Head and Neck Squamous Cell Carcinoma
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CLINICAL_TRIALS trial_result · 2025-09-22Clinical Trial Update: A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With HNSCC (Master Protocol) (Pegathor Head and Neck 204) [Phase 2]
Phase 2 master protocol study evaluating SAR444245 in combination with other anticancer therapies for head and neck squamous cell carcinoma …
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CLINICAL_TRIALS trial_result · 2025-09-16Clinical Trial Update: FID-007 Followed by Standard of Care Surgery in Head and Neck Cancer [Phase 1]
Phase 1 trial of FID-007 followed by standard of care surgery for head and neck squamous cell carcinoma was terminated.
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CLINICAL_TRIALS trial_result · 2025-09-15Clinical Trial Update: A Phase 1/2 Study in Patients With HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Other Cancers [Phase 1, Phase 2]
This release reports the completion of a Phase 1/2 study of a HPV16-targeted immunotherapy in patients with HPV16+ recurrent/metastatic head…
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CLINICAL_TRIALS trial_result · 2025-09-09Clinical Trial Update: Effectiveness of an Enhanced Tobacco Intervention Protocol Compared to Standard Treatment in Helping Head and Neck and Lung Cancer Patients Starting Treatment to Reduce Cigarette Use [NA]
Completed clinical trial evaluating an enhanced tobacco intervention protocol versus standard treatment to reduce cigarette use in patients …
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CLINICAL_TRIALS trial_result · 2025-09-02Clinical Trial Update: Trial Evaluating Adapted Chemotherapy in Patients With Squamous Carcinoma [Phase 2]
A Phase 2 clinical trial evaluating adapted chemotherapy for head and neck squamous cell carcinoma has completed.
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CLINICAL_TRIALS trial_result · 2025-08-21Clinical Trial Update: Study of Cetuximab Plus/Minus Weekly Paclitaxel After Progression To First-Line Pembrolizumab Plus Platinum-5FU in Subjects With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck. [Phase 2]
This Phase 2 trial investigates cetuximab with or without weekly paclitaxel in patients with recurrent/metastatic head and neck squamous cel…
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CLINICAL_TRIALS trial_result · 2025-08-20Clinical Trial Update: Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689) [Phase 3]
This Phase 3 trial update covers pembrolizumab given before surgery and with post-surgical radiotherapy for advanced head and neck squamous …
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CLINICAL_TRIALS trial_result · 2025-08-17Clinical Trial Update: Pyrimethamine as an Inhibitor of NRF2 in HPV-unrelated Locally Advanced Head and Neck Squamous Cell Carcinoma [EARLY_Phase 1]
Completed early-phase 1 trial evaluating pyrimethamine as an NRF2 inhibitor in HPV-unrelated locally advanced head and neck squamous cell ca…
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CLINICAL_TRIALS trial_result · 2025-08-15Clinical Trial Update: Dose Escalation Study of mRNA-2752 for Intratumoral Injection to Participants in Advanced Malignancies [Phase 1]
Phase 1 dose-escalation and expansion study of intratumoral mRNA-2752 in advanced malignancies has completed, with expansion cohorts in seve…
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CLINICAL_TRIALS trial_result · 2025-08-15Clinical Trial Update: A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors [Phase 1, Phase 2]
A clinical trial update for SNS-101 (anti-VISTA) as monotherapy and in combination with cemiplimab in adults with advanced solid tumors, cur…
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CLINICAL_TRIALS trial_result · 2025-08-11Clinical Trial Update: A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors [EARLY_Phase 1]
Early-phase study update on intratumoral microdose administration of PBA-0405 in solid tumors; the trial status is completed.
