Gastrointestinal Stromal Tumors
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CLINICAL_TRIALS trial_result · 2026-07-28Clinical Trial Results: Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST) [Phase 2]
Phase 2 clinical trial results for temozolomide in advanced SDH-mutant/deficient gastrointestinal stromal tumors have been completed and res…
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: Development of a Multimodal AI System for GIST Management
Completed clinical trial evaluating a multimodal AI system for managing gastrointestinal stromal tumors (GIST) and related gastric condition…
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: Expanded Access to Bezuclastinib to be Coadministered With Sunitinib for Patients With Gastrointestinal Stromal Tumors
Expanded access for bezuclastinib to be coadministered with sunitinib for patients with Gastrointestinal Stromal Tumors has been announced b…
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CLINICAL_TRIALS trial_result · 2026-01-20Clinical Trial Update: A Study of Pimitespib in Combination With Imatinib in Patients With GIST (CHAPTER-GIST-101) [Phase 1]
Phase 1 study CHAPTER-GIST-101 is evaluating pimitespib in combination with imatinib for gastrointestinal stromal tumors; the trial is curre…
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CLINICAL_TRIALS trial_result · 2025-09-11Clinical Trial Update: A Study of Avelumab In Combination With Axitinib in Patients With Unresectable/Metastatic Gastrointestinal Stromal Tumor After Failure of Standard Therapy [Phase 2]
Phase 2 study evaluating the combination of avelumab and axitinib in unresectable or metastatic gastrointestinal stromal tumors after failur…
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CLINICAL_TRIALS trial_result · 2025-03-03Clinical Trial Update: A Study of DCC-2618 (Ripretinib) In Patients With With Advanced Gastrointestinal Stromal Tumors (GIST) [Phase 2]
Phase 2 study of ripretinib (DCC-2618) in patients with advanced gastrointestinal stromal tumors has completed. Results have been posted.
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CLINICAL_TRIALS trial_result · 2025-02-14Clinical Trial Update: CGT9486 (Formerly Known as PLX9486) as a Single Agent and in Combination With PLX3397 (Pexidartinib) or Sunitinib in Participants With Advanced Solid Tumors [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating CGT9486 (PLX9486) as a single agent and in combination with PLX3397 (pexidartinib) or sunitinib in parti…
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CLINICAL_TRIALS trial_result · 2024-08-19Clinical Trial Update: Nilotinib Roll-over Protocol for Patients in Novartis-sponsored Nilotinib Study and Benefiting From Nilotinib Treatment [Phase 2]
A Phase 2 rollover protocol study of nilotinib for patients with Gastrointestinal Stromal Tumors has completed, and the trial results have b…
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CLINICAL_TRIALS trial_result · 2024-06-05Clinical Trial Update: A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST) [Phase 1, Phase 2]
The Phase 1/2 study of the investigational drug THE-630 in advanced Gastrointestinal Stromal Tumors was terminated, with results posted on 2…
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CLINICAL_TRIALS trial_result · 2024-02-15Clinical Trial Update: DS-6157a in Participants With Advanced Gastrointestinal Stromal Tumor (GIST) [Phase 1]
A Phase 1 clinical trial update for DS-6157a in advanced gastrointestinal stromal tumors has been terminated with results posted.
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CLINICAL_TRIALS trial_result · 2024-02-09Clinical Trial Update: Efficacy and Safety of Famitinib Versus Sunitinib in the Treatment of Advanced Gastrointestinal Stromal Tumour Patients After Failure of Imatinib [Phase 3]
Phase 3 trial comparing famitinib to sunitinib in advanced GIST after imatinib failure; study terminated.
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CLINICAL_TRIALS trial_result · 2024-02-08Clinical Trial Update: Study to Allow Access to Nilotinib for Patients Who Are on Nilotinib Treatment in a Novartis-sponsored Study [Phase 4]
Phase 4 trial update on allowing access to nilotinib for patients already receiving nilotinib in a Novartis-sponsored study; study status co…
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CLINICAL_TRIALS trial_result · 2024-01-05Clinical Trial Update: Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) [Phase 3]
Phase 3 trial evaluating whether continuing versus interrupting imatinib after 3 years of adjuvant therapy improves outcomes in patients wit…
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CLINICAL_TRIALS trial_result · 2023-04-27Clinical Trial Update: A Study of CS3007 in Subjects With Gastrointestinal Stromal Tumor [Phase 1, Phase 2]
Phase 1/2 clinical trial updating the study of CS3007 in patients with gastrointestinal stromal tumors has completed.
