Glioblastoma
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CLINICAL_TRIALS research · 2025-09-18Clinical Trial Update: DLL3 CAR-T Therapy Targeting Brain Tumors [Phase 1, Phase 2]
This document reports an ongoing phase 1/2 clinical trial of a DLL3-targeted CAR-T therapy for glioblastoma that is currently recruiting.
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CLINICAL_TRIALS research · 2025-09-18Clinical Trial Update: Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: A Phase 2 Hybrid Randomized Trial [Phase 2]
A Phase 2 hybrid randomized trial is evaluating enhanced local intensified radiation therapy for elderly patients with glioblastoma and is c…
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CLINICAL_TRIALS research · 2025-09-17Clinical Trial Update: Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy [Phase 1]
A Phase 1 clinical trial is evaluating focused ultrasound to disrupt the blood-brain barrier in high-grade glioma patients undergoing standa…
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Study of DSP-0390 in Patients With Recurrent High-Grade Glioma [EARLY_Phase 1]
DSP-0390 is being studied in an early-phase Phase 1 trial for recurrent high-grade glioma, including glioblastoma, and the study is currentl…
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Combined Treatment of Patients With Newly Diagnosed Glioblastoma Using the Xoft® Axxent® Electronic Brachytherapy (eBx®) System for Intraoperative Balloon Electronic Brachytherapy [Phase 1]
An early-phase Phase 1 study evaluating the use of the Xoft Axxent electronic brachytherapy system for intraoperative balloon brachytherapy …
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: A Study to Better Understand the Biological and Molecular Mechanisms Involved in Glioblastoma Recurrence and Progression
This clinical trial aims to investigate the biological and molecular mechanisms underlying glioblastoma recurrence and progression.
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: A Dose-escalation Clinical Study of Intraoperative Photodynamic Therapy of Glioblastoma [Phase 1, Phase 2]
Dose-escalation Phase 1/2 clinical trial evaluating intraoperative photodynamic therapy for glioblastoma is currently recruiting.
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma [EARLY_Phase 1]
This update describes an early-phase window-of-opportunity trial of Troriluzole for recurrent IDH-wild-type glioblastoma, currently recruiti…
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CLINICAL_TRIALS research · 2025-09-09Clinical Trial Update: FearLess in NeuroOncology [NA]
Clinical trial update for FearLess in NeuroOncology indicates the study is currently recruiting for patients with glioblastoma and other pri…
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CLINICAL_TRIALS research · 2025-09-09Clinical Trial Update: A Multicenter, Prospective Study for Glioblastoma Patients
This document provides an update on a multicenter, prospective trial for patients with glioblastoma. The study is currently not recruiting.
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CLINICAL_TRIALS research · 2025-09-05Clinical Trial Update: A Study to Evaluate the Safety, Tolerability and Efficacy of RZ-001 With Valganciclovir (VGCV) in Subjects With Glioblastoma [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating the safety, tolerability and efficacy of RZ-001 in combination with valganciclovir for glioblastoma…
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CLINICAL_TRIALS research · 2025-09-05Clinical Trial Update: GammaTile and Stupp in Newly Diagnosed GBM [Phase 4]
Phase 4 clinical trial update on the use of GammaTile in combination with the Stupp regimen for newly diagnosed glioblastoma, with the trial…
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CLINICAL_TRIALS research · 2025-08-27Clinical Trial Update: Investigator-Initiated Study of Imipramine Hydrochloride and Lomustine in Recurrent Glioblastoma [Phase 2]
Clinical trial update describing a Phase 2 investigator-initiated study evaluating imipramine hydrochloride in combination with lomustine fo…
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CLINICAL_TRIALS research · 2025-08-27Clinical Trial Update: Allogeneic γδT Cells in Glioblastoma [NA]
A clinical trial evaluating allogeneic γδT cells in glioblastoma is currently recruiting, sponsored by Peking University Third Hospital.
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CLINICAL_TRIALS research · 2025-08-26Clinical Trial Update: Improving Understanding of Brain Tumors Through Preservation of Biologically Active Brain Tissue [NA]
This clinical trial update describes a study aimed at improving understanding of brain tumors by preserving biologically active brain tissue…
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CLINICAL_TRIALS research · 2025-08-26Clinical Trial Update: ADI-PEG 20 Plus Radiotherapy and Temozolomide in Subjects With Glioblastoma Multiforme [Phase 2]
A Phase 2 clinical trial update on ADI-PEG 20 with radiotherapy and temozolomide for glioblastoma, with the study currently active but not r…
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CLINICAL_TRIALS research · 2025-08-26Clinical Trial Update: Serial MRI Scans During Radiation Therapy [NA]
ClinicalTrials.gov entry for a Dana-Farber Cancer Institute study evaluating serial MRI scans during radiation therapy for glioblastoma and …
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CLINICAL_TRIALS research · 2025-08-22Clinical Trial Update: Phase 2 Clinical Trial of KH617 [Phase 2]
A Phase 2 clinical trial of KH617 for recurrent glioblastoma is listed as not yet recruiting.
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: Sonodynamic-Chemoradiotherapy Integration in Glioblastoma [Phase 2]
Phase 2 clinical trial update evaluating sonodynamic-chemoradiotherapy integration for glioblastoma; enrollment is ongoing by invitation.
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma [Phase 1, Phase 2]
This update describes a Phase 1/2 trial evaluating the combination of NMS-03305293 and temozolomide in adults with recurrent glioblastoma; t…
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CLINICAL_TRIALS research · 2025-08-17Clinical Trial Update: A Study to Evaluate ERAS-801 in Patients With Recurrent Glioblastoma (THUNDERBBOLT-1) [Phase 1]
A Phase 1 study (THUNDERBBOLT-1) evaluating ERAS-801 in recurrent glioblastoma is active but not recruiting.
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CLINICAL_TRIALS research · 2025-08-17Clinical Trial Update: Lerapolturev (PVSRIPO) in GBM [Phase 2]
Lerapolturev (PVSRIPO) is being studied in a Phase 2 trial for recurrent supratentorial glioblastoma and is currently recruiting.
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CLINICAL_TRIALS research · 2025-08-15Clinical Trial Update: Psychological and Psychiatric prOfile in Glioblastoma and Head and Neck Cancer
This clinical trial study assesses the psychological and psychiatric profiles of patients with glioblastoma and head and neck cancer and is …
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: Glioblastoma Imaging for the Detection of Tumor Progression Using APTw-CEST MRI [NA]
This clinical trial is investigating the use of APTw-CEST MRI imaging to detect tumor progression in glioblastoma.
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CLINICAL_TRIALS research · 2025-08-13Clinical Trial Update: Molecular Imaging of Cancer-associated Fibroblasts in Glioblastoma: a FAPI PET/MR Study. [NA]
An ongoing clinical trial in glioblastoma is evaluating molecular imaging of cancer-associated fibroblasts using FAPI PET/MR.