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CLINICAL_TRIALS trial_result · 2025-08-07Clinical Trial Update: Phase 1, First-in-human, Dose-finding and Expansion Study to Evaluate XmAb®808 in Combination With Pembrolizumab in Advanced Solid Tumors [Phase 1]
Phase 1, first-in-human dose-finding and expansion study of XmAb808 in combination with pembrolizumab in advanced solid tumors; the trial ha…
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CLINICAL_TRIALS trial_result · 2025-08-07Clinical Trial Update: Oncolytic Adenovirus TILT-123 and Avelumab for Treatment of Solid Tumors Refractory to or Progressing After Anti-PD(L)1 [Phase 1]
Phase 1 trial evaluating the combination of oncolytic adenovirus TILT-123 with Avelumab in solid tumors that progressed after anti-PD-(L)1 t…
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CLINICAL_TRIALS trial_result · 2025-08-03Clinical Trial Update: Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04) [Phase 2]
A Phase 2 trial update (ASPEN-04) evaluating evorpacept in combination with pembrolizumab and chemotherapy for advanced head and neck squamo…
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CLINICAL_TRIALS trial_result · 2025-08-01Clinical Trial Update: TransCon (TC) TLR7/8 Agonist, TC IL-2 β/γ, Pembrolizumab Prior to Surgery for Advanced Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 trial evaluating TransCon TLR7/8 agonist, TransCon IL-2 beta/gamma, and pembrolizumab before surgery in advanced head and neck squam…
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CLINICAL_TRIALS trial_result · 2025-07-31Clinical Trial Update: Camrelizumab in Combination With Chemotherapy or Apatinib Mesylate as First-Line Treatment for R/M HNSCC [Phase 2]
A Phase 2 study evaluating camrelizumab in combination with chemotherapy or apatinib mesylate as first-line therapy for recurrent or metasta…
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CLINICAL_TRIALS trial_result · 2025-07-31Clinical Trial Update: MGC018 With or Without MGA012 in Advanced Solid Tumors [Phase 1, Phase 2]
This clinical trial update reports results from the combination of MGC018 with or without MGA012 (pembrolizumab) in advanced solid tumors. T…
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CLINICAL_TRIALS trial_result · 2025-07-31Clinical Trial Update: Neoadjuvant Tislelizumab With Afatinib for Resectable Head and Neck Squamous Cell Carcinoma [Phase 2]
This document reports a Phase 2 neoadjuvant trial evaluating the combination of tislelizumab and afatinib for resectable head and neck squam…
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CLINICAL_TRIALS trial_result · 2025-07-25Clinical Trial Update: IPI-549 in Patients With Locally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 clinical trial of IPI-549 in locally advanced HPV+ and HPV- head and neck squamous cell carcinoma has completed enrollment with resu…
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CLINICAL_TRIALS trial_result · 2025-07-18Clinical Trial Update: NUC-3373 in Combination With Other Agents in Patients With Advanced Solid Tumours [Phase 1, Phase 2]
NuCana plc announced termination of a Phase 1/2 trial evaluating NUC-3373 in combination with other agents for patients with advanced solid …
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CLINICAL_TRIALS trial_result · 2025-07-10Clinical Trial Update: 89Zr-girentuximab for PET Imaging of CAIX Positive Solid Tumors [Phase 2]
Telix's phase 2 trial of the CAIX-targeting PET tracer 89Zr-girentuximab in CAIX-positive solid tumors was terminated.
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CLINICAL_TRIALS trial_result · 2025-07-02Clinical Trial Update: A Study of Nivolumab in Patients With Head and Neck Cancer.
Clinical trial update noting the study of nivolumab in head and neck squamous cell carcinoma has completed.
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CLINICAL_TRIALS trial_result · 2025-07-01Clinical Trial Update: A Phase 1/2 Study of FS118 in Patients With Advanced Malignancies [Phase 1, Phase 2]
A Phase 1/2 study of FS118 in patients with advanced and metastatic cancers, including head and neck squamous cell carcinoma, has been termi…
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CLINICAL_TRIALS trial_result · 2025-07-01Clinical Trial Update: Pembrolizumab and Induction Chemotherapy in Locally Advanced HNSCC [Phase 2]
This clinical trial update reports a Phase 2 study evaluating pembrolizumab in combination with induction chemotherapy for locally advanced …
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CLINICAL_TRIALS trial_result · 2025-06-27Clinical Trial Update: Testing the Addition of M6620 (VX-970, Berzosertib) to Usual Chemotherapy and Radiation for Head and Neck Cancer [Phase 1]
Phase 1 trial evaluating the addition of M6620 (berzosertib; VX-970) to standard chemotherapy and radiation for head and neck cancers, inclu…