Head and Neck Squamous Cell Carcinoma
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CLINICAL_TRIALS research · 2026-01-02Clinical Trial Update: Optimised Early Management of Squamous Cell Carcinoma of the Head and Neck Cancer [NA]
A clinical trial investigating optimized early management of head and neck squamous cell carcinoma is currently recruiting.
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CLINICAL_TRIALS research · 2025-12-31Clinical Trial Update: A Study of BL-M24D1 in Patients With Locally Advanced or Metastatic Head and Neck Squamous Cell Carcinoma and Other Solid Tumors [Phase 1]
BL-M24D1 is being studied in a Phase 1 trial for locally advanced or metastatic head and neck squamous cell carcinoma and other solid tumors…
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: Nab-Paclitaxel in Combination With Nivolumab to Treat Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma That Progressed on a PD-1 or PD-L1 Inhibitor [Phase 2]
This is a Phase 2 clinical trial update evaluating the combination of nab-paclitaxel and nivolumab in recurrent or metastatic head and neck …
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: Sintilimab-Nimotuzumab Induction Followed by Chemoradiation-Nimotuzumab in LA-HNSCC: Single-Arm Phase II [Phase 2]
Phase II, single-arm clinical trial evaluating induction with Sintilimab and Nimotuzumab followed by Nimotuzumab-containing chemoradiation i…
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: Ramucirumab + Pembrolizumab in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma [Phase 1, Phase 2]
Clinical trial update on the combination of ramucirumab and pembrolizumab for recurrent/metastatic head and neck squamous cell carcinoma in …
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: Impact of Patient-Reported Outcomes for Symptom Monitoring in Patients Followed for Head and Neck Squamous Cell Carcinoma (HNSCC) [NA]
This entry describes an ongoing clinical trial evaluating the impact of patient-reported outcomes for symptom monitoring in patients with he…
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: Validation of Molecular Diagnostic Assays to Detect Cancer Biomarkers in Blood and Primary Tumor in HNSCC/NSCLC/Melanoma
A clinical trial update describing validation of molecular diagnostic assays that detect cancer biomarkers in blood and primary tumors. The …
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: A Clinical Trial Comparing Low-Dose RT + Targeted Therapy+ Immunotherapy vs Targeted Therapy+ Immunotherapy Alone as Neoadjuvant Therapy in Operable HNSCC Patients. [Phase 2]
A Phase 2 trial in operable Head and Neck Squamous Cell Carcinoma compares low-dose radiotherapy plus targeted therapy and immunotherapy ver…
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CLINICAL_TRIALS research · 2025-12-26Clinical Trial Update: Comparison of 89Zr Panitumumab and (18)F-Fluorodeoxyglucose to Identify Head and Neck Squamous Cell Carcinoma [EARLY_Phase 1]
An early-phase clinical trial compares 89Zr-labeled panitumumab with FDG-PET imaging to help identify head and neck squamous cell carcinoma …
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CLINICAL_TRIALS research · 2025-12-23Clinical Trial Update: Carboplatin + Paclitaxel + Cetuximab (PCC) After Failure of Pembrolizumab +/- First-line Chemotherapy in Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck [Phase 2]
A Phase 2 clinical trial evaluating carboplatin, paclitaxel, and cetuximab for recurrent/metastatic head and neck squamous cell carcinoma af…
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: Thermotherapy in Addition to SOC Palliative Radiotherapy [NA]
A clinical trial update indicating recruitment for a study evaluating thermotherapy added to standard of care palliative radiotherapy in pat…
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CLINICAL_TRIALS research · 2025-12-19Clinical Trial Update: (89Zr Panitumumab) With PET/CT for Diagnosing Metastases in Patients With Head and Neck Squamous Cell Carcinoma [Phase 1]
Phase 1 clinical trial evaluating 89Zr-labeled panitumumab with PET/CT for diagnosing metastases in head and neck squamous cell carcinoma; c…
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CLINICAL_TRIALS research · 2025-12-19Clinical Trial Update: Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients [Phase 2]
Ongoing Phase 2 clinical trial evaluating pembrolizumab in combination with metformin for metastatic head and neck squamous cell carcinoma; …
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Neoadjuvant Targeting of Myeloid Cell Populations in Combination With Nivolumab in Head & Neck Ca [Phase 2]
Phase 2 neoadjuvant trial combining targeting of myeloid cell populations with Nivolumab in head and neck squamous cell carcinoma is current…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Methylnatrexone In Resectable Head and Neck Squamous Cell Carcinoma (MINK). A "Window of Opportunity" Pilot Study. [Phase 4]
A Phase 4 window-of-opportunity pilot trial evaluating methylnatrexone in resectable head and neck squamous cell carcinoma is currently recr…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Sorafenib in Combination With Carboplatin and Paclitaxel in Treating Participants With Metastatic or Recurrent Head and Neck Squamous Cell Cancer [Phase 2]
This clinical trial update describes a Phase 2 study of sorafenib in combination with carboplatin and paclitaxel for metastatic or recurrent…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Tumor-Informed ctDNA Testing for MRD Following Treatment of Squamous Cell Carcinoma
Clinical trial update on tumor-informed ctDNA testing for minimal residual disease after treatment in head and neck squamous cell carcinoma …
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CLINICAL_TRIALS research · 2025-12-11Clinical Trial Update: A Study of MT-4561 in Patients With Various Advanced Solid Tumors [Phase 1, Phase 2]
This trial update reports that MT-4561 is being studied in multiple advanced solid tumors across Phase 1/Phase 2 and is currently recruiting…
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CLINICAL_TRIALS research · 2025-12-05Clinical Trial Update: Tirellizumab Combined With TP Neoadjuvant Therapy in the Treatment of Early Oral Squamous Cell Carcinoma （HNC-SYSU-005） [Phase 2]
Phase 2 clinical trial update on Tirellizumab in combination with TP neoadjuvant therapy for early oral squamous cell carcinoma, currently a…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program [Phase 2]
Phase 2 trial evaluating in-home versus in-clinic subcutaneous nivolumab administration under the CC Beyond Walls program; the study is curr…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Study of GV20-0251 in Participants With Solid Tumor Malignancies [Phase 1, Phase 2]
GV20 Therapeutics is evaluating GV20-0251 in a Phase 1/2 trial for adults with various solid tumors, and the study is currently recruiting. …
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC [Phase 1]
A Phase 1 dose-finding study evaluating Zanzalintinib in combination with pembrolizumab and cetuximab for head and neck squamous cell carcin…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Naptumomab Estafenatox in Combination With Durvalumab in Subjects With Selected Advanced or Metastatic Solid Tumor, Including a Cohort Expansion in Esophageal Cancer. [Phase 1]
Phase 1 trial update of Naptumomab Estafenatox in combination with durvalumab in selected advanced or metastatic solid tumors, including eso…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: A Study of YL202 in Selected Patients With Advanced Solid Tumors [Phase 2]
Phase 2 study of YL202 in selected patients with advanced solid tumors including non-small cell lung cancer, breast cancer, and head and nec…
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CLINICAL_TRIALS research · 2025-11-25Clinical Trial Update: Ivonescimab Before Surgery for the Treatment of Resectable Stage II-IV Head and Neck Cancer [Phase 2]
A Phase 2 clinical trial is evaluating Ivonescimab given before surgery in patients with resectable stage II-IV head and neck squamous cell …