Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-22Clinical Trial Update: A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors [Phase 1]
This first-in-human Phase 1 trial update reports ALX2004 for advanced or metastatic solid tumors and notes that the study is currently recru…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors [Phase 2]
This Phase 2 trial update evaluates the efficacy and safety of tisotumab vedotin in solid tumors. It includes colorectal cancer, non-small c…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment [Phase 3]
Phase 3 clinical trial evaluating the addition of cetuximab to pembrolizumab for recurrent or metastatic head and neck squamous cell carcino…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: A Phase 1 of CTX-8371 in Patients With Advanced Malignancies [Phase 1]
Phase 1 clinical trial evaluating CTX-8371 in patients with advanced malignancies, including Non-Small Cell Lung Cancer and Triple-Negative …
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors [Phase 1]
Phase 1 clinical trial update showing LY4052031 being studied in advanced or metastatic urothelial cancer and other solid tumors; the study …
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: Study of CTX-471 as a Monotherapy or in Combination With Pembrolizumab in Patients Post PD-1/PD-L1 Inhibitors in Metastatic or Locally Advanced Malignancies [Phase 1]
Phase 1 trial evaluating CTX-471 as a monotherapy or in combination with pembrolizumab in patients who progressed after PD-1/PD-L1 inhibitor…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 clinical trial evaluating pembrolizumab given alone versus the standard chemotherapy with radiation after surgery for recurrent head…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Postoperative Radiotherapy Combined With Nimotuzumab Followed by Benmelstobart in High-Risk Patients With Head and Neck Squamous Cell Carcinoma [Phase 3]
A Phase 3 study is evaluating postoperative radiotherapy plus Nimotuzumab followed by Benmelstobart in high-risk head and neck squamous cell…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Postoperative Radiotherapy With Nimotuzumab ± Benmelstobart in Intermediate-Risk Head and Neck Squamous Cell Carcinoma: A Randomized Controlled Trial [Phase 2, Phase 3]
A randomized study is evaluating postoperative radiotherapy with Nimotuzumab, with or without Benmelstobart, for intermediate-risk head and …
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer [Phase 1]
A Phase 1 clinical trial is evaluating the addition of the AKT inhibitor ipatasertib to standard chemotherapy and radiation for locally adva…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design [Phase 2]
This Phase 2 trial compares radiotherapy with cisplatin versus a docetaxel-cetuximab regimen in head and neck squamous cell carcinoma, focus…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer [Phase 2]
Phase 2 trial evaluating cemiplimab plus CDX-1140 given before surgery to determine if the combination improves outcomes versus cemiplimab a…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: 3D Specimen Maps for RT Planning
A Vanderbilt University Medical Center trial update describes 3D specimen maps to aid radiation therapy planning for head and neck cancers. …
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: Dose Finding Study of TNO155 in Adult Patients With Advanced Solid Tumors [Phase 1]
Novartis' Phase 1 dose-finding trial of TNO155 in adults with advanced solid tumors has been terminated. No efficacy results are provided in…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: A Bidirectional Study of Individualized Postoperative Adjuvant Treatment Decision Model for Locally Advanced Head and Neck Squamous Cell Carcinoma Based on Multimodal Dynamic Data
This clinical trial update describes an ongoing bidirectional study to develop an individualized postoperative adjuvant treatment decision m…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell Cancer [Phase 2]
Phase 2 clinical trial update evaluating metronomic cyclophosphamide and etoposide for advanced head and neck squamous cell carcinoma; statu…
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: OSI-774/Cisplatin/Taxotere in Head & Neck Squamous Cell Cancer [Phase 2]
Phase 2 trial evaluating the combination of OSI-774 (gefitinib) with cisplatin and docetaxel in head and neck squamous cell carcinoma; resul…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: The SWOAR Trial Sparing of Swallowing and Aspiration Related Organs at Risk & Submandibular Gland With Intensity Modulated Radiotherapy Versus Standard IMRT in Head and Neck Squamous Cell Carcinomas [Phase 3]
A Phase 3 trial update describing SWOAR-sparing IMRT compared with standard IMRT for head and neck squamous cell carcinoma; currently not re…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: CUE-101with Pembrolizumab for LA-HPV+HNSCCs [Phase 2]
This ClinicalTrials.gov entry describes a Phase 2 trial evaluating CUE-101 in combination with Pembrolizumab for locally advanced, HPV-posit…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma [Phase 1, Phase 2]
A Phase 1/2 clinical trial update describes evaluating PD-1 inhibition with neoadjuvant proton or photon radiation therapy for recurrent hea…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1 [Phase 2, Phase 3]
A Phase 2/3 clinical trial is evaluating BNT113 in combination with pembrolizumab versus pembrolizumab alone for HPV16-positive, PD-L1-expre…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Study of XB010 in Subjects With Solid Tumors [Phase 1]
A Phase 1 trial evaluating XB010 in locally advanced or metastatic solid tumors is currently recruiting across multiple indications.
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Phase Ib/II Study of an Anti-HER3 Antibody, HMBD-001, With Cetuximab +/- Docetaxel in Advanced Squamous Cell Cancers [Phase 1, Phase 2]
A Phase Ib/II clinical trial evaluating HMBD-001, an anti-HER3 antibody, in combination with cetuximab with or without docetaxel for advance…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors [Phase 1]
Phase 1 clinical trial evaluating IACS-6274 with or without Bevacizumab and Paclitaxel in adults with advanced solid tumors; the study is cu…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors [Phase 1]
Phase 1 clinical trial update for Enzelkitug as a single agent and in combination with a checkpoint inhibitor in adults with locally advance…