Gastroesophageal Junction Adenocarcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: A Single-arm, Multicenter Exploratory Clinical Trial of Anlotinib Combined With TQB2450 and the SOX Regimen as First-line Treatment for Advanced Gastric Cancer With Low PD-L1 Expression [Phase 2]
A Phase 2, single-arm exploratory trial evaluating a triple combination of anlotinib, TQB2450, and the SOX chemotherapy regimen as first-lin…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma [Phase 3]
A Phase 3 trial is evaluating mFOLFIRINOX versus mFOLFOX with or without nivolumab for HER2-negative advanced, unresectable, or metastatic e…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors [Phase 1]
Pfizer's Phase 1 study PF-08046876 is recruiting adults with various advanced solid tumors to evaluate safety and dosing. The trial includes…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer [Phase 3]
A Phase 3 clinical trial comparing proton therapy to photon radiation therapy for esophageal cancer across multiple stages and histologies i…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Observational Study of Patients Treated With Nivolumab and Chemotherapy for Advanced or Metastatic Esophageal, Gastroesophageal or Gastric Cancer in France
An observational study in France evaluating outcomes for patients with advanced gastric and esophageal cancers treated with nivolumab in com…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer [Phase 3]
This entry reports a Phase 3 clinical trial evaluating zolbetuximab in combination with pembrolizumab and chemotherapy for gastric cancer an…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Dynamic ctDNA-Guided Adjuvant Therapy in cStage III and IVA Gastric or Gastroesophageal Junction Adenocarcinoma [Phase 2]
Phase 2 trial evaluating dynamic ctDNA-guided adjuvant therapy for stage III and IV gastric or gastroesophageal junction adenocarcinoma; cur…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma [Phase 2]
Phase 2 clinical trial evaluating the adverse events, efficacy, and optimal dose of ABBV-400 in combination with fluorouracil, leucovorin, a…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: A Clinical Study of Iparomlimab and Tuvonralimab Combined With SOX Following Heterogeneous Radiotherapy as First-line Treatment for Unresectable Locally Advanced or Metastatic HER2-negative Gastric or Gastroesophageal Junction Adenocarcinoma [Phase 4]
Phase 4 clinical trial evaluating iparomlimab and tuvonralimab with SOX chemotherapy as first-line treatment for unresectable HER2-negative …
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: A Clinical Study of Sintilimab Combined With Chemothrapy Versus Chemotherapy as Adjuvant Therapy for Gastric/Gastroesophageal Junction Adenocarcinoma [Phase 2]
A Phase 2 clinical trial in China evaluating sintilimab plus chemotherapy versus chemotherapy alone as adjuvant therapy for gastric or gastr…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: A Real-World, Single-Arm Study Protocol of Disitamab Vedotin in Combination With Immunotherapy and Multimodal Radiation Therapy for HER2-Positive Advanced Gastric Cancer: After Second-Line Treatment Failure
This document outlines a real-world, single-arm study protocol evaluating disitamab vedotin in combination with immunotherapy and multimodal…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: A Phase 1/1b of RNDO-564 Single Agent or in Combination With Pembrolizumab in Bladder Cancer and Other Solid Tumors Associated With Nectin-4 [Phase 1]
Phase 1/1b trial evaluating RNDO-564 as a single agent or in combination with pembrolizumab in bladder cancer and nectin-4–associated solid …
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity [Phase 2, Phase 3]
A Phase 2/3 clinical trial is evaluating the addition of Paclitaxel administered intraperitoneally with standard chemotherapy for gastric ca…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Phase II Trial of Neoadjuvant Thymalfasin, PD-1 Inhibitor, and Chemoradiotherapy for cStage III GEJ Adenocarcinoma [Phase 2]
This Clinical Trials update notes a Phase II neoadjuvant trial combining thymosin alpha-1, a PD-1 inhibitor, and chemoradiotherapy for stage…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: IBI343 in Combination Therapy for Advanced Malignant Solid Tumors [Phase 2]
This is a Phase 2 clinical trial update for IBI343 in combination therapy targeting CLDN18.2-positive advanced solid tumors, including gastr…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Sonidegib and Pembrolizumab in Treating Patients With Advanced Solid Tumors [Phase 1]
This update reports on a Phase 1 trial testing the combination of sonidegib and pembrolizumab in patients with various advanced solid tumors…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Novel Combinations in Participants With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma [Phase 2]
A Phase 2 trial from AstraZeneca is evaluating novel drug combinations in participants with locally advanced unresectable or metastatic gast…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: AVA6103 in Subjects With Locally Advanced or Metastatic Selected Solid Tumors [Phase 1]
Phase 1 clinical trial update for AVA6103 in patients with locally advanced or metastatic selected solid tumors; the study is currently recr…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Safety and Pharmacokinetics of Tucatinib (MK-7119) in Chinese Participants With Cancer (MK-7119-002) [Phase 1]
Phase 1 clinical trial MK-7119-002 assesses safety and pharmacokinetics of tucatinib (MK-7119) in Chinese participants with cancer; the stud…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors [Phase 1, Phase 2]
A Mayo Clinic-sponsored phase 1/2 trial evaluating a personalized neoantigen peptide-based vaccine in combination with pembrolizumab for adv…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: HS-20093 in Patients With Advanced Gastric and Gastroesophageal Junction Adenocarcinoma [Phase 1]
This document notes an ongoing Phase 1 trial of HS-20093 for advanced gastric and gastroesophageal junction adenocarcinoma, with recruitment…
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CLINICAL_TRIALS research · 2026-03-06Clinical Trial Update: A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurrence and the Effect of Risk Profile Disclosure on Patient Quality of Life and Fear of Cancer [NA]
This clinical trial aims to optimize a risk model to predict cancer recurrence in Barrett's esophagus patients and to study the impact of ri…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer [Phase 1]
A Phase 1 clinical trial evaluating the combination of Lonsurf (trifluridine/tipiracil) and Talzenna (talazoparib) for locally advanced or m…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Real-WorlD ZolbetUximab in Patients With HER-2 Negative and CLaudin 18.2 PosItive MetastatiC AdEnocarcinoma
This clinical trial update describes a real-world study of zolbetuximab in patients with HER-2 negative, Claudin-18.2–positive metastatic ga…
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: Bemarituzumab or Placebo Plus Chemotherapy in Gastric Cancers With Fibroblast Growth Factor Receptor 2b (FGFR2b) Overexpression [Phase 3]
Phase 3 trial evaluating bemarituzumab plus chemotherapy versus placebo plus chemotherapy in FGFR2b-overexpressing gastric and gastroesophag…