Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-06-26Clinical Trial Update: Study to Assess the Efficacy and Safety of Nivolumab in Combination With Paclitaxel in Subjects With Head and Neck Cancer Unable for Cisplatin-based Chemotherapy (NIVOTAX) [Phase 2]
Phase 2 trial evaluating nivolumab plus paclitaxel for recurrent/metastatic head and neck squamous cell carcinoma in patients unable to rece…
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CLINICAL_TRIALS trial_result · 2025-06-13Clinical Trial Update: A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands [Phase 1]
Phase 1 clinical trial update of LGK974, a Wnt pathway inhibitor, in malignancies dependent on Wnt ligands; the study included several cance…
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CLINICAL_TRIALS trial_result · 2025-06-11Clinical Trial Update: Phase-2 Dacomitinib Study on Patients With EGFR-Driven Advanced Solid Tumours With Low EGFR-AS1 IncRNA Expr or Other Novel Emerging Biomarkers [Phase 2]
Phase-2 study of dacomitinib in EGFR-driven advanced solid tumours, including non-small cell lung cancer and head and neck squamous cell car…
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CLINICAL_TRIALS trial_result · 2025-06-11Clinical Trial Update: AVID100 in Advanced Epithelial Carcinomas [Phase 1, Phase 2]
A phase 1/2 trial of AVID100 for advanced epithelial carcinomas was terminated; results were posted in June 2025.
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Study of NKTR 255 in Combination With Cetuximab in Solid Tumors [Phase 1, Phase 2]
Phase 1/2 study evaluating NKTR-255 in combination with cetuximab in solid tumors, including head and neck squamous cell carcinoma and color…
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Trial Combining Pembrolizumab and Cesium 131 Brachytherapy With Salvage Surgery in HNSCC [Phase 1, Phase 2]
An ongoing Phase 1/Phase 2 trial evaluating pembrolizumab with Cesium-131 brachytherapy followed by salvage surgery for head and neck squamo…
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: REirradiation and Programmed Cell Death Protein 1 (PD-1) Blockade On Recurrent Squamous Cell Head and Neck Tumors [Phase 1, Phase 2]
This document reports the completion of a Phase 1/2 clinical trial assessing reirradiation with a PD-1 inhibitor in patients with recurrent …
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CLINICAL_TRIALS trial_result · 2025-05-31Clinical Trial Update: Real-time Margin Assessment in Head and Neck Cancer [Phase 2]
Phase 2 clinical trial update on a real-time margin assessment technique for head and neck cancer during surgery.
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: A Lithium-containing Mouthwash Prevention and Treatment of Oral Mucositis and Dysgeusia in Patients Undergoing Radiotherapy [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating a lithium-containing mouthwash to prevent and treat oral mucositis and dysgeusia in patients undergoin…
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CLINICAL_TRIALS trial_result · 2025-05-28Clinical Trial Update: Radiomics Model for Assessing Lymph Node Status in cN0 Patients withHNSCC
A completed clinical trial update describing a radiomics model designed to assess lymph node status in clinically node-negative head and nec…
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CLINICAL_TRIALS trial_result · 2025-05-25Clinical Trial Update: Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009) [Phase 2]
Phase 2 study LEAP-009 evaluated lenvatinib plus pembrolizumab versus standard chemotherapy and lenvatinib alone in recurrent/metastatic hea…
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CLINICAL_TRIALS trial_result · 2025-05-23Clinical Trial Update: A Study of NM21-1480 in Adult Patients With Advanced Solid Tumors [Phase 1, Phase 2]
A clinical trial update reports termination of the NM21-1480 study in adults with advanced solid tumors, including non-small cell lung cance…
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CLINICAL_TRIALS trial_result · 2025-05-22Clinical Trial Update: Neoadjuvant Chemotherapy, Tislelizumab With Afatinib for HNSCC [Phase 2]
Phase 2 neoadjuvant trial evaluating tislelizumab with afatinib for head and neck squamous cell carcinoma has completed status.
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CLINICAL_TRIALS trial_result · 2025-05-22Clinical Trial Update: Expression & Epigenetic Silencing of MicroRNA for Predicting Therapeutic Response and Prognosis of HPV-negative HNSCC
The clinical trial studied expression and epigenetic silencing of a microRNA as predictors of therapeutic response and prognosis in HPV-nega…
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CLINICAL_TRIALS trial_result · 2025-05-20Clinical Trial Update: A Study of JAB-3312 in Adult Patients With Advanced Solid Tumors in China [Phase 1]
The Phase 1 study of JAB-3312 in adults with advanced solid tumors in China has completed.
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: Durvalumab With or Without Metformin in Treating Participants With Head and Neck Squamous Cell Carcinoma [EARLY_Phase 1]
Early-phase 1 clinical trial evaluating durvalumab with or without metformin in head and neck squamous cell carcinoma, including oral cavity…
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: Pilot Study of Metformin in Head and Neck Squamous Cell Cancer and Its Effects on Stromal-epithelial Metabolic Uncoupling [EARLY_Phase 1]
A Phase 1 pilot trial studying metformin in head and neck squamous cell carcinoma and its effects on stromal-epithelial metabolic uncoupling…
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: Radiation Therapy and MK-3475 for Patients With Recurrent/Metastatic Head and Neck Cancer, Renal Cell Cancer, Melanoma, and Lung Cancer [Phase 1]
Phase 1 study evaluating the safety of combining radiation therapy with pembrolizumab (MK-3475) in patients with recurrent/metastatic head a…
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung Cancer
A completed clinical trial evaluating whether circulating tumor DNA can predict outcomes in patients with stage IV head and neck cancer or s…
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CLINICAL_TRIALS trial_result · 2025-05-13Clinical Trial Update: Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinoma [Phase 1]
This clinical trial update reports completion of a Phase 1 study evaluating lenvatinib in combination with cetuximab in patients with advanc…
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CLINICAL_TRIALS trial_result · 2025-05-11Clinical Trial Update: De-Escalation Therapy for Human Papillomavirus Negative Disease [Phase 2]
This clinical trial update reports Phase 2 results for de-escalation therapy in HPV-negative head and neck squamous cell carcinoma; results …
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CLINICAL_TRIALS trial_result · 2025-05-09Clinical Trial Update: A Study of Setanaxib Co-Administered With Pembrolizumab in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of Head and Neck (SCCHN) [Phase 2]
This document reports the completion of a Phase 2 trial evaluating Setanaxib co-administered with Pembrolizumab in recurrent or metastatic h…
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CLINICAL_TRIALS trial_result · 2025-05-09Clinical Trial Update: Study Comparing RT With Cetuximab + Xevinapant to RT With Cetuximab-placebo in Patients With Head and Neck Cancer [Phase 3]
A Phase 3 trial comparing radiotherapy with cetuximab plus Xevinapant versus radiotherapy with cetuximab plus placebo in head and neck squam…
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CLINICAL_TRIALS trial_result · 2025-05-08Clinical Trial Update: Paclitaxel Plus Cetuximab After First-line Checkpoint Inhibitor Failure [Phase 2]
Phase 2 trial evaluating paclitaxel plus cetuximab in head and neck squamous cell carcinoma after failure of first-line checkpoint inhibitor…
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CLINICAL_TRIALS trial_result · 2025-05-08Clinical Trial Update: A Trial of Durvalumab and Tremelimumab in Combination With SBRT in Patients With Metastatic Cancer [Phase 1, Phase 2]
This clinical trial update reports a completed Phase 1/2 study evaluating durvalumab in combination with tremelimumab and SBRT for metastati…