Head and Neck Squamous Cell Carcinoma
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CLINICAL_TRIALS trial_result · 2024-05-28Clinical Trial Update: Phase 1 Study of BAY1905254 - An Early Clinical Research Study to Evaluate a New Drug Called Bapotulimab (BAY1905254) in the Expansion Cohort in Combination With Pembrolizumab in Head and Neck Cancer That Has Returned or is Discovered to be Metastatic and is Expressing PDL1. [Phase 1]
Phase 1 expansion cohort study of Bapotulimab (BAY1905254) in combination with pembrolizumab in PD-L1–expressing head and neck squamous cell…
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CLINICAL_TRIALS trial_result · 2024-05-24Clinical Trial Update: Hearing Loss and the Effects of Statin Drugs in People With Head and Neck Squamous Cell Carcinoma Treated With Cisplatin Chemoradiation
A completed clinical trial from NIDCD examined whether statin therapy influences hearing loss in patients with head and neck squamous cell c…
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CLINICAL_TRIALS trial_result · 2024-05-14Clinical Trial Update: PBI-MST-01 (NCT04541108) Substudy MSD-03: Intratumoral Microdosing of Pembrolizumab Alone and With MK-0482 or MK-4830 in HNSCC or STS [EARLY_Phase 1]
An early-phase trial evaluating intratumoral microdosing of pembrolizumab alone or with MK-0482 or MK-4830 in head and neck squamous cell ca…
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CLINICAL_TRIALS trial_result · 2024-05-14Clinical Trial Update: Standard and Delayed FDG PET/CT After Chemoradiation Therapy in Assessing Patients With Metastatic Head and Neck Squamous Cell Cancer [NA]
Clinical trial update noting an evaluation of standard and delayed FDG PET/CT after chemoradiation in patients with metastatic head and neck…
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CLINICAL_TRIALS trial_result · 2024-05-09Clinical Trial Update: A Study of Pembrolizumab (MK-3475) Plus Carboplatin and Paclitaxel as First-line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (MK-3475-B10/KEYNOTE B10) [Phase 4]
Phase 4 trial MK-3475-B10 (KEYNOTE B10) evaluating pembrolizumab with carboplatin and paclitaxel as first-line therapy for recurrent/metasta…
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CLINICAL_TRIALS trial_result · 2024-05-08Clinical Trial Update: EACH: Evaluating Avelumab in Combination With Cetuximab in Head and Neck Cancer [Phase 2]
This is a Phase 2 trial update evaluating the combination of avelumab and cetuximab for head and neck squamous cell carcinoma, sponsored by …
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CLINICAL_TRIALS trial_result · 2024-05-06Clinical Trial Update: Comparison of Concomitant Cisplatin Versus Carboplatin and 5-fluorouracil With Radiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma
A completed clinical trial comparing concomitant cisplatin versus carboplatin plus 5-fluorouracil with radiotherapy in locally advanced head…
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CLINICAL_TRIALS trial_result · 2024-05-02Clinical Trial Update: P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC [Phase 2]
A Phase 2 clinical trial evaluating P53 mutational status and circulating cell-free HPV DNA as biomarkers to guide management of HPV-associa…
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CLINICAL_TRIALS trial_result · 2024-04-15Clinical Trial Update: Study to Evaluate Safety and Efficacy of TJ107 Combine With PD-1 in Patients With Solid Tumors [Phase 2]
Phase 2 trial evaluating safety and efficacy of TJ107 combined with PD-1 in patients with solid tumors, including triple-negative breast can…
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CLINICAL_TRIALS trial_result · 2024-04-11Clinical Trial Update: Radiotherapy With Double Checkpoint Blockade of Locally Advanced HNSCC [Phase 2]
Phase 2 trial update on radiotherapy with double checkpoint blockade for locally advanced head and neck squamous cell carcinoma has complete…
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CLINICAL_TRIALS trial_result · 2024-04-04Clinical Trial Update: Bempegaldesleukin (NKTR-214) With Radiation and Anti-PD-1 Immunotherapy for Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 trial evaluating bempegaldesleukin (NKTR-214) with radiation and anti-PD-1 for head and neck squamous cell carcinoma was terminated;…
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CLINICAL_TRIALS trial_result · 2024-04-01Clinical Trial Update: Nivolumab, Carboplatin, and Paclitaxel in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery [Phase 2]
A phase 2 trial evaluated the combination of nivolumab with carboplatin and paclitaxel in patients with stage III-IV head and neck squamous …
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CLINICAL_TRIALS trial_result · 2024-03-15Clinical Trial Update: Palbociclib With Cetuximab and IMRT for Locally Advanced Squamous Cell Carcinoma [Phase 1, Phase 2]
Clinical trial update on palbociclib combined with cetuximab and IMRT for locally advanced head and neck squamous cell carcinoma (phases 1 a…
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CLINICAL_TRIALS trial_result · 2024-03-08Clinical Trial Update: A Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastatic Solid Tumors [Phase 1, Phase 2]
A safety and tolerability study of NC318 in advanced or metastatic solid tumors completed Phase 1/2 with results posted in 2024.
