Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-01-28Clinical Trial Update: Pembrolizumab Plus Olaparib in LA-HNSCC [Phase 2]
A phase 2 trial evaluating pembrolizumab in combination with olaparib for locally advanced head and neck squamous cell carcinoma is currentl…
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: Toripalimab ± Chemo as Neoadjuvant Therapy in LA-HNSCC: A Phase III Trial [Phase 3]
A Phase III clinical trial is planned to evaluate toripalimab with or without chemotherapy as neoadjuvant therapy for locally advanced head …
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: Comparison of Efficacy Between De-escalated Surgery and Standard Surgery After Neoadjuvant Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma [NA]
A clinical trial comparing de-escalated surgery to standard surgery after neoadjuvant immunotherapy in locally advanced head and neck squamo…
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CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers [EARLY_Phase 1]
An early-phase 1 trial at Brigham and Women's Hospital is screening a novel IMD drug in patients with salivary gland cancers and head and ne…
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CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: SYS6010 Combined With Enlonstobart In Recurrent Or Metastatic Head And Neck Squamous Cell Carcinoma [Phase 2]
A Phase 2 clinical trial update assessing SYS6010 in combination with Enlonstobart for recurrent or metastatic head and neck squamous cell c…
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CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer [Phase 1]
Phase 1 clinical trial evaluating decitabine in combination with standard-of-care therapy for surgically resectable HPV-negative head and ne…
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CLINICAL_TRIALS trial_result · 2026-01-23Clinical Trial Update: First in Human Study of SIM0610 in Solid Tumors [Phase 1]
A first-in-human Phase 1 study of SIM0610 in solid tumors is underway, evaluating safety and dosing across multiple indications including No…
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CLINICAL_TRIALS trial_result · 2026-01-23Clinical Trial Update: Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene Amplifications [Phase 1]
A Phase 1 clinical trial update describes evaluation of BBI-355 (CHK1 inhibitor) in combination with BBI-825 (RNR inhibitor) for tumors with…
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CLINICAL_TRIALS trial_result · 2026-01-23Clinical Trial Update: NBTXR3, Radiation Therapy, and Pembrolizumab for the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Cancer [Phase 2]
A Phase 2 trial evaluating NBTXR3 with radiation therapy and pembrolizumab for recurrent or metastatic head and neck squamous cell carcinoma…
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CLINICAL_TRIALS research · 2026-01-23Clinical Trial Update: Study to Evaluate the Safety and Efficacy of Oral NRC-2694-A in Combination With Paclitaxel in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma, Who Progressed on or After Immune Checkpoint Inhibitor Therapy [Phase 2]
A Phase 2 clinical trial is evaluating safety and efficacy of oral NRC-2694-A in combination with paclitaxel for recurrent and/or metastatic…
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CLINICAL_TRIALS research · 2026-01-23Clinical Trial Update: Intensive Symptom Surveillance Guided by Machine Learning-Directed Risk Stratification in Patients With Non-Metastatic Head and Neck Cancer, The INSIGHT Trial [NA]
Clinical trial update for the INSIGHT trial using machine-learning-directed risk stratification to guide intensive symptom surveillance in n…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: First in Human Study of QLS5316 in Solid Tumors [Phase 1]
This is a first-in-human Phase 1 trial of QLS5316 in various solid tumors; the study is not yet recruiting.
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CLINICAL_TRIALS trial_result · 2026-01-22Clinical Trial Update: A Phase 1 Study in Patients With HPV16+ Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma [Phase 1]
A Phase 1 clinical trial conducted by Cue Biopharma in patients with HPV16-positive recurrent or metastatic head and neck squamous cell carc…
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CLINICAL_TRIALS trial_result · 2026-01-21Clinical Trial Update: Predictive Value of Diffusion-weighted MRI Performed in Early Post-treatment in the Occurrence of Tumor Recurrence or Progression in Head and Neck Squamous Cell Carcinoma Treated With Chemoradiotherapy: a Pilot Study [NA]
This completed pilot study evaluated diffusion-weighted MRI performed early after chemoradiotherapy to predict recurrence or progression in …
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CLINICAL_TRIALS trial_result · 2026-01-21Clinical Trial Update: HPV-E6-Specific Anti-PD1 TCR-T Cells in the Treatment of HPV-Positive NHSCC or Cervical Cancer [Phase 1]
Phase 1 trial of HPV-E6-specific anti-PD1 TCR-T cells for HPV-positive cervical cancer and head and neck squamous cell carcinoma has complet…
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer [Phase 1]
A Phase 1 clinical trial update examining multiple drug combinations including BI 765063, Ezabenlimab, Cetuximab, and BI 836880 for head and…
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CLINICAL_TRIALS trial_result · 2026-01-21Clinical Trial Update: A Study of SI-B001+SI-B003 Combined With Platinum-based Chemotherapy as First-line Treatment in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 clinical trial evaluating SI-B001 and SI-B003 in combination with platinum-based chemotherapy as first-line treatment for recurrent …
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: A Single-Arm Phase II Clinical Study of Docetaxel Combined With Nimotuzumab and Pucotenlimab as Second-Line and Beyond Therapy for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma [Phase 2]
A single-arm Phase II clinical trial evaluating docetaxel combined with nimotuzumab and pucotenlimab as second-line and beyond therapy for r…
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CLINICAL_TRIALS trial_result · 2026-01-20Clinical Trial Update: EBV-Specific Anti-PD1 TCR-T Cells in the Treatment of EBV-Positive NHSCC [Phase 1, Phase 2]
Clinical trial update reporting completion of Phase 1/2 study evaluating EBV-specific anti-PD1 TCR-T cells for EBV-positive head and neck sq…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: A Study of HB-202/HB-201 in People With Human Papilloma Virus 16-Positive Head and Neck Squamous Cell Cancer (HPV 16+ HNSCC) [EARLY_Phase 1]
Clinical trial update describes an early-phase (Phase 1) study of HB-202 and HB-201 in HPV16-positive head and neck squamous cell carcinoma;…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: SBRT +/- Pembrolizumab in Patients With Local-Regionally Recurrent or Second Primary Head and Neck Carcinoma [Phase 2]
A Phase 2 clinical trial is evaluating stereotactic body radiotherapy with or without pembrolizumab for local-regionally recurrent or second…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: A Trial of Locoregionally Advanced Squamous Cell Carcinoma of The Head and Neck [Phase 2]
Phase 2 clinical trial exploring locoregionally advanced head and neck squamous cell carcinoma, currently not yet recruiting.
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer [Phase 1]
Phase 1 trial evaluating intratumoral delivery of saRNA particles expressing IL-12 for head and neck cancers is currently recruiting.
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400 [Phase 1]
Phase 1 study assessing adverse events and change in disease activity in adults with select advanced solid tumors treated with ABBV-400; the…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Postoperative Radiotherapy for Intermediate- and High-risk Patients With HNSCC Greater Than 6 Weeks After Surgery [NA]
A Wake Forest trial is evaluating postoperative radiotherapy for intermediate- and high-risk head and neck squamous cell carcinoma patients …