Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-08-27Clinical Trial Update: SYS6002 Plus JMT101 and Enlonstobart Injection in Participants With HNSCC [Phase 2]
A Phase 2 clinical trial evaluating the combination of SYS6002 with JMT101 and Enlonstobart Injection in participants with head and neck squ…
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CLINICAL_TRIALS research · 2025-08-20Clinical Trial Update: Pembrolizumab in Combination With Low-dose PFas Neoadjuvant Treatment for Locally Advanced HNSCC [Phase 2]
A Phase 2 clinical trial evaluating pembrolizumab in combination with low-dose PFas neoadjuvant treatment for locally advanced head and neck…
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CLINICAL_TRIALS research · 2025-08-20Clinical Trial Update: Immune Response in Cervical Lymph Nodes of Patients With Head and Neck Cancer
This clinical trial update describes a study evaluating immune responses in cervical lymph nodes of patients with head and neck squamous cel…
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CLINICAL_TRIALS research · 2025-08-17Clinical Trial Update: Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma [Phase 2, Phase 3]
Clinical trial update on a phase 2/3 study comparing Zanzalintinib (XL092) plus pembrolizumab to pembrolizumab alone in PD-L1-positive recur…
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CLINICAL_TRIALS research · 2025-08-15Clinical Trial Update: Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors [Phase 1]
Phase 1 study evaluating safety and tolerability of BCA101 as monotherapy and in combination in EGFR-driven advanced solid tumors. The trial…
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: 2 Courses of Concurrent Cisplatin Chemoradiotherapy After Surgery for High-risk Head and Neck Squamous Cell Carcinoma [Phase 3]
A Phase 3 trial evaluating two courses of concurrent cisplatin chemoradiotherapy after surgery for high-risk head and neck squamous cell car…
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CLINICAL_TRIALS research · 2025-08-12Clinical Trial Update: Establishment of Squamous Cell Organoids of the Head and Neck to Assess Their Response to Innovative Therapies
The study aims to establish organoids from head and neck squamous cell carcinoma to assess their response to innovative therapies.
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CLINICAL_TRIALS research · 2025-08-11Clinical Trial Update: A Phase 0 Multicenter Study of the Pharmacodynamic Effects of Intratumoral Microdose Administration of PBA-0111 in Patients With Solid Tumors [EARLY_Phase 1]
Phase 0 multicenter study evaluating pharmacodynamic effects of intratumoral microdosing with PBA-0111 in solid tumors; the trial is current…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: A Study of Nimotuzumab Plus Adebrelimab With Chemotherapy in Cisplatin-Ineligible Patients With Head And Neck Squamous Cell Carcinoma [Phase 1, Phase 2]
A clinical trial update describes an ongoing Phase 1/2 study of nimotuzumab plus adebrelimab with chemotherapy in cisplatin-ineligible patie…
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CLINICAL_TRIALS research · 2025-08-01Clinical Trial Update: Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03) [Phase 2]
A Phase 2 clinical trial ASPEN-03 evaluating Evorpacept (ALX148) in combination with pembrolizumab for advanced head and neck squamous cell …
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CLINICAL_TRIALS research · 2025-07-31Clinical Trial Update: Neoadjuvant and Adjuvant Toripalimab and Cetuximab in Patients With Recurrent, Resectable Squamous Cell Carcinoma of Head and Neck: a Prospective, Single-arm,Phase II Study [Phase 2]
This ClinicalTrials.gov update describes a Phase 2, single-arm study evaluating neoadjuvant and adjuvant toripalimab plus cetuximab in local…
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CLINICAL_TRIALS research · 2025-07-31Clinical Trial Update: Sacituzumab Tirumotecan and Toripalimab in the First-line Treatment of HNSCC [Phase 2]
Phase 2 trial examining the combination of sacituzumab tirumotecan and toripalimab as first-line therapy for recurrent or metastatic head an…
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CLINICAL_TRIALS research · 2025-07-31Clinical Trial Update: Low-Dose Weekly vs High-Dose Cisplatin [NA]
A clinical trial comparing low-dose weekly versus high-dose cisplatin in locally advanced head and neck squamous cell carcinoma is currently…
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CLINICAL_TRIALS research · 2025-07-31Clinical Trial Update: Iparomlimab and Tuvonralimab in HNSCC [Phase 2]
Phase 2 trial investigating iparomlimab and tuvonralimab for recurrent/metastatic head and neck squamous cell carcinoma is currently recruit…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: PD-1 Inhibitor Therapy Versus Radiotherapy in MPR Patients With Locally Advanced HNSCC After Neoadjuvant Immunochemotherapy (HNC-SYSU-006) [Phase 2]
This phase 2 clinical trial compares PD-1 inhibitor therapy to radiotherapy in locally advanced head and neck squamous cell carcinoma patien…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: Identification of the Pathogenetic Mechanisms Underlying Squamous Cell Carcinomas
A clinical trial focused on identifying the pathogenetic mechanisms underlying squamous cell carcinomas of the head and neck and anus; curre…
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CLINICAL_TRIALS research · 2025-07-25Clinical Trial Update: Thermoradiotherapy for Locally Advanced Head and Neck Cancer Patients [Phase 1]
Phase 1 clinical trial evaluating thermoradiotherapy for locally advanced head and neck cancers; recruitment is ongoing.
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CLINICAL_TRIALS research · 2025-07-24Clinical Trial Update: Testing the Safety of Giving a Standard Dose of Radiation Over a Shorter Period of Time for Patients Who Had Surgery for Intermediate-Risk Head and Neck Cancer [Phase 1]
Phase 1 clinical trial assessing the safety of delivering a standard dose of radiation over a shorter period after surgery for intermediate-…
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: VX15/2503 in Combination With Ipilimumab or Nivolumab in Patients With Head and Neck Cancer [Phase 1]
Phase 1 trial evaluating VX15/2503 in combination with ipilimumab or nivolumab for head and neck squamous cell carcinoma; currently recruiti…
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: A Trial of SHR-A2102 With Adebrelimab With or Without Other Anti-tumor Therapies in Recurrent/MetastaticHead and Neck Squamous Cell Carcinoma Cancer [Phase 1, Phase 2]
Clinical trial update describes a Phase 1/2 study of SHR-A2102 combined with Adebrelimab, with or without other anti-tumor therapies, in rec…
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CLINICAL_TRIALS research · 2025-07-20Clinical Trial Update: d-Limonene +Radiation +PlatinumBasedChemo for Xerostomia Prevention in LocallyAdvanced HNSCC [Phase 1]
A Phase 1 clinical trial is evaluating the addition of d-Limonene to radiation and platinum-based chemotherapy to prevent xerostomia in pati…
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CLINICAL_TRIALS research · 2025-07-18Clinical Trial Update: Dalpicilib Plus Cetuximab Compared With Cetuximab Alone in HPV-negative, Anti-PD-1-resistant R/M HNSCC [Phase 2]
This is a Phase 2 trial comparing dalpicilib plus cetuximab versus cetuximab alone in HPV-negative, anti-PD-1-resistant recurrent/metastatic…
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CLINICAL_TRIALS research · 2025-07-16Clinical Trial Update: 89Zr-Panitumumab for Assessment of Suspected Metastatic Lesions on 18F-FDG-PET/CT in HNSCC [Phase 2]
Phase 2 trial evaluating 89Zr-Panitumumab as an imaging agent to detect suspected metastatic lesions on 18F-FDG PET/CT in head and neck squa…
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CLINICAL_TRIALS research · 2025-07-15Clinical Trial Update: A Long-Term Follow-Up Study of Participants Treated With A2 Biotherapeutics (A2 Bio) Gene Therapy (GT) Products
This clinical trial update reports long-term follow-up of participants treated with A2 Biotherapeutics' gene therapy products in solid tumor…
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CLINICAL_TRIALS research · 2025-07-10Clinical Trial Update: Study of MEDI0562 Prior to Surgical Resection in Head and Neck Squamous Cell Carcinoma (HNSCC) or Melanoma [Phase 1]
This is a Phase 1 clinical trial evaluating MEDI0562 before surgical resection in head and neck squamous cell carcinoma or melanoma; the stu…