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CLINICAL_TRIALS trial_result · 2024-02-14Clinical Trial Update: Bevacizumab/Ph 2 for Locally Advanced Head and Neck Cancer [Phase 2]
Phase 2 trial update evaluating bevacizumab in locally advanced head and neck squamous cell carcinoma; completed with results posted.
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CLINICAL_TRIALS trial_result · 2024-02-09Clinical Trial Update: Phase III Trial Comparing Methotrexate and Cetuximab in First-line Treatment of Recurrent and/or Metastatic Squamous Cell Head and Neck Cancer [Phase 3]
Phase 3 trial comparing methotrexate versus cetuximab in first-line treatment of recurrent/metastatic squamous cell carcinoma of the head an…
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CLINICAL_TRIALS trial_result · 2024-02-05Clinical Trial Update: Streptococcus Salivarius K12 for Prevention and Treatment of Oral Mucositis in Patients Undergoing Radiotherapy [Phase 2]
Phase 2 trial update evaluating Streptococcus Salivarius K12 for prevention and treatment of oral mucositis in patients undergoing radiother…
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CLINICAL_TRIALS trial_result · 2024-02-01Clinical Trial Update: Neoadjuvant Tislelizumab Plus Chemotherapy for Resectable Locally-advanced Head and Neck Squamous Cell Carcinoma [Phase 2]
A Phase 2 clinical trial evaluating neoadjuvant tislelizumab in combination with chemotherapy for resectable locally-advanced head and neck …
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CLINICAL_TRIALS trial_result · 2024-01-30Clinical Trial Update: Vaccination With Flt3L, Radiation, and Poly-ICLC [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating vaccination with Flt3L, radiation, and Poly-ICLC in cancer patients.
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CLINICAL_TRIALS trial_result · 2024-01-23Clinical Trial Update: Envafolimab Combined With Chemotherapy in Neoadjuvant and Conversion Therapy for Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 trial exploring Envafolimab plus chemotherapy as neoadjuvant and conversion therapy for head and neck squamous cell carcinoma.
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CLINICAL_TRIALS trial_result · 2024-01-10Clinical Trial Update: Targeting PD-1 Therapy Resistance With Focused High or High and Low Dose Radiation in SCCHN [Phase 2]
Phase 2 trial results evaluate whether adding focused high-dose radiation to PD-1–directed therapy can overcome resistance in head and neck …
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CLINICAL_TRIALS trial_result · 2024-01-09Clinical Trial Update: Study of Post-Op Adjuvant Concurrent Chemo-RT With or Without Nimotuzumab for Head & Neck Cancer [Phase 3]
Phase 3 study evaluating post-operative adjuvant concurrent chemoradiotherapy with or without nimotuzumab for head and neck squamous cell ca…
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CLINICAL_TRIALS trial_result · 2023-12-20Clinical Trial Update: Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer [Phase 2]
Phase 2 trial evaluating enoblituzumab in combination with retifanlimab or tebotolimab in head and neck cancer was terminated, with results …
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CLINICAL_TRIALS trial_result · 2023-12-20Clinical Trial Update: Advanced First-line Treatment of Short-term Postoperative Progression of Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 clinical trial update for advanced first-line treatment of short-term postoperative progression in head and neck squamous cell carci…
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CLINICAL_TRIALS trial_result · 2023-12-08Clinical Trial Update: Durvalumab (MEDI4736) With Cetuximab in Previously Treated Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 clinical trial evaluating durvalumab with cetuximab in previously treated recurrent or metastatic head and neck squamous cell carcin…