Heart Failure with Preserved Ejection Fraction
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CLINICAL_TRIALS research · 2026-01-06Clinical Trial Update: The Relationship Between Epicardial Fat Tissue and Cardiac Function in HFpEF Patients
A completed clinical trial investigating the relationship between epicardial fat tissue and cardiac function in patients with Heart Failure …
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CLINICAL_TRIALS research · 2026-01-06Clinical Trial Update: Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction [Phase 2]
Phase 2 clinical trial update on using metformin in older patients with heart failure with preserved ejection fraction; the study is current…
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CLINICAL_TRIALS trial_result · 2025-12-29Clinical Trial Update: Enavogliflozin Outcome Trial in Functional Tricuspid Regurgitation [Phase 3]
Phase 3 trial evaluating enavogliflozin for functional tricuspid regurgitation in patients with heart failure with preserved ejection fracti…
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: Study on the Efficacy and Safety of HRS-7535 in Patients With Mild Decrease in Ejection Fraction/Preserved Ejection Fraction Heart Failure and Obesity [Phase 2]
A Phase 2 clinical trial evaluating the efficacy and safety of HRS-7535 in adults with heart failure with reduced or preserved ejection frac…
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CLINICAL_TRIALS research · 2025-12-26Clinical Trial Update: AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure [NA]
AlEX-DHF is a clinical trial evaluating ablation and exercise as treatments for diastolic heart failure in patients with preserved ejection …
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CLINICAL_TRIALS research · 2025-12-24Clinical Trial Update: Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
A clinical trial is examining links between the gut microbiome, skeletal muscle perfusion, and fitness status. The study includes participan…
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CLINICAL_TRIALS trial_result · 2025-12-23Clinical Trial Update: Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction [NA]
This clinical trial update reports the completion of a study evaluating exercise stress echocardiography in patients with heart failure with…
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: Imaging Histone Deacetylase in the Heart [NA]
Massachusetts General Hospital is conducting a recruiting clinical trial to image histone deacetylase activity in the heart, exploring its r…
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CLINICAL_TRIALS research · 2025-12-19Clinical Trial Update: Sacubitril-Valsartan in Heart Failure With Preserved Ejection Fraction and Secondary Mitral Valve Regurgitation [Phase 4]
Phase 4 trial update for sacubitril/valsartan in heart failure with preserved ejection fraction and functional mitral regurgitation. The stu…
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: The Prevalence of Iron Deficiency and the Effectiveness of Ferinject® in Patients With HFpEF (ID-HFpEF) [Phase 4]
Phase 4 trial evaluating the prevalence of iron deficiency and the effectiveness of Ferinject in patients with heart failure with preserved …
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) [Phase 2]
Phase 2 study evaluating safety, tolerability, and drug levels of BMS-986435/MYK-224 in participants with heart failure with preserved eject…
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CLINICAL_TRIALS trial_result · 2025-12-15Clinical Trial Update: Study to Evaluate Sex Differences in the Acute Effects of PL-3994 in Heart Failure Subjects [Phase 2]
The Phase 2 study evaluating sex differences in the acute effects of PL-3994 in heart failure with preserved ejection fraction has been term…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: SHort Of Pace - Heart Failure (SHOP-HF) [NA]
A clinical trial named SHOP-HF (Short Of Pace) studying heart failure with preserved ejection fraction is currently recruiting. The sponsor …
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Comparative Effectiveness of Tirzepatide vs Semaglutide in Participants With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction
This clinical trial compares tirzepatide to semaglutide in people with type 2 diabetes mellitus and heart failure with preserved ejection fr…
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CLINICAL_TRIALS research · 2025-12-09Clinical Trial Update: Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure
Clinical trial registry update for a Biomechanical Precision Medicine Registry in patients with and without heart failure; the study is curr…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: A Phase II Clinical Trial of HRS-1893 in the Treatment of Heart Failure With Preserved Ejection Fraction [Phase 2]
Phase II clinical trial evaluating HRS-1893 for heart failure with preserved ejection fraction, currently not yet recruiting.
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: CASTLE-HFpEF (Catheter Ablation for Atrial Fibrillation Patients With Heart Failure With Mildly Reduced and Preserved Ejection Fraction) [NA]
Clinical trial status update for CASTLE-HFpEF evaluating catheter ablation in patients with atrial fibrillation and heart failure with prese…
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CLINICAL_TRIALS trial_result · 2025-12-03Clinical Trial Update: Empagliflozin on Patients With Preserved Heart Failure [NA]
A clinical trial evaluating empagliflozin in patients with heart failure with preserved ejection fraction has completed.
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CLINICAL_TRIALS trial_result · 2025-11-26Clinical Trial Update: Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes [Phase 3]
Phase 3 trial update indicates the completion of a study evaluating semaglutide for heart failure with preserved ejection fraction and type …
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Effects of a Multicomponent Training Program on Cardiac Function, Skeletal Muscle Metabolism, Functional Capacity, and Quality of Life in Patients With HFpEF: SENSORFIT-4HEART Study [NA]
An ongoing clinical trial (SENSORFIT-4HEART) is evaluating the effects of a multicomponent training program on cardiac function and related …
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: HRS9531 Injection in Obese Subjects With Heart Failure With Preserved Ejection Fraction [Phase 2]
Phase 2 clinical trial evaluating HRS9531 injections in obese adults with heart failure with preserved ejection fraction; the study is curre…
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Diagnosing Heart Failure With Preserved Ejection Fraction in Patients With Unexplained Dyspnea (Diagnose-HFpEF)
A clinical trial update about diagnosing heart failure with preserved ejection fraction in patients with unexplained dyspnea.
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Cardiovascular and Renal Endpoints With Flozins - an Observational Prospective Study in CKD HFpEF Patients
An observational prospective study investigating cardiovascular and renal outcomes of SGLT2 inhibitors (flozins) in CKD patients with heart …
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Preserved Ejection Fraction (Cycle-2-PEF) [Phase 2]
The Phase 2 trial Cycle-2-PEF evaluating Tovinontrine for heart failure with preserved ejection fraction has completed, reporting on safety …
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CLINICAL_TRIALS research · 2025-11-17Clinical Trial Update: Leg Heat Therapy in Heart Failure With Preserved Ejection Fraction [NA]
The update indicates a clinical trial examining leg heat therapy for heart failure with preserved ejection fraction is currently recruiting.