Glioblastoma
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) In Newly Diagnosed Glioma (WHO G3-G4) [NA]
A clinical trial is evaluating local targeted alpha emitter therapy using 225Ac-DOTA-SP (TAT) for newly diagnosed glioma (WHO grade 3-4) and…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma [Phase 3]
A Phase 3 trial is evaluating adding lomustine to standard temozolomide and radiation therapy for newly diagnosed MGMT-methylated glioblasto…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma [NA]
This clinical trial update discusses the use of DSC-MRI derived rCBV to measure early response to bevacizumab in patients with recurrent gli…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Identifying Findings on Brain Scans That Could Help Make Better Predictions About Brain Cancer Progression, The GABLE Trial [Phase 2]
A Phase 2 clinical trial named GABLE is investigating imaging findings that could help predict progression in glioblastoma, IDH-wildtype, an…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: The Feasibility and Efficacy of Dose Timing (Morning vs Evening) of Temozolomide in the Treatment of Glioblastoma [NA]
This clinical trial will assess whether administering temozolomide in the morning versus the evening is feasible and potentially more effect…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma [Phase 3]
This entry describes an ongoing Phase 3 clinical trial comparing niraparib to temozolomide in adults with newly diagnosed MGMT unmethylated …
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Targeted Pediatric High-Grade Glioma Therapy
A pediatric clinical trial is currently recruiting to evaluate a targeted therapy for high-grade gliomas, including diffuse intrinsic pontin…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Azeliragon in MGMT Unmethylated Glioblastoma [Phase 2]
Phase 2 clinical trial update for Azeliragon in MGMT unmethylated glioblastoma. The study is currently listed as active but not recruiting.
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: A Phase Ib/II Clinical Trial to Evaluate the Safety and Efficacy of JL15003 Injection in Patients With Recurrent Glioblastoma (rGBM) [Phase 1, Phase 2]
This clinical trial update describes a Phase Ib/II study of JL15003 injection for recurrent glioblastoma and notes that the study is current…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: A Phase 1b/2a Study to Evaluate the Safety, Pharmacokinetics, and Objective Response of STAR-001 (LP-184) in Combination With Spironolactone in Supratentorial Glioblastoma at First Progression [Phase 1, Phase 2]
This clinical trial update describes a Phase 1b/2a study evaluating STAR-001 (LP-184) in combination with spironolactone for supratentorial …
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Sacituzumab Govitecan in Recurrent Glioblastoma [Phase 2]
A Phase 2 clinical trial evaluating sacituzumab govitecan for recurrent glioblastoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM [Phase 1, Phase 2]
A Phase 1/2 clinical trial update evaluating HSV-tk gene therapy with valacyclovir and SBRT plus chemotherapy for recurrent glioblastoma and…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating HSV-tk gene therapy in combination with radiotherapy and chemotherapy for newly diagnosed glioblastoma…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM [Phase 1]
A Phase 1 feasibility trial is evaluating the safety of the TheraSphere Glioblastoma Device in patients with recurrent glioblastoma; the stu…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Multiple Intracerebral Doses of Neural Stem Cell-Based Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas [Phase 1]
A Phase 1 study of multiple intracerebral doses of NSC-CRAd-S-pk7 for recurrent high-grade gliomas (glioblastoma) is currently suspended.
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Comparison of Skin Closure Techniques in Oncological Neurosurgical Procedures: Intradermal Running Suture Versus Transdermal Interrupted Sutures [NA]
This clinical trial compares intradermal running sutures with transdermal interrupted sutures for skin closure in oncologic neurosurgical pr…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Music Therapy in Newly Diagnosed Glioblastoma After Chemoradiation Therapy (MELODY-GBM) [NA]
A feasibility study (MELODY-GBM) evaluating music therapy for patients with newly diagnosed glioblastoma after chemoradiation is not yet rec…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Hypofractionated Radiotherapy Plus Temozolamide in Patients Younger Than 70 Years With Glioblastoma [NA]
A clinical trial is evaluating hypofractionated radiotherapy plus temozolomide in patients younger than 70 with glioblastoma. The study stat…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures [EARLY_Phase 1]
This document describes a NOT_YET_RECRUITING Phase 1 pilot study evaluating Panitumumab-IRDye800 as an optical imaging agent to detect intra…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Clinical Study of a Novel Oncolytic Virus Ad-TD-nsIL12 in the Treatment of Primary High-grade Glioma [Phase 1, Phase 2]
Clinical trial update for Ad-TD-nsIL12, an oncolytic virus, in primary high-grade glioma, currently in Phase 1/Phase 2 and enrolling by invi…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Safety and Efficacy of CTX-009 With or Without CTX-471 for Recurrent Glioblastoma [Phase 1, Phase 2]
A Phase 1/Phase 2 clinical trial is evaluating CTX-009 with or without CTX-471 for recurrent glioblastoma; recruitment has not yet begun.
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: A Study for Cerebral Open Flow Microperfusion [NA]
A Mayo Clinic study evaluating cerebral open flow microperfusion for glioma and glioblastoma is listed as not yet recruiting.
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors [Phase 1]
Phase 1 clinical trial update evaluating the safety and tolerability of the radiopharmaceutical 212Pb-DOTAM-GRPR1 in adults with recurrent o…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Phase 0/2 PD-Trigger Study of BGB-58067 in Newly Diagnosed Glioblastoma Patients With MTAP-Deleted Tumors [EARLY_Phase 1]
An early-phase Phase 0/2 trial evaluating BGB-58067 in newly diagnosed glioblastoma with MTAP deletion; the study is currently not yet recru…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma [Phase 1]
This is a Phase 1 safety and dose-finding trial of GLIX1 in adults with recurrent or progressive high-grade glioma, currently not yet recrui…