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CLINICAL_TRIALS trial_result · 2023-03-27Clinical Trial Update: Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST [Phase 2]
A Phase 2 study assessing regorafenib as a single agent in first-line treatment of metastatic/unresectable KIT/PDGFR wild-type gastrointesti…
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CLINICAL_TRIALS trial_result · 2023-03-27Clinical Trial Update: Selinexor as Single Agent and With Imatinib in Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (SeliGIST) [Phase 1, Phase 2]
An update on a phase 1/2 trial evaluating selinexor as a single agent and in combination with imatinib for metastatic and/or unresectable ga…
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CLINICAL_TRIALS trial_result · 2023-02-01Clinical Trial Update: Masitinib in First Line Treatment of Gastro-Intestinal Stromal Tumor (GIST) [Phase 3]
Phase 3 trial of masitinib in first-line treatment for gastrointestinal stromal tumors was terminated.
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CLINICAL_TRIALS trial_result · 2023-01-04Clinical Trial Update: A Study of Intermittent Dosing Schedule of Imatinib in Patients With Tyrosine Kinase Inhibitor Refractory GISTs [Phase 2]
Phase 2 trial assessing intermittent dosing of imatinib in patients with tyrosine kinase inhibitor-refractory gastrointestinal stromal tumor…
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CLINICAL_TRIALS trial_result · 2023-01-03Clinical Trial Update: PDR001 Plus Imatinib for Metastatic or Unresectable GIST [Phase 1, Phase 2]
Phase 1/2 trial of PDR001 plus imatinib in metastatic or unresectable gastrointestinal stromal tumors completed.
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CLINICAL_TRIALS trial_result · 2021-06-25Clinical Trial Update: Everolimus in Combination With Imatinib in Patients With Glivec Refractory/Resistant Gastrointestinal Stromal Tumors [Phase 1, Phase 2]
Phase 1/2 trial evaluating everolimus in combination with imatinib in gastrointestinal stromal tumors refractory or resistant to imatinib ha…
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CLINICAL_TRIALS trial_result · 2021-06-22Clinical Trial Update: (NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors [Phase 1]
Phase 1 trial update for BLU-285 in gastrointestinal stromal tumors and other relapsed/refractory solid tumors; results posted after complet…
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CLINICAL_TRIALS trial_result · 2021-04-23Clinical Trial Update: Phase 3 Study of DCC-2618 vs Placebo in Advanced GIST Patients Who Have Been Treated With Prior Anticancer Therapies [Phase 3]
Phase 3 study evaluating DCC-2618 (ripretinib) vs placebo in advanced gastrointestinal stromal tumor patients previously treated with antica…
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CLINICAL_TRIALS trial_result · 2020-12-08Clinical Trial Update: Masitinib in Patients With Gastrointestinal Stromal Tumour After Progression With Imatinib [Phase 3]
Phase 3 trial assessing masitinib in gastrointestinal stromal tumors after progression on imatinib has completed.
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CLINICAL_TRIALS trial_result · 2020-01-09Clinical Trial Update: Phase II Study of Regorafenib Continuous Dosing of Regorafenib in Patients With GISTs [Phase 2]
Phase II study results update for continuous dosing of regorafenib in patients with gastrointestinal stromal tumors (GISTs).
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CLINICAL_TRIALS trial_result · 2020-01-07Clinical Trial Update: Paclitaxel in Patients With Metastatic or Advanced Gastrointestinal Stromal Tumors (GIST) After Failure to Imatinib and Sunitinib [Phase 2]
Phase 2 clinical trial evaluating paclitaxel in patients with metastatic or advanced gastrointestinal stromal tumors after failure of imatin…