in patients with hepatic encephalopathy, acute liver failure, and acute-on-chronic l…
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CLINICAL_TRIALS trial_result · 2024-07-26Clinical Trial Update: Speech in Hepatic Encephalopathy (HE)
A clinical trial evaluating a speech-related intervention for hepatic encephalopathy has completed.
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CLINICAL_TRIALS trial_result · 2024-06-20Clinical Trial Update: A Study of Glyceryl Tri-(4-phenylbutyrate) Administered Orally as a Single Dose, and Twice Daily for Seven Consecutive Days to Subjects With Hepatic Impairment With Cirrhosis and to a Control Group [Phase 1]
A Phase 1 study evaluated the safety and pharmacokinetics of glyceryl tri-(4-phenylbutyrate) given as a single dose and twice-daily dosing f…
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CLINICAL_TRIALS trial_result · 2024-06-17Clinical Trial Update: A Study of MHE in Patients With Liver Diseases
This clinical trial update notes the completion of a study evaluating minimal hepatic encephalopathy in patients with liver diseases, includ…
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CLINICAL_TRIALS trial_result · 2024-05-07Clinical Trial Update: VE303 for Treatment of Hepatic Encephalopathy (HE) [Phase 2]
Phase 2 clinical trial results for VE303 in hepatic encephalopathy have been posted after completion of the study. The trial enrolled patien…
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CLINICAL_TRIALS research · 2024-04-30Clinical Trial Update: Hepatic Encephalopathy Prevention With Polydextrose After TIPS: Pilot Study (POEME) [NA]
A pilot study (POEME) is evaluating whether polydextrose can prevent hepatic encephalopathy after TIPS, and is currently recruiting.