Gastroesophageal Junction Adenocarcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-08-03Clinical Trial Results: A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer) [Phase 1, Phase 2]
Phase 1/2 study evaluating multiple immunotherapy-based combinations in locally advanced unresectable or metastatic gastric/GEJ cancer and e…
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CLINICAL_TRIALS trial_result · 2026-07-07Clinical Trial Update: Neoadjuvant RCT Versus CT for Patients With Locally Advanced, Potentially Resectable Adenocarcinoma of the GEJ [Phase 3]
Phase 3 neoadjuvant trial comparing neoadjuvant therapy to chemotherapy for locally advanced, potentially resectable gastroesophageal juncti…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Dual-target CLDN18.2/HER2 CAR-NK Cells for Advanced Gastric/GEJ Cancer [Phase 1, Phase 2]
A Phase 1/2 clinical trial is recruiting to evaluate CLDN18.2/HER2-targeted CAR-NK cells for advanced gastric cancer and advanced gastroesop…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Adebrelimab Combined With Nab-paclitaxel, Oxaliplatin and Tegafur (AOS) for Perioperative Treatment of Locally Advanced Resectable GC/GEJ [Phase 2]
This Phase 2 trial investigates adebrelimab with nab-paclitaxel, oxaliplatin and tegafur (AOS) as perioperative therapy for locally advanced…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Study of ASP2138 Given by Itself or Given With Other Cancer Treatments in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, or Pancreatic Cancer [Phase 1]
A Phase 1 clinical trial evaluating ASP2138 given alone or with other cancer therapies in adults with gastric adenocarcinoma, gastroesophage…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma [Phase 3]
Phase 3 trial updating the design of a study comparing subcutaneous tislelizumab versus intravenous tislelizumab plus chemotherapy in unrese…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Testing Immunotherapy (Atezolizumab) With or Without Chemotherapy in Locoregional MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer [Phase 2]
Phase 2 trial evaluating atezolizumab with or without chemotherapy for locoregional MSI-H/dMMR gastric and gastroesophageal junction cancers…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Fruquintinib and Albumin-paclitaxel Combined With or Without PD-1 Antibody in 2nd-line Treatment of G/GEJ Adenocarcinoma
This clinical trial update describes a study evaluating fruquintinib plus albumin-bound paclitaxel with or without a PD-1 antibody as second…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial [Phase 2, Phase 3]
A Phase 2/Phase 3 clinical trial is evaluating nivolumab added to standard therapy for advanced gastric and esophageal adenocarcinomas, incl…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study of Sigvotatug Vedotin in Advanced Solid Tumors [Phase 1]
Phase 1 study of Sigvotatug Vedotin in advanced solid tumors is currently recruiting. The trial targets multiple indications, including non-…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors [Phase 1]
Phase 1 study evaluating SGN-CEACAM5C in adults with advanced solid tumors is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Safety and Efficacy of CT0494BCP in Participants With Advanced Gastric/Esophagogastric Junction Adenocarcinoma
A clinical trial update describes the planned safety and efficacy assessment of CT0494BCP in adults with advanced gastric or gastroesophagea…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Preoperative Hypofractionated Radiotherapy With FOLFOX for Esophageal or Gastroesophageal Junction Adenocarcinoma [Phase 2]
A Phase 2 clinical trial evaluating preoperative hypofractionated radiotherapy in combination with the FOLFOX regimen for esophageal or gast…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: NBTXR3, Chemotherapy, and Radiation Therapy for the Treatment of Esophageal Cancer [Phase 1]
Phase 1 trial evaluating NBTXR3 in combination with chemotherapy and radiation therapy for esophageal cancer; recruitment is ongoing across …
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FDA approval · 2026-04-15FDA Approved: ONTRUZANT — Supplemental Application (Organon LLC)
FDA approved a supplemental application for ONTRUZANT (trastuzumab) submitted by Organon LLC. The approval encompasses labeling updates rela…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Paclitaxel for the Treatment of Gastric or Gastroesophageal Cancer [Phase 1]
Phase 1 study evaluating paclitaxel for gastric cancer and gastroesophageal junction adenocarcinoma; the trial includes metastatic/stage IV …
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Study of ASP546C in Adults With Gastroesophageal Cancer, Pancreatic Cancer or Other Solid Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating ASP546C in adults with gastric/GEJ adenocarcinoma, pancreatic adenocarcinoma, or other solid tumors is…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread [Phase 1, Phase 2]
A Phase 1/2 trial evaluating the dose of Zongertinib used alone or with other therapies in HER2-positive metastatic cancers, including breas…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Nivolumab, Ipilimumab and Chemoradiation in Treating Patients With Resectable Gastric Cancer [Phase 2]
A Phase 2 clinical trial evaluating nivolumab and ipilimumab in combination with chemoradiation for resectable gastric cancer and gastroesop…
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: Phase 1/2 Study of BHB810 in Advanced Gastric and GEJ Adenocarcinoma [Phase 1, Phase 2]
Clinical trial update indicates a Phase 1/2 study of BHB810 in advanced gastric and GEJ adenocarcinoma, with the trial currently not yet rec…
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CLINICAL_TRIALS trial_result · 2026-04-14Clinical Trial Update: Trastuzumab Deruxtecan Plus Nivolumab Plus Capecitabine Plus Oxaliplatin for HER2 Low Gastric and Gastroesophageal Junction Adenocarcinoma [Phase 1, Phase 2]
A Phase 1/2 trial evaluating trastuzumab deruxtecan in combination with nivolumab, capecitabine, and oxaliplatin for HER2-low gastric and ga…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: A Phase Ib/II Study of ATG-022 Plus Pembrolizumab With/Without Chemotherapy in Participants With Claudin (CLDN) 18.2-positive, HER2-negative, Unresectable or Metastatic Gastric or Gastroesophageal Junction AdenocarcinomaUnresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma [Phase 1, Phase 2]
A Phase Ib/II clinical trial evaluating ATG-022 in combination with pembrolizumab, with or without chemotherapy, for CLDN18.2-positive, HER2…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2 [Phase 3]
Phase 3 trial evaluating Sonesitatug Vedotin with Capecitabine, with or without Rilvegostomig, in advanced or metastatic Claudin18.2-express…
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CLINICAL_TRIALS label_change · 2026-04-13Clinical Trial Update: Testing the Combination of the Anticancer Drugs Trastuzumab Deruxtecan (DS-8201a) and Azenosertib (ZN-c3) in Patients With Stomach or Other Solid Tumors [Phase 1]
Phase 1 clinical trial evaluating the combination of trastuzumab deruxtecan (DS-8201a) and azenosertib (ZN-c3) in gastric and gastroesophage…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors [Phase 1]
Plexium, Inc. is conducting a first-in-human Phase 1 study of PLX-61639 in locally advanced or metastatic solid tumors, and the trial is cur…