Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: Toripalimab ± Chemo as Neoadjuvant Therapy in LA-HNSCC: A Phase III Trial [Phase 3]
A Phase III clinical trial is planned to evaluate toripalimab with or without chemotherapy as neoadjuvant therapy for locally advanced head …
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: Comparison of Efficacy Between De-escalated Surgery and Standard Surgery After Neoadjuvant Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma [NA]
A clinical trial comparing de-escalated surgery to standard surgery after neoadjuvant immunotherapy in locally advanced head and neck squamo…
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CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers [EARLY_Phase 1]
An early-phase 1 trial at Brigham and Women's Hospital is screening a novel IMD drug in patients with salivary gland cancers and head and ne…
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CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: SYS6010 Combined With Enlonstobart In Recurrent Or Metastatic Head And Neck Squamous Cell Carcinoma [Phase 2]
A Phase 2 clinical trial update assessing SYS6010 in combination with Enlonstobart for recurrent or metastatic head and neck squamous cell c…
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CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer [Phase 1]
Phase 1 clinical trial evaluating decitabine in combination with standard-of-care therapy for surgically resectable HPV-negative head and ne…
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CLINICAL_TRIALS research · 2026-01-23Clinical Trial Update: Study to Evaluate the Safety and Efficacy of Oral NRC-2694-A in Combination With Paclitaxel in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma, Who Progressed on or After Immune Checkpoint Inhibitor Therapy [Phase 2]
A Phase 2 clinical trial is evaluating safety and efficacy of oral NRC-2694-A in combination with paclitaxel for recurrent and/or metastatic…
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CLINICAL_TRIALS research · 2026-01-23Clinical Trial Update: Intensive Symptom Surveillance Guided by Machine Learning-Directed Risk Stratification in Patients With Non-Metastatic Head and Neck Cancer, The INSIGHT Trial [NA]
Clinical trial update for the INSIGHT trial using machine-learning-directed risk stratification to guide intensive symptom surveillance in n…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: First in Human Study of QLS5316 in Solid Tumors [Phase 1]
This is a first-in-human Phase 1 trial of QLS5316 in various solid tumors; the study is not yet recruiting.
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer [Phase 1]
A Phase 1 clinical trial update examining multiple drug combinations including BI 765063, Ezabenlimab, Cetuximab, and BI 836880 for head and…
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: A Single-Arm Phase II Clinical Study of Docetaxel Combined With Nimotuzumab and Pucotenlimab as Second-Line and Beyond Therapy for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma [Phase 2]
A single-arm Phase II clinical trial evaluating docetaxel combined with nimotuzumab and pucotenlimab as second-line and beyond therapy for r…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: A Study of HB-202/HB-201 in People With Human Papilloma Virus 16-Positive Head and Neck Squamous Cell Cancer (HPV 16+ HNSCC) [EARLY_Phase 1]
Clinical trial update describes an early-phase (Phase 1) study of HB-202 and HB-201 in HPV16-positive head and neck squamous cell carcinoma;…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: SBRT +/- Pembrolizumab in Patients With Local-Regionally Recurrent or Second Primary Head and Neck Carcinoma [Phase 2]
A Phase 2 clinical trial is evaluating stereotactic body radiotherapy with or without pembrolizumab for local-regionally recurrent or second…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: A Trial of Locoregionally Advanced Squamous Cell Carcinoma of The Head and Neck [Phase 2]
Phase 2 clinical trial exploring locoregionally advanced head and neck squamous cell carcinoma, currently not yet recruiting.
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer [Phase 1]
Phase 1 trial evaluating intratumoral delivery of saRNA particles expressing IL-12 for head and neck cancers is currently recruiting.
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400 [Phase 1]
Phase 1 study assessing adverse events and change in disease activity in adults with select advanced solid tumors treated with ABBV-400; the…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Postoperative Radiotherapy for Intermediate- and High-risk Patients With HNSCC Greater Than 6 Weeks After Surgery [NA]
A Wake Forest trial is evaluating postoperative radiotherapy for intermediate- and high-risk head and neck squamous cell carcinoma patients …
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: Clinical Trial of SIBP-03 in Patients With Head and Neck Squamous Cell Carcinoma [Phase 2]
An ongoing Phase 2 clinical trial evaluating SIBP-03 for head and neck squamous cell carcinoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-01-14Clinical Trial Update: QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors [Phase 2]
ClinicalTrials.gov update for QUILT-3.055, a Phase 2 study of combination immunotherapies in patients who previously received immune checkpo…
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: Neoadjuvant Chemotherapytreatment of Locally Advanced Head and Neck Squamous Cell Carcinoma [Phase 2]
An ongoing Phase 2 neoadjuvant chemotherapy trial for locally advanced head and neck squamous cell carcinoma is active but not recruiting.
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: Stereotactic Post-operative Radiotherapy for Intraparotid Metastatic Cutaneous Squamous Cell Carcinoma [NA]
A clinical study evaluating stereotactic post-operative radiotherapy for intraparotid metastatic cutaneous squamous cell carcinoma is curren…
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: Study of DECOY20 With or Without Tislelizumab in Patients With Advanced Solid Tumors [Phase 1, Phase 2]
Clinical trial update for DECOY20 with or without tislelizumab in adults with advanced solid tumors across Phase 1 and Phase 2. The listed i…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: 5-Azacytidine and/or Nivolumab in Resectable HPV-Associated HNSCC [Phase 2]
Phase 2 clinical trial evaluating the combination of 5-Azacytidine and/or Nivolumab in patients with resectable HPV-associated head and neck…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: Compare Radiotherapy Plus Nimotuzumab Versus Radiotherapy Alone in Platinum-ineligible Patients With Locoregionally Advanced Head and Neck Squamous Cell Carcinoma [Phase 3]
A Phase 3 clinical trial is investigating radiotherapy plus nimotuzumab versus radiotherapy alone in platinum-ineligible locoregionally adva…
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CLINICAL_TRIALS research · 2026-01-08Clinical Trial Update: Adoptive Cell Therapy Using Cancer Specific CD8+ Tumor Infiltrating Lymphocytes in Adult Patients With Solid Tumors [Phase 1]
A Phase 1 clinical trial from AgonOx is evaluating cancer-specific CD8+ TIL-based adoptive cell therapy in adults with solid tumors, includi…
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas [Phase 1]
DR-0202 is being studied in a Phase 1 trial across multiple locally advanced or metastatic carcinomas; the study is currently recruiting.