Glioblastoma
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CLINICAL_TRIALS research · 2025-12-24Clinical Trial Update: A Phase 2 Study of the Ketogenic Diet vs Standard Anti-cancer Diet Guidance for Patients With Glioblastoma in Combination With Standard-of-care Treatment [Phase 2]
A Phase 2 trial comparing ketogenic diet with standard anti-cancer diet guidance in patients with glioblastoma receiving standard-of-care tr…
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer [Phase 1]
A Phase 1 study is evaluating the safety and tolerability of AZD1390 in combination with radiation therapy for brain cancer, including prima…
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: Atezolizumab and Pre-Surgical Brain Radiation Therapy for Glioblastoma Multiforme [EARLY_Phase 1]
An early-phase trial is evaluating atezolizumab in combination with pre-surgical brain radiation therapy for glioblastoma and is currently r…
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: A Clinical Trial Evaluating the Efficacy of Valganciclovir in Glioblastoma Patients [Phase 2]
This is an update on a Phase 2 clinical trial evaluating valganciclovir in patients with glioblastoma; the study (NCT04116411) is currently …
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CLINICAL_TRIALS research · 2025-12-19Clinical Trial Update: Clinical Study of Oncolytic Virus in Glioblastoma [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating an oncolytic virus for glioblastoma is currently recruiting.
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CLINICAL_TRIALS research · 2025-12-19Clinical Trial Update: Triapine in Combination With Temozolomide for the Treatment of Patients With Recurrent Glioblastoma [Phase 1]
Phase 1 study of TRIAPINE in combination with temozolomide for recurrent glioblastoma and recurrent gliomas; currently listed as active but …
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CLINICAL_TRIALS research · 2025-12-19Clinical Trial Update: Atezolizumab and Cabozantinib for the Treatment of Recurrent Glioblastoma [Phase 1, Phase 2]
A phase 1/2 clinical trial is evaluating the combination of atezolizumab and cabozantinib for recurrent glioblastoma and recurrent gliosarco…
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CLINICAL_TRIALS research · 2025-12-19Clinical Trial Update: A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging [Phase 2]
Phase 2 pilot study assessing feasibility of combining a ketogenic diet with metformin for glioblastoma, with metabolic imaging endpoints; c…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Peds CHAMP1ON - Hematopoietic Stem Cell And Monoclonal Antibody PD-1 Blockade for RecurreNt Pediatric High-Grade Glioma [Phase 1]
A Phase 1 clinical trial in pediatric patients with recurrent high-grade glioma evaluating hematopoietic stem cell therapy in combination wi…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms [Phase 1]
Phase I trial update indicates ONC206 is being studied for recurrent and rare primary central nervous system neoplasms and the study is curr…
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma. [Phase 1]
Phase 1 trial update on an adenovirus-mediated suicide gene therapy combined with radiotherapy for progressive astrocytoma; the study is cur…
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Vortioxetine for Newly Diagnosed Glioblastoma [Phase 2]
A Phase 2 clinical trial update from the University of Zurich investigates vortioxetine for newly diagnosed glioblastoma and is not yet recr…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Tofacitinib in Recurrent GBM Patients [Phase 3]
Phase 3 clinical trial update for tofacitinib in recurrent glioblastoma; the study is active but not recruiting.
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Different Approaches for CART-EGFR-IL13Ra2 Dosing in Recurrent GBM [Phase 1]
Provides an update on dosing strategies being explored in a Phase 1 trial of CART-EGFR-IL13Ra2 for recurrent glioblastoma, which is currentl…
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: Assessment of Early Post-operative Nuclear Imaging in Neurosurgery: a Safety and Feasibility Study in Patients Operated for Glioblastoma [NA]
Clinical trial update describing a safety and feasibility study of early post-operative nuclear imaging in glioblastoma patients; recruitmen…
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CLINICAL_TRIALS research · 2025-12-09Clinical Trial Update: Phase 1/2 Study of Silevertinib (BDTX-1535) in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations [Phase 1, Phase 2]
Phase 1/2 study of Silevertinib (BDTX-1535) in glioblastoma and EGFR-mutant non-small cell lung cancer is currently active but not recruitin…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age [Phase 1, Phase 2]
A Phase 1/2 clinical trial update for relapsed/refractory intracranial glioma in patients under 22 years, currently recruiting.
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Phase I/IIa Study of Concomitant Radiotherapy With Olaparib and Temozolomide in Unresectable High Grade Gliomas Patients [Phase 1, Phase 2]
A Phase I/IIa clinical trial is evaluating the safety and feasibility of combining radiotherapy with olaparib and temozolomide in unresectab…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: A Safety Study of Pharmacologic Ascorbate and Ferumoxytol in Addition to Standard of Care Chemoradiation in Glioblastoma [Phase 1]
Phase 1 safety study evaluating pharmacologic ascorbate and ferumoxytol in addition to standard-of-care chemoradiation for glioblastoma.
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Silibinin in Association With Concomitant Chemoradiotherapy and Maintenance Temozolomide in STAT3 Positive IDH Wild-type, Newly Diagnosed Glioblastoma Patients [NA]
This clinical trial is evaluating silibinin in combination with concomitant chemoradiotherapy and maintenance temozolomide for newly diagnos…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma [EARLY_Phase 1]
Early-phase, multi-tracer PET imaging study combining [18F]Fluciclovine and 18F-FDG PET with advanced MRI for metabolic profiling in gliobla…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: A Phase I/II Clinical Trial on the Per-operative Intratumoral Administration of Myeloid Dendritic Cells Plus Ipilimumab and Nivolumab, Followed by Repeated Intracavitary Plus Intravenous Administration of Nivolumab in Patients With Recurrent Glioblastoma. [Phase 1, Phase 2]
Phase I/II trial evaluating per-operative intratumoral autologous myeloid dendritic cells with ipilimumab and nivolumab, followed by repeate…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM) [Phase 2]
A Phase 2 clinical trial evaluating hematopoietic stem cell rescue for glioblastoma (hSTAR GBM) is currently recruiting.
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: Oxidative Phosphorylation Targeting In Malignant Glioma Using Metformin Plus Radiotherapy Temozolomide [Phase 2]
Phase 2 clinical trial evaluating metformin plus radiotherapy and temozolomide to target oxidative phosphorylation in glioblastoma, IDH-wild…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions [EARLY_Phase 1]
A Phase 0/1 study of BDTX-1535 in patients with recurrent high-grade glioma and newly diagnosed glioblastoma with EGFR alterations or fusion…