Heart Failure
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CLINICAL_TRIALS trial_result · 2016-07-29Clinical Trial Update: Monitoring Community Trends in Heart Failure
The NHLBI-sponsored clinical trial studying community trends in heart failure has completed.
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CLINICAL_TRIALS trial_result · 2016-07-26Clinical Trial Update: Tolerability, Pharmacokinetics and Dopamine ß-hydroxylase (DßH) Inhibition Profile of BIA 5-453 [Phase 1]
Phase 1 clinical trial reports tolerability, pharmacokinetics, and Dopamine β-hydroxylase inhibition of the drug candidate BIA 5-453 in hype…
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CLINICAL_TRIALS trial_result · 2016-07-26Clinical Trial Update: Studies Investigating Co-morbidities Aggravating Heart Failure
This update reports on completed clinical studies examining how comorbidities, including Type 2 diabetes mellitus, may worsen heart failure.
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CLINICAL_TRIALS trial_result · 2016-07-21Clinical Trial Update: Tolerability, Pharmacokinetics and Pharmacodynamics of Six Multiple Rising Dose Regimens of BIA 5-453 [Phase 1]
Phase 1 study assessing tolerability, pharmacokinetics and pharmacodynamics of six multiple rising-dose regimens of BIA 5-453 in hypertensio…
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CLINICAL_TRIALS trial_result · 2016-07-21Clinical Trial Update: Outpatient Lung Impedance-Guided Preventive Therapy in Patients With Chronic Heart Failure (CHF) [Phase 3]
This is an update on a Phase 3 outpatient trial evaluating lung impedance-guided preventive therapy in patients with chronic heart failure.
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FDA approval · 2016-07-20FDA Approved: FUROSEMIDE — Original Application (Amneal Pharmaceuticals LLC)
FDA approved Amneal Pharmaceuticals LLC's original application for furosemide, authorizing a generic version of this diuretic.
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CLINICAL_TRIALS withdrawal · 2016-07-19Clinical Trial Update: EarlySense Monitoring Device Evaluation on COPD, CHF and Pneumonia Patients
A clinical trial evaluating the EarlySense monitoring device in patients with COPD, congestive heart failure, and pneumonia has been withdra…
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CLINICAL_TRIALS withdrawal · 2016-07-19Clinical Trial Update: EarlySense Monitoring Device Evaluation on CHF Patients
A clinical trial evaluating the EarlySense monitoring device in patients with congestive heart failure has been withdrawn from the registry.
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FDA approval · 2016-07-15FDA Approved: METOPROLOL SUCCINATE — Supplemental Application (BluePoint Laboratories)
FDA approved a supplemental application for metoprolol succinate from BluePoint Laboratories, enabling continued marketing of this generic b…
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CLINICAL_TRIALS withdrawal · 2016-07-14Clinical Trial Update: Study To Evaluate D-Ribose For The Treatment of Congestive Heart Failure [Phase 2]
A Phase 2 clinical trial evaluating D-Ribose for the treatment of congestive heart failure has been withdrawn.
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FDA approval · 2016-07-13FDA Approved: LISINOPRIL — Supplemental Application (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.(780779901))
FDA approved a supplemental application for lisinopril from Heritage Pharmaceuticals (Avet) under ANDA 076102 to authorize the generic produ…
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CLINICAL_TRIALS trial_result · 2016-07-13Clinical Trial Update: A Double-Blind Pharmacokinetic Interaction Study Evaluating the Effect of a Single IV Infusion of GGF2 or Placebo on Midazolam Pharmacokinetics in Patients With Heart Failure [Phase 1]
Phase 1 double-blind pharmacokinetic study to evaluate whether a single IV infusion of GGF2 or placebo alters midazolam pharmacokinetics in …
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CLINICAL_TRIALS trial_result · 2016-07-13Clinical Trial Update: Protected PCI Study
A clinical trial update on Abiomed's Protected PCI study related to heart failure.
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CLINICAL_TRIALS trial_result · 2016-07-12Clinical Trial Update: Digitalis Investigation Group (DIG) [Phase 3]
Phase 3 DIG trial evaluating digoxin for arrhythmias and heart failure has completed.
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CLINICAL_TRIALS trial_result · 2016-07-12Clinical Trial Update: Enalapril After Anthracycline Cardiotoxicity [Phase 3]
This is a Phase 3 trial evaluating enalapril after anthracycline cardiotoxicity. The study status is completed.
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CLINICAL_TRIALS trial_result · 2016-07-12Clinical Trial Update: Genetic Architecture of Heart Disease in Rural Brazil
This NHLBI-sponsored, completed trial investigated the genetic architecture of heart disease in rural Brazil, including participants with Ch…
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CLINICAL_TRIALS research · 2016-07-12Clinical Trial Update: Peritoneal Ultrafiltration to Treat Congestive Heart Failure
This entry provides an update on a clinical trial evaluating peritoneal ultrafiltration as a treatment for congestive heart failure, sponsor…
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CLINICAL_TRIALS research · 2016-07-11Clinical Trial Update: Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-2) Trial - THE CHART-2 TRIAL [Phase 3]
Phase 3 trial CHART-2 is evaluating Cardiopoietic Regenerative Therapy for heart failure; the current status is listed as UNKNOWN.
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CLINICAL_TRIALS trial_result · 2016-07-07Clinical Trial Update: Heart Failure Re-admission Risk Estimation Using NICaS System With Comparison to Serum BNP Levels [NA]
A completed clinical trial evaluating the NICaS System for estimating readmission risk in heart failure patients, comparing its performance …
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CLINICAL_TRIALS trial_result · 2016-07-07Clinical Trial Update: Preoperative Significant Clinical Findings Using Focused Ultrasound Examination
Clinical trial update reporting preoperative significant clinical findings detected with focused ultrasound in patients with heart failure.
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CLINICAL_TRIALS trial_result · 2016-07-07Clinical Trial Update: Optimization of the Treatment of Acute HF by a Non Invasive Cardiac System-a Randomized Control Trial [NA]
A randomized controlled trial evaluated a non-invasive cardiac system for acute heart failure. Kidney injury was among the conditions studie…
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CLINICAL_TRIALS trial_result · 2016-07-01Clinical Trial Update: Safety and Hemodynamic Effects and Pharmacokinetics of CXL-1020 in Patients With Stable Heart Failure [Phase 1, Phase 2]
Phase 1/2 trial update reporting safety, hemodynamic effects, and pharmacokinetics of the investigational agent CXL-1020 in patients with st…
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CLINICAL_TRIALS trial_result · 2016-07-01Clinical Trial Update: An Observational Study of the Functional Capacity of Heart Failure [NA]
This document reports a completed observational study assessing the functional capacity of patients with acute heart failure. Sponsor is Bri…
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FDA approval · 2016-06-30FDA Approved: ETHACRYNIC ACID — Original Application (Edenbridge Pharmaceuticals LLC.)
The FDA approved Edenbridge Pharmaceuticals' original application for Ethacrynic acid, a loop diuretic used to treat edema associated with h…
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CLINICAL_TRIALS trial_result · 2016-06-24Clinical Trial Update: Deutsches Device Qualitätsregister
The German Device Qualitätsregister study, focused on heart failure, has completed.