Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Study Comparing Ivonescimab Alone or Ivonescimab in Combination With Ligufalimab Versus Pembrolizumab for the Treatment of SCCHN [Phase 3]
A Phase 3 clinical trial compares Ivonescimab alone or Ivonescimab with Ligufalimab versus Pembrolizumab for head and neck squamous cell car…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: A Study to Learn About the Study Medicine Called PF-08046032 in People With Advanced Cancers [Phase 1]
Phase 1 clinical trial update for PF-08046032 in people with advanced cancers; the study is currently active but not recruiting.
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC [Phase 2]
Phase 2 clinical trial evaluating adaptive radiotherapy boost for head and neck squamous cell carcinoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: TBio-4101 and Pembro wi/ or w/o Chemo in Recurrent/Metastatic HNSCC [Phase 1]
A Phase 1 clinical trial update for TBio-4101 with pembrolizumab, with or without chemotherapy, in recurrent or metastatic head and neck squ…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types [Phase 1]
IDEAYA Biosciences is conducting a Phase 1 study of IDE034 in adults with multiple locally advanced or metastatic solid tumors; the trial is…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Neoadjuvant Sacituzumab Govitecan Plus Tagitanlimab for Resectable Head and Neck Squamous Cell Carcinoma [Phase 2]
A Phase 2 neoadjuvant trial is evaluating sacituzumab govitecan in combination with Tagitanlimab for resectable head and neck squamous cell …
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients [Phase 3]
This update describes a Phase 3 trial evaluating Petosemtamab versus investigator's choice monotherapy in previously treated head and neck s…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: A Study to Assess IPN01194 When Administered Alone in Adults With Advanced Solid Tumours [Phase 1, Phase 2]
Ipsen is conducting a Phase 1/2 trial of IPN01194 as a single-agent therapy for adults with advanced solid tumors, currently recruiting.
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: INBRX-106 in Combination With Pembrolizumab in First-line PD-L1 CPS≥20 HNSCC [Phase 2, Phase 3]
Ongoing Phase 2/Phase 3 trial evaluating INBRX-106 in combination with pembrolizumab as first-line therapy for PD-L1 CPS≥20 head and neck sq…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Multicentric Comparative Study Between a Conventional and an Intensive Follow up Strategy After Treatment of a Head and Neck Squamous Cell Carcinoma [Phase 3]
Phase 3 multicenter trial comparing conventional versus intensive follow-up after treatment of head and neck squamous cell carcinoma; curren…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer [Phase 1]
This clinical trial update notes a Phase 1 study evaluating cemiplimab in combination with chemotherapy and immunotherapy for head and neck …
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Pilot Study of [68Ga]Ga-ABY-025 Imaging in Patients Undergoing Treatment With HER2-targeted Therapy [EARLY_Phase 1]
This is a pilot early-phase imaging trial evaluating the HER2-targeted PET tracer [68Ga]Ga-ABY-025 in patients undergoing HER2-targeted ther…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: 177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors [Phase 1, Phase 2]
This clinical trial update describes ongoing Phase 1/2 studies of the radiopharmaceutical 177Lu-BetaBart. The trial is evaluating its use in…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Neoadjuvant Ficerafusp Alfa With Pembrolizumab in Resectable SCC [Phase 2]
Phase 2 neoadjuvant trial evaluating ficerafusp alfa with pembrolizumab in resectable head and neck squamous cell carcinoma is currently rec…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer [Phase 2]
Phase II trial evaluating neoadjuvant chemotherapy alone or with the PRGN-2009 immunotherapy vaccine for newly diagnosed HPV-associated orop…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: GV20-0251 and Sintilimab for Neoadjuvant Treatment of Resectable Head and Neck Squamous Cell Carcinoma: A Single-Arm Study [Phase 1]
A Phase 1, single-arm neoadjuvant study evaluating GV20-0251 in combination with Sintilimab for patients with resectable head and neck squam…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC [Phase 1]
A Phase 1 clinical trial update for EPI-326 in EGFR-mutant non-small cell lung cancer and head and neck squamous cell carcinoma; the study i…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Nano-Carbon Iron Suspension Injection Combined With Radiotherapy for Solid Tumors Phase II Clinical Trial [Phase 2]
This is a Phase II clinical trial evaluating Nano-Carbon Iron Suspension Injection in combination with radiotherapy for solid tumors. The st…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: First Line Weekly Chemo/Immunotherapy for Metastatic Head/Neck Squamous Cell Carcinoma Patients [Phase 2]
Phase 2 trial evaluating first-line weekly chemotherapy combined with immunotherapy for metastatic head and neck squamous cell carcinoma; th…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors [Phase 2]
A Phase 2 clinical trial evaluating Volrustomig as monotherapy or in combination with anti-cancer agents across multiple advanced/metastatic…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: A Phase 1/1b of RNDO-564 Single Agent or in Combination With Pembrolizumab in Bladder Cancer and Other Solid Tumors Associated With Nectin-4 [Phase 1]
Phase 1/1b trial evaluating RNDO-564 as a single agent or in combination with pembrolizumab in bladder cancer and nectin-4–associated solid …
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV [Phase 1]
This is a Phase 1 clinical trial evaluating the combination of cabozantinib (XL184) and nivolumab in patients with various advanced cancers …
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Comparing Postoperative Adjuvant Cisplatin Concurrent Chemoradiotherapy With Adjuvant Radiotherapy Alone for Intermediate-risk Head and Neck Squamous Cell Carcinoma [Phase 3]
Phase 3 clinical trial evaluating whether postoperative adjuvant cisplatin-based chemoradiotherapy improves outcomes compared with adjuvant …
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC [Phase 2, Phase 3]
FORTIFI-HN01 is a Phase 2/3 trial evaluating Ficerafusp Alfa (BCA101) with pembrolizumab versus placebo with pembrolizumab in first-line PD-…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 clinical trial evaluating whether combining Fianlimab with Cemiplimab improves treatment of recurrent or metastatic head and neck sq…