Glioblastoma

• CLINICAL_TRIALS trial_result · 2025-05-21
  Clinical Trial Update: Study to Evaluate Ibudilast and TMZ Combo Treatment in Newly Diagnosed and Recurrent Glioblastoma [Phase 1, Phase 2]

  A Phase 1/Phase 2 clinical trial evaluating the combination of ibudilast and temozolomide in newly diagnosed and recurrent glioblastoma has …

• CLINICAL_TRIALS research · 2025-05-21
  Clinical Trial Update: Conventional Versus Hypofractionated Radiotherapy With Temozolomide in Elderly Glioblastoma [Phase 3]

  A Phase 3 trial comparing conventional versus hypofractionated radiotherapy with temozolomide in elderly glioblastoma patients is currently …

• CLINICAL_TRIALS withdrawal · 2025-05-21
  Clinical Trial Update: Genetic Testing of Cerebrospinal Fluid to Diagnose and Monitor Glioblastoma [NA]

  This clinical trial investigating cerebrospinal fluid genetic testing to diagnose and monitor glioblastoma has been withdrawn.

• CLINICAL_TRIALS research · 2025-05-20
  Clinical Trial Update: Phase I/II Study of Pazopanib+ Temozolomide in Patients With Newly Diagnosed Glioblastoma Multiforme [Phase 1, Phase 2]

  Phase I/II trial updating the combination of pazopanib and temozolomide for newly diagnosed glioblastoma multiforme, currently recruiting.

• CLINICAL_TRIALS research · 2025-05-16
  Clinical Trial Update: Personalized Cancer Stem Cell High-Throughput Drug Screening for Glioblastoma [EARLY_Phase 1]

  An early-phase 1 clinical trial at Swedish Medical Center is exploring personalized cancer stem cell high-throughput drug screening for newl…

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• CLINICAL_TRIALS research · 2025-05-16
  Clinical Trial Update: Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) in Glioma (WHO G3-G4) Progression [NA]

  This entry notes that recruitment is ongoing for a local alpha-emitter therapy, [225Ac]Ac-DOTA-SP (TAT), being studied for glioblastoma and …

• CLINICAL_TRIALS research · 2025-05-15
  Clinical Trial Update: Temozolomide, Radiation Therapy, and Tumor Treating Fields Therapy in Treating Participants With Glioblastoma [EARLY_Phase 1]

  An early-phase 1 clinical trial evaluating Temozolomide in combination with radiation therapy and Tumor Treating Fields Therapy for glioblas…

• CLINICAL_TRIALS trial_result · 2025-05-15
  Clinical Trial Update: UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-3 (UNITED-3) [NA]

  UNITED-3 is evaluating unity-based MR-Linac guided adaptive radiotherapy for high-grade glioma (glioblastoma) in adults. The study is curren…

• CLINICAL_TRIALS other · 2025-05-14
  Clinical Trial Update: PD L 506 for Stereotactic Interstitial Photodynamic Therapy of Newly Diagnosed Supratentorial IDH Wild-type Glioblastoma [Phase 2]

  Clinical trial update for PD L 506 in stereotactic interstitial photodynamic therapy for newly diagnosed IDH wild-type glioblastoma. The Pha…

• CLINICAL_TRIALS trial_result · 2025-05-13
  Clinical Trial Update: Pembrolizumab in Association With the IMA950/Poly-ICLC for Relapsing Glioblastoma [Phase 1, Phase 2]

  A phase 1/2 clinical trial evaluating pembrolizumab in combination with the IMA950 multipeptide vaccine and Poly-ICLC adjuvant for relapsing…

• CLINICAL_TRIALS research · 2025-05-07
  Clinical Trial Update: A Study of BL-B01D1 in Patients With Recurrent Glioblastoma [Phase 2]

  Phase 2 clinical trial update for BL-B01D1 in recurrent glioblastoma; the study is currently recruiting.

