Graves Ophthalmopathy
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CLINICAL_TRIALS trial_result · 2022-09-22Clinical Trial Update: ASCEND GO-2: Study of RVT-1401 for the Treatment of Participants With Active, Moderate to Severe Graves' Ophthalmopathy ( GO ) [Phase 2]
Phase 2 study of RVT-1401 for Graves' Ophthalmopathy was terminated; results posted in 2022.
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CLINICAL_TRIALS trial_result · 2022-08-04Clinical Trial Update: Tocilizumab in Active Moderate-severe Graves' Orbitopathy [Phase 2]
Phase 2 clinical trial update evaluating tocilizumab for active moderate-to-severe Graves' ophthalmopathy.
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CLINICAL_TRIALS trial_result · 2022-01-24Clinical Trial Update: Study of RVT-1401 for the Treatment of Patients With Moderate to Severe Active Graves' Ophthalmopathy (GO) [Phase 2]
Phase 2 trial of RVT-1401 for Graves' Ophthalmopathy completed; results posted in 2022.
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CLINICAL_TRIALS trial_result · 2021-11-17Clinical Trial Update: Doxycycline Treatment in Mild Thyroid-Associated Ophthalmopathy [Phase 2]
Phase 2 clinical trial update evaluating doxycycline for mild thyroid-associated ophthalmopathy (Graves-related eye disease).
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FDA approval · 2021-10-26FDA Approved: TEPEZZA — Supplemental Application (Horizon Therapeutics USA, Inc.)
FDA approved a supplemental application for TEPEZZA (teprotumumab) by Horizon Therapeutics USA, Inc.
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FDA approval · 2020-01-21FDA Approved: TEPEZZA — Original Application (Horizon Therapeutics USA, Inc.)
The FDA approved TEPEZZA (teprotumumab) from Horizon Therapeutics USA, Inc. under an original biologics license application. This marks the …
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CLINICAL_TRIALS research · 2019-01-30Clinical Trial Update: The Effects of Metformin in Patients With Mild Graves' Ophthalmopathy [NA]
A clinical trial update reports on the effects of metformin in patients with mild Graves' ophthalmopathy, but the trial status is unknown.
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CLINICAL_TRIALS trial_result · 2018-09-13Clinical Trial Update: Liver Function After Intravenous Methylprednisolone Administration [Phase 4]
A Phase 4 clinical trial update evaluating liver function following intravenous methylprednisolone administration in Graves disease and Grav…
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CLINICAL_TRIALS trial_result · 2018-07-30Clinical Trial Update: Anti-insulin-like Growth Factor-1 Receptor (IGF-1R) Antibodies in Graves' Disease and Graves' Orbitopathy
Clinical trial update on anti-IGF-1R antibodies for Graves' disease and Graves' ophthalmopathy; the study status is completed.
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CLINICAL_TRIALS trial_result · 2018-07-18Clinical Trial Update: Impact of Intravenous Methylprednisolone Treatment on Blood Pressure
The clinical trial evaluating intravenous methylprednisolone's impact on blood pressure in Graves disease and Graves ophthalmopathy has comp…
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CLINICAL_TRIALS trial_result · 2018-05-24Clinical Trial Update: Coagulation After Intravenous Methylprednisolone Administration
The document summarizes the completed clinical trial evaluating coagulation effects after intravenous methylprednisolone administration in p…
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CLINICAL_TRIALS trial_result · 2018-02-19Clinical Trial Update: Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues [Phase 3]
Phase 3 trial assessing prostaglandin analogue drops for treating soft tissue expansion in inactive thyroid eye disease (thyroid-associated …
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CLINICAL_TRIALS research · 2017-11-28Clinical Trial Update: Retinal Oxygen Saturation in Patients With Graves' Ophthalmopathy and in Normal People
A clinical trial update examining retinal oxygen saturation in patients with Graves' ophthalmopathy and in healthy controls.
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CLINICAL_TRIALS research · 2017-10-31Clinical Trial Update: Observing the Relationship of Fibroblast Growth Factor and Fibroblast in Thyroid Eye Disease
A clinical trial update from National Taiwan University Hospital investigates the relationship between fibroblast growth factor and fibrobla…
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CLINICAL_TRIALS trial_result · 2017-08-30Clinical Trial Update: Teprotumumab (RV 001) Treatment in Patients With Active Thyroid Eye Disease [Phase 2]
Phase 2 trial of teprotumumab in active thyroid eye disease completed; results were posted in 2017.
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CLINICAL_TRIALS trial_result · 2017-08-03Clinical Trial Update: A Safety and Tolerability Study of Otelixizumab in Thyroid Eye Disease [Phase 2]
Phase 2 safety and tolerability study of Otelixizumab in Graves Ophthalmopathy was terminated; results posted in 2017.
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CLINICAL_TRIALS trial_result · 2017-05-30Clinical Trial Update: Randomized Study of Sequential Orbital Radiotherapy for Graves' Ophthalmopathy [NA]
The randomized study evaluating sequential orbital radiotherapy for Graves' ophthalmopathy has completed.
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CLINICAL_TRIALS withdrawal · 2017-04-27Clinical Trial Update: Use of Azithromycin as Immunomodulatory Therapy in Grave&Apos;s Orbitopathy [Phase 1, Phase 2]
A Phase 1 and Phase 2 trial investigating azithromycin as an immunomodulatory therapy for Graves' ophthalmopathy has been withdrawn.
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CLINICAL_TRIALS trial_result · 2017-04-06Clinical Trial Update: Disappearance of Graves' Orbitopathy
A completed clinical trial by the University of Pisa in Thyroid Eye Disease reports disappearance of Graves' ophthalmopathy.
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CLINICAL_TRIALS trial_result · 2017-02-28Clinical Trial Update: Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy [Phase 3]
Phase 3 clinical trial update comparing total thyroidectomy to thionamide therapy in patients with moderate-to-severe Graves' ophthalmopathy…
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CLINICAL_TRIALS trial_result · 2016-05-10Clinical Trial Update: Optic Disc, Macula, and Retinal Nerve Fiber Layer Measurements Obtained by OCT in Thyroid Associated Ophthalmopathy [NA]
A completed clinical trial evaluated optic disc, macula, and retinal nerve fiber layer measurements using OCT in Graves' ophthalmopathy.
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CLINICAL_TRIALS trial_result · 2016-05-06Clinical Trial Update: Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) [Phase 4]
Phase 4 clinical trial evaluating Prostaglandin F2-alpha Eye Drops for Graves' Ophthalmopathy has completed (Bima Study).
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CLINICAL_TRIALS trial_result · 2016-02-24Clinical Trial Update: Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) [Phase 4]
This document reports the completion of a Phase 4 clinical trial evaluating adjuvant NSAID therapy for Graves' ophthalmopathy in Graves' dis…
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CLINICAL_TRIALS trial_result · 2016-01-20Clinical Trial Update: Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease) [Phase 3]
Phase 3 trial assessing tocilizumab for Graves' ophthalmopathy (thyroid eye disease) has completed.
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CLINICAL_TRIALS withdrawal · 2015-06-03Clinical Trial Update: Use of Botox in the Management of Thyroid Related Upper Eyelid Retraction [Phase 4]
Phase 4 clinical trial evaluating Botox for thyroid-related upper eyelid retraction in Graves' ophthalmopathy has been withdrawn.