Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: The SWOAR Trial Sparing of Swallowing and Aspiration Related Organs at Risk & Submandibular Gland With Intensity Modulated Radiotherapy Versus Standard IMRT in Head and Neck Squamous Cell Carcinomas [Phase 3]
A Phase 3 trial update describing SWOAR-sparing IMRT compared with standard IMRT for head and neck squamous cell carcinoma; currently not re…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: CUE-101with Pembrolizumab for LA-HPV+HNSCCs [Phase 2]
This ClinicalTrials.gov entry describes a Phase 2 trial evaluating CUE-101 in combination with Pembrolizumab for locally advanced, HPV-posit…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma [Phase 1, Phase 2]
A Phase 1/2 clinical trial update describes evaluating PD-1 inhibition with neoadjuvant proton or photon radiation therapy for recurrent hea…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1 [Phase 2, Phase 3]
A Phase 2/3 clinical trial is evaluating BNT113 in combination with pembrolizumab versus pembrolizumab alone for HPV16-positive, PD-L1-expre…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Study of XB010 in Subjects With Solid Tumors [Phase 1]
A Phase 1 trial evaluating XB010 in locally advanced or metastatic solid tumors is currently recruiting across multiple indications.
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Phase Ib/II Study of an Anti-HER3 Antibody, HMBD-001, With Cetuximab +/- Docetaxel in Advanced Squamous Cell Cancers [Phase 1, Phase 2]
A Phase Ib/II clinical trial evaluating HMBD-001, an anti-HER3 antibody, in combination with cetuximab with or without docetaxel for advance…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors [Phase 1]
Phase 1 clinical trial evaluating IACS-6274 with or without Bevacizumab and Paclitaxel in adults with advanced solid tumors; the study is cu…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors [Phase 1]
Phase 1 clinical trial update for Enzelkitug as a single agent and in combination with a checkpoint inhibitor in adults with locally advance…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation [Phase 1]
NT-175 is being studied in a Phase 1 trial enrolling adults with unresectable, advanced, or metastatic solid tumors positive for HLA-A*02:01…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Study to Test Whether Treatment With BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Helps People With Head and Neck Cancer Compared With Pembrolizumab Alone [Phase 1]
A Phase 1 clinical trial is evaluating BI 770371 in combination with pembrolizumab, with or without cetuximab, versus pembrolizumab alone in…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Blood Tests and Questionnaires in Studying Adherence to Preventative Swallowing Exercises in Participants With Metastatic Head and Neck Cancer
This clinical trial update describes the use of blood tests and questionnaires to study adherence to preventative swallowing exercises in pa…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY) [Phase 2]
A Phase 2a, single-dose, open-label study evaluating Pegsitacianine for intraoperative fluorescence imaging to detect cancer in patients wit…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Phase II Study of Ficerafusp Alfa in Combination With Nivolumab in Patients With Platinum-refractory Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase II trial update on Ficerafusp Alfa in combination with Nivolumab for platinum-refractory head and neck squamous cell carcinoma; the st…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study [Phase 2]
A Phase 2 immunoMATCH pilot trial (BiCaZO) is evaluating cabozantinib in combination with nivolumab for advanced melanoma and head and neck …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors [Phase 1]
Phase 1 study of LY4101174 in participants with recurrent, advanced or metastatic solid tumors is currently active but not recruiting.
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer [Phase 2]
A Phase 2 clinical trial is testing adding chemotherapy or chemo-immunotherapy to standard surgery for advanced head and neck cancers, inclu…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer [Phase 3]
Phase 3 clinical trial evaluating amivantamab added to standard of care versus standard of care alone in recurrent/metastatic head and neck …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Becotatug Vedotin (MRG003) in Combination With PD-1 Inhibitor Versus PD-1 Inhibitor for the Treatment of EGFR-positive, CPS≥1 Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma [Phase 3]
Phase 3 trial update of Becotatug Vedotin (MRG003) in combination with a PD-1 inhibitor for EGFR-positive CPS≥1 resectable locally advanced …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: GB1211 and Pembrolizumab Versus Pembrolizumab and Placebo in Patients With Metastatic Melanoma and Head and Neck Squamous Cell Carcinoma [Phase 2]
A Phase 2 clinical trial is evaluating GB1211 in combination with pembrolizumab versus pembrolizumab with placebo in patients with metastati…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Phase Ib Trial of Multivalent Autophagosome Vaccine With or Without GITR Agonist, With Anti-PD-1 Immunotherapy in HNSCC [Phase 1]
Phase Ib trial of a multivalent autophagosome vaccine with or without a GITR agonist, combined with anti-PD-1 immunotherapy, for head and ne…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma [Phase 1]
A Phase 1 study evaluating JNJ-90301900 in combination with chemoradiation therapy for locally advanced head and neck squamous cell carcinom…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan [Phase 1]
Phase 1 trial evaluating the safety, adverse events, and pharmacokinetics of Azirkitug alone or in combination with Budigalimab, Bevacizumab…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer [Phase 1, Phase 2]
A Phase 1/Phase 2 study of amivantamab, alone or in combination with other agents, for head and neck squamous cell carcinoma is currently re…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Window of Opportunity in Preserving Laryngeal Function Trial [Phase 2]
A Phase 2 clinical trial update indicates recruitment is ongoing for a window-of-opportunity study aimed at preserving laryngeal function in…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Addition of an Anti-cancer Drug, Ipatasertib, to the Usual Immunotherapy Treatment (Pembrolizumab) in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck [Phase 2]
A Phase 2 clinical trial is exploring adding ipatasertib to pembrolizumab in patients with recurrent or metastatic head and neck squamous ce…