• CLINICAL_TRIALS research · 2025-05-04
  Clinical Trial Update: Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults [Phase 1]

  Phase 1 clinical trial evaluating immunotherapy before and after surgery for recurrent or progressive high-grade glioma in children and youn…

• CLINICAL_TRIALS research · 2025-05-01
  Clinical Trial Update: A Phase 1b / 2 Drug Resistant Immunotherapy With Activated, Gene Modified Allogeneic or Autologous γδ T Cells (DeltEx) in Combination With Maintenance Temozolomide in Subjects With Recurrent or Newly Diagnosed Glioblastoma [Phase 1, Phase 2]

  This clinical trial update covers a Phase 1b/2 study evaluating DeltEx, an activated, gene-modified γδ T cell therapy, in combination with m…

• CLINICAL_TRIALS research · 2025-04-25
  Clinical Trial Update: 5G-EMERALD: Amivantamab in Malignant Brain Tumours [Phase 1]

  A Phase 1 clinical trial of amivantamab for malignant brain tumors, including glioblastoma and related gliomas, is currently recruiting in t…

• CLINICAL_TRIALS trial_result · 2025-04-25
  Clinical Trial Update: Pilot Trial for Treatment of Recurrent Glioblastoma [EARLY_Phase 1]

  A pilot early-phase 1 trial evaluating a treatment for recurrent glioblastoma is currently recruiting, sponsored by AHS Cancer Control Alber…

• CLINICAL_TRIALS research · 2025-04-20
  Clinical Trial Update: Enhanced Adjuvant Therapy for Newly Diagnosed GBM With Partial Surgical Resection or Short-term Progression [Phase 2]

  A Phase 2 clinical trial update on enhanced adjuvant therapy for newly diagnosed glioblastoma with partial surgical resection or short-term …

• CLINICAL_TRIALS trial_result · 2025-04-18
  Clinical Trial Update: Study of Ad-RTS-hIL-12 + Veledimex in Combination With Cemiplimab in Subjects With Recurrent or Progressive Glioblastoma [Phase 2]

  Phase 2 trial evaluating Ad-RTS-hIL-12 plus Veledimex in combination with cemiplimab for recurrent or progressive glioblastoma was terminate…

• CLINICAL_TRIALS trial_result · 2025-04-18
  Clinical Trial Update: Radiation/Temozolomide and Immunotherapy With Daratumumab to Improve Antitumor Efficacy in Glioblastoma [Phase 1, Phase 2]

  A phase 1/2 study evaluating radiation/temozolomide with daratumumab immunotherapy for glioblastoma; the trial is currently active but not r…

• CLINICAL_TRIALS trial_result · 2025-04-16
  Clinical Trial Update: A Study of Ad-RTS-hIL-12 With Veledimex in Subjects With Glioblastoma or Malignant Glioma [Phase 1]

  Phase 1 study evaluating Ad-RTS-hIL-12 in combination with Veledimex for glioblastoma and malignant glioma has completed enrollment, with re…

• CLINICAL_TRIALS research · 2025-04-16
  Clinical Trial Update: Research on the Safety and Efficacy of Intraoperative Radiation Therapy in Malignant Cerebral Tumor [NA]

  This entry describes a clinical trial evaluating intraoperative radiation therapy for malignant brain tumors, including glioblastoma, which …

• CLINICAL_TRIALS research · 2025-04-15
  Clinical Trial Update: DC Migration Study to Evaluate TReg Depletion In GBM Patients With and Without Varlilumab [Phase 2]

  A Phase 2 clinical trial update describes a study evaluating dendritic cell migration and regulatory T cell depletion in glioblastoma patien…

• CLINICAL_TRIALS research · 2025-04-11
  Clinical Trial Update: A Study of Chlorophyllin for the Management of Brain Radio-necrosis in Patients With Diffuse Glioma [Phase 2]

  Phase 2 clinical trial evaluating chlorophyllin for the management of brain radionecrosis in patients with diffuse glioma is currently recru…

• CLINICAL_TRIALS research · 2025-04-11
  Clinical Trial Update: TTFields General Routine Clinical Care in ndGBM Patients: a French Prospective Non-Interventional Study (TIGER France)

  A French prospective non-interventional study (TIGER France) is assessing general routine TTFields care in newly diagnosed glioblastoma pati…

• CLINICAL_TRIALS trial_result · 2025-04-10
  Clinical Trial Update: Disulfiram/Copper With Concurrent Radiation Therapy and Temozolomide in Patients With Newly Diagnosed Glioblastoma [Phase 1, Phase 2]

  A Phase 1/2 trial evaluated disulfiram with copper in combination with radiation therapy and temozolomide for newly diagnosed glioblastoma; …

• CLINICAL_TRIALS withdrawal · 2025-04-10
  Clinical Trial Update: Post-operative Adjuvant Therapy w/wo GammaTile + Systemic Therapy [Phase 4]

  A Phase 4 trial evaluating post-operative adjuvant therapy with or without GammaTile plus systemic therapy for glioblastoma has been